Recombinant Rat TGF-beta receptor type-2 (Tgfbr2), partial

1. Findings outlined in the current study demonstrated that 1,25(OH)2D3 was a promising therapeutic modality for treatment of Pulmonary arterial hypertension, function of which was exerted through miR-204 mediated Tgfbr2 signaling. PMID: 29196166
2. Blocking Hsp90-Cdc37 interactions during pressure overload hypertrophy results in ubiquitin-mediated proteasomal degradation of TGFBR2 leading to termination of TGF beta mediated signaling. PMID: 26362850
3. The levels of collagen I and alpha-SMA were downregulated in CS/S58 gel-treated eyes. Conjunctival fibroblast proliferation and the inflammation response were also suppressed in the CS/S58 gel-treated group. PMID: 26284552
4. Morphological and biochemical data about the endosomal compartments involved in the internalization of TbetaRII upon inflammatory stimuli are shown. PMID: 25813266
5. We proved that miRNA-337 is associated with chondrogenesis through regulating TGFBR2 expression, and miRNA-337 can also influence cartilage-specific gene expression in chondrocytes. PMID: 22425884
6. the increased dimerization of TbetaRII in hypertrophic cardiomyocytes comparing to the normal cardiomyocytes was found. PMID: 21382347
7. These data indicated that knockdown of TGFbetaRII expression inhibited the activation of hepatic stellate cells and the production of fibrogenic extracellular matrix components in HSC-T6 cells. PMID: 21378033
8. Dragon's Blood can effectively reduce pulmonary fibrosis by inhibiting the expression of TGFbetaR II mRNA in the lung tissue. PMID: 17953362
9. Differential expression of TGF-beta type I and II receptors by pulmonary cells in bleomycin-induced lung injury correlate with repair and fibrosis, with reduced Tgfbr2 expression occurring during the later (days 14-28 )decreased cell proliferation stage. PMID: 11936776
10. TGFBRII expression is induced by acetaldehyde, a major active metabolite of alcohol PMID: 12223100
11. Tgfbr2 had a marked yet transient upregulation in glomerular cells in experimental glomerulonephritis. PMID: 12545247
12. detection of TGFbetas, TbetaRII expression and telomerase activity in hyperplastic, dysplastic cholangiocytes, cholangiocarcinoma cells as well as in stroma fibroblasts during cholangiocarcinogenesis PMID: 12632524
13. albumin-induced internalization of TbetaRII signaling may be an important mechanism in the vessel wall for controlling TGF-beta responses in endothelial cells PMID: 14729511
14. The decreased expression of TGF-beta1 mRNA in the hypoplastic heart suggests that the downregulation of RAS may be involved in the pathogenesis of cardiac hypoplasia in nitrofen-induced CDH. PMID: 15578192
15. Maximal content of TGFbetaRII has been observed immunohistochemically in the early stage of pancreatic regeneration following ischemia/reperfusion-induced acute pancreatitis, suggesting the involvement of this growth factor in pancreatic recovery. PMID: 15613744
16. Pituitary cells, which demonstrate reduced expression of dopamine beta2 receptor, also show reduction of TGFbeta1 type II receptor. PMID: 15961557
17. Connective tissue growth factor, which is induced by TGFbeta, is expressed only iin heart transplantations with chronic rejection. PMID: 16611331
18. Transforming growth factor beta receptor 2 were obviously expressed in primitive pulmonary alveolus, showing it plays an important regulatory role in the development of rat embryo and embryonic lung, especially in organic morphodifferentiation. PMID: 17428384
19. transforming growth factor-beta receptor II promoter is methylated by lentivirus-mediated shRNA delivery PMID: 17533113
20. Tgfbr2 was methylated and markedly down-regulated in three of seven 3,2'-dimethyl-4-aminobiphenyl-induced invasive adenocarcinomas in the dorsolateral lobe of the rat prostate. PMID: 18381416

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KEGG: rno:81810

STRING: 10116.ENSRNOP00000035501

UniGene: Rn.164421