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| Product Type | Recombinant Protein |
| Uniprot No. | P38438 |
| Species | Rattus norvegicus (Rat) |
| Gene Names | Tgfbr2 |
| Protein Names | Recommended name: TGF-beta receptor type-2 Short name= TGFR-2 EC= 2.7.11.30Alternative name(s): TGF-beta type II receptor Transforming growth factor-beta receptor type II Short name= TGF-beta receptor type II Short na |
| Storage | Store at -20°C, for extended storage, conserve at -20°C or -80°C. |
| Notes | Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week. |
| Target Details | This gene encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. |
| HGNC | 11773 |
| RGD | 69651 |
| MGI | 98729 |
| Function | Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways (By similarity). |
| Subcellular Location | Cell membrane, Single-pass type I membrane protein, Membrane raft |
| Protein Families | Protein kinase superfamily, TKL Ser/Thr protein kinase family, TGFB receptor subfamily |
| Database Links |
KEGG: rno:81810 STRING: 10116.ENSRNOP00000035501 UniGene: Rn.164421 |
| Pathway |
Hippo signaling pathway
MAPK signaling pathway TGF-beta signaling pathway Adherens junction Cellular senescence Osteoclast differentiation Th17 cell differentiation AGE-RAGE signaling pathway in diabetic complications FoxO signaling pathway Endocytosis |
| Product Name | Recombinant Rat TGF-beta receptor type-2(Tgfbr2),partial,Yeast |
| Code | CSB-YP023452RA1 |
| Size | Pls inquiry other sizes |
| Source | Yeast |
| Purity | >85% (SDS-PAGE) |
| Tag Info | The following tags are available. N-terminal His-tagged Tag-Free The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
|
| Sequence | IPPHVPK SVNSDLMAGD NSGAVKLPQL CKFCDVTLST CDNQKSCMSN CSVTSICEKP QEVCVAVWRK NDKNITLETV CHDPKFTYHG FTLEDATSPT CVMKEKKRAG ETFFMCSCNT EECNDYIIFN EEYTTSSPDL LLVIIQ |
| Expression Region | 24-166 |
| Protein Description | Partial |
| Storage Buffer | Tris-based buffer,50% glycerol |
| Still Have Questions? | Leave a Message or Start an on-line Chat |
| Product Name | Recombinant Rat TGF-beta receptor type-2(Tgfbr2),partial,Mammalian cell |
| Code | CSB-MP023452RA1 |
| Size | Pls inquiry other sizes |
| Source | Mammalian cell |
| Purity | >85% (SDS-PAGE) |
| Tag Info | The following tags are available. N-terminal His-tagged and C-terminal Myc-tagged N-terminal His-tagged Tag-Free The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
|
| Sequence | IPPHVPK SVNSDLMAGD NSGAVKLPQL CKFCDVTLST CDNQKSCMSN CSVTSICEKP QEVCVAVWRK NDKNITLETV CHDPKFTYHG FTLEDATSPT CVMKEKKRAG ETFFMCSCNT EECNDYIIFN EEYTTSSPDL LLVIIQ |
| Expression Region | 24-166 |
| Protein Description | Partial |
| Storage Buffer | Tris-based buffer,50% glycerol |
| Still Have Questions? | Leave a Message or Start an on-line Chat |
Tgfbr2 Antibodies for Rattus norvegicus (Rat)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA023452ZA01RA | Tgfbr2 Antibody | Rattus norvegicus | ELISA, WB (ensure identification of antigen) |
Tgfbr2 Proteins for Rattus norvegicus (Rat)
| Code | Product Name | Source |
|---|---|---|
| CSB-EP023452RA1 | Recombinant Rat TGF-beta receptor type-2(Tgfbr2),partial | E.coli |
| CSB-CF023452RA | Recombinant Rat TGF-beta receptor type-2(Tgfbr2) | in vitro E.coli expression system |
| CSB-BP023452RA1 | Recombinant Rat TGF-beta receptor type-2(Tgfbr2), partial | Baculovirus |
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