Recombinant Saccharomyces cerevisiae Serine/threonine-protein kinase TEL1 (TEL1), partial

1. Our findings provide a model in which two different Tel2 pathways promote protein stabilization of Mec1 and Tel1 in budding yeast. PMID: 28827813
2. In this study, we characterized functions of the FATC domain of Tel1 by introducing substitution or truncation mutations. PMID: 26246601
3. once loaded to a double-strand break (DSB) by the MRX complex, promotes/stabilizes MRX association to the DSB in a positive feedback loop PMID: 26901759
4. By performing a genetic screen, we identify rad53 and tel1 mutant alleles that suppress both the DNA damage hypersensitivity and the resection defect of sae2Delta cells through an Sgs1-Dna2-dependent mechanism PMID: 26584331
5. In the absence of Tel1, a significant proportion of crossovers occur through a non-ZMM-dependent pathway, contributing to a crossover landscape with poor interference. PMID: 26305689
6. Tel1 directs early replication and phosphorylates Rif1.Tel1 acts upstream of Rif1 in controlling telomere replication timing. PMID: 25329891
7. Tel1 plays role in signal transduction during DNA replication. PMID: 25752575
8. These results establish that Tel1(ATM) specifies not only the extent but also the timing of telomerase recruitment PMID: 25122631
9. observations support a hierarchical view of recombination initiation where Tel1(ATM) prevents clusters of DNA double-strand breaks, and further suppresses DSBs within the surrounding chromosomal region PMID: 25539084
10. Retaining a chrV L telomeric hph marker was significantly higher in tel1Delta, sae2Delta. PMID: 24699249
11. Pch2 prevents Mec1/Tel1-mediated Hop1 phosphorylation occurring independently of Red1 in Saccharomyces cerevisiae meiosis. PMID: 24465650
12. We show here that Tel1p and Rad53p, homologs of the mammalian DNA damage response kinases ATM and Chk2, mediate a hormetic mtROS longevity signal that extends yeast chronological lifespan. PMID: 23747251
13. Tel1 is critical for DNA damage response and telomere homeostasis. PMID: 23378069
14. Red1-SUMO-C interaction mediates both Mec1- and Tel1-mediated Hop1-T318 phosphorylation. PMID: 23775120
15. The results show that Tel1 and Rad51 have multiple roles in the maintenance of vertebrate-like telomeres in yeast, supporting the idea that they may participate to evolutionary conserved telomere protection mechanisms acting at uncapped telomeres. PMID: 23677619
16. Tel1 and Mec1, the budding yeast ATM and ATR, respectively, down-regulate Rec114 upon meiotic DSB formation through phosphorylation PMID: 23825959
17. MRN/MRX recognizes double-strand break ends and recruits Tel1 to the DNA ends. Protein attachment at DNA ends enhances Tel1 activation through MRX function, whereas protein tethering in the middle of DNA fragments does not. PMID: 21402778
18. Chromosome rearrangements and aneuploidy in yeast strains lacking both Tel1p and Mec1p reflect deficiencies in two different mechanisms PMID: 20534547
19. Tel1 mutations are associated with increased rates of spontaneous loss of heterozygosity leading to genome instability. PMID: 20410660
20. CDK1 complexes participate in triggering the Tel1-dependent checkpoint and are required to maintain both Mec1- and Tel1-dependent Rad53 phosphorylation, which are critical events in the DNA damage checkpoint cascade PMID: 15542824
21. We present the characterization of a new mutation in the TEL1-gene, called tel1-11. Telomere and checkpoint functions are differentially affected by the mutant protein Tel1-11p. PMID: 16228207
22. The viability of yku70Delta mec1Delta and yku80Delta mec1Delta cells depends on the ATM-related Tel1 kinase, the Mre11-Rad50-Xrs2 complex, and the DNA damage checkpoint protein Rad9 PMID: 16287875
23. Sae2 phosphorylation depends on the checkpoint kinases Mec1 and Tel1, whose simultaneous deletion also impairs meiotic DNA double-strand break repair PMID: 16861895
24. beta-lapachone activates a Mre11p-Tel1p checkpoint pathway in budding yeast PMID: 17106258
25. These data argue that Mre11p and Tel1p affect telomere length by promoting telomerase recruitment to telomeres, whereas Mec1p has only a minor role in telomerase recruitment in a TEL1 cell. PMID: 17188035
26. Tel1, the ATM orthologue, has two functions in checkpoint response to double-strand breaks. PMID: 17347674
27. Sae2 and Tel1 promote microhomology-mediated end joining but inhibit non-homologous end joining, likely by regulating Mre11-dependent ssDNA accumulation at DNA break. PMID: 17565964
28. These data suggest that Tel1p targets telomerase to the DNA ends most in need of extension. PMID: 17656141
29. A chromatin remodeling complex is established as a functional component in the Mec1/Tel1 DNA damage signaling pathway that modulates checkpoint responses. PMID: 17693258
30. Tel1p preferentially associates with the shortest telomeres and stimulates their elongation by telomerase. PMID: 17803948
31. Telomerase repeat addition processivity is significantly increased at extremely short telomeres, a process that is dependent on the ATM-ortholog Tel1. PMID: 17908934
32. Data show that Tel1 kinase and subtelomere-bound Tbf1 mediate preferential elongation of short telomeres by telomerase in yeast. PMID: 17917674
33. Tel1-hy544 can activate the checkpoint more efficiently than wild-type Tel1 PMID: 17954565
34. Study demonstrates that Mec1 and Tel1 promote meiotic interhomolog recombination by targeting the axial element protein Hop1. PMID: 18329363
35. Data show that Tel1 and Tel2 interact, and that even when Tel1 protein levels are high, this interaction is specifically required for Tel1 localization to a DNA break and its activation of downstream targets. PMID: 18334620
36. Mec1 and Tel1 inhibit anaphase in response to DNA damage by utilizing spindle assembly checkpoint proteins. PMID: 18454191
37. Results define a conserved sequence motif within an otherwise poorly defined region of the Tel1/ATM kinase family proteins that is essential for normal Tel1 function in Saccharomyces cerevisiae. PMID: 18625723
38. like human ATM, Tel1 serves as a key regulator for chromosome integrity in the pathway that reduces the risk for DSB-induced chromosome translocations, and are probably pertinent to the oncogenic chromosome translocations in ATM-deficient cells PMID: 18650924
39. Budding yeasts carrying human-type telomeric repeats at their chromosome termini show a chronic activation of the Rad53-dependent DNA damage checkpoint pathway and a G2/M cell cycle delay. PMID: 19007917
40. Tel1p has two separate functions in telomere maintenance and that the Xrs2p-dependent recruitment of Tel1p to telomeres plays an important role even in the absence of its kinase activity. PMID: 19596790

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KEGG: sce:YBL088C

STRING: 4932.YBL088C