Recombinant Sheep 14-3-3 protein beta/alpha(YWHAB)

Product Type Recombinant Protein
Uniprot No. P68251
Species Ovis aries (Sheep)
Gene Names YWHAB
Protein Names Recommended name: 14-3-3 protein beta/alpha Alternative name(s): Protein kinase C inhibitor protein 1 Short name= KCIP-1 Cleaved into the following chain: 1. 14-3-3 protein beta/alpha, N-terminally processed
Storage Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Target Details This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene.
HGNC 12849
RGD 61998
MGI 1891917
Function Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13.
Subcellular Location Cytoplasm, Melanosome
Protein Families 14-3-3 family
Database Links

UniGene: Oar.14354

Pathway Hippo signaling pathway
PI3K-Akt signaling pathway
Cell cycle

Product Details for Different Expression Systems

Product Name Recombinant Sheep 14-3-3 protein beta/alpha(YWHAB),Yeast
Code CSB-YP026285SH
Size Pls inquiry other sizes
Source Yeast
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence MTMDKSELVQ KAKLAEQAER YDDMAAAMKA VTEQGHELSN EERNLLSVAY KNVVGARRSS WRVISSIEQK TERNEKKQQM GKEYKMKGDY FRYLSEVASG DNKQTTVSNS QQAYQEAFEI SKKEMQPTHP IRLGLALNFS VFYYEILNSP EAIAELDTLN EESYKDSTLI MQLLRDNLTL WTSENQGDEG DAG
Expression Region 1-193
Protein Description Full length protein
Storage Buffer Tris-based buffer,50% glycerol
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Product Name Recombinant Sheep 14-3-3 protein beta/alpha(YWHAB),E.coli
Code CSB-EP026285SH
Size Pls inquiry other sizes
Source E.coli
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-SUMO-tagged and C-terminal Myc-tagged
N-terminal His-B2M-tagged and C-terminal Myc-tagged
N-terminal His-GST-tagged and C-terminal Myc-tagged
N-terminal His-tagged
N-terminal His-SUMO-tagged
N-terminal His-B2M-tagged
N-terminal His-GST-tagged
N-terminal GST-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence MTMDKSELVQ KAKLAEQAER YDDMAAAMKA VTEQGHELSN EERNLLSVAY KNVVGARRSS WRVISSIEQK TERNEKKQQM GKEYKMKGDY FRYLSEVASG DNKQTTVSNS QQAYQEAFEI SKKEMQPTHP IRLGLALNFS VFYYEILNSP EAIAELDTLN EESYKDSTLI MQLLRDNLTL WTSENQGDEG DAG
Expression Region 1-193
Protein Description Full length protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Sheep 14-3-3 protein beta/alpha(YWHAB),Baculovirus
Code CSB-BP026285SH
Size Pls inquiry other sizes
Source Baculovirus
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence MTMDKSELVQ KAKLAEQAER YDDMAAAMKA VTEQGHELSN EERNLLSVAY KNVVGARRSS WRVISSIEQK TERNEKKQQM GKEYKMKGDY FRYLSEVASG DNKQTTVSNS QQAYQEAFEI SKKEMQPTHP IRLGLALNFS VFYYEILNSP EAIAELDTLN EESYKDSTLI MQLLRDNLTL WTSENQGDEG DAG
Expression Region 1-193
Protein Description Full length protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Sheep 14-3-3 protein beta/alpha(YWHAB),Mammalian cell
Code CSB-MP026285SH
Size Pls inquiry other sizes
Source Mammalian cell
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence MTMDKSELVQ KAKLAEQAER YDDMAAAMKA VTEQGHELSN EERNLLSVAY KNVVGARRSS WRVISSIEQK TERNEKKQQM GKEYKMKGDY FRYLSEVASG DNKQTTVSNS QQAYQEAFEI SKKEMQPTHP IRLGLALNFS VFYYEILNSP EAIAELDTLN EESYKDSTLI MQLLRDNLTL WTSENQGDEG DAG
Expression Region 1-193
Protein Description Full length protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat

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