Recombinant Staphylococcus aureus Iron-regulated surface determinant protein A(isdA)

Product Type Recombinant Protein
Uniprot No. Q6GHV6
Abbreviation isdA
Species Staphylococcus aureus (strain MRSA252)
Gene Names isdA
Protein Names Recommended name: Iron-regulated surface determinant protein A Alternative name(s): Fur-regulated protein A Staphylococcal transferrin-binding protein A
Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Function Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activated holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible. Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B-beta and gamma of fibrinogen. Could play a role in the removal of heme from hemoglobin. The IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. May function as a reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and/or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity).
Subcellular Location Secreted, cell wall, Peptidoglycan-anchor
Database Links

KEGG: sar:SAR1103

Product Details for Different Expression Systems

Product Name Recombinant Staphylococcus aureus Iron-regulated surface determinant protein A(isdA),Yeast
Code CSB-YP743380SKV
Size Pls inquiry other sizes
Source Yeast
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence ATEA TNATNNQSTQ VSQATSQPIN FQVQKDGSSE KSHMDDYMQH PGKVIKQNNK YYFQAVLNNA SFWKEYKFYN ANNQELATTV VNDDKKADTR TINVAVEPGY KSLTTKVHIV VPQINYNHRY TTHLEFEKAI PTLADAAKPN NVKPVQPKPA QPKTPTEQTK PVQPKVEKVK PAVTAPSKNE NRQTTKVVSS EATKDQSQTQ SARTVKTTQT AQDQNKVQTP VKDVATAKSE SNNQAVSDNK SQQTNKVTKQ NEVHKQGPSK DSKAKELPKT
Expression Region 47-320
Protein Description Full Length of Mature Protein
Storage Buffer Tris-based buffer,50% glycerol
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Product Name Recombinant Staphylococcus aureus Iron-regulated surface determinant protein A(isdA),E.coli
Code CSB-EP743380SKV
Size Pls inquiry other sizes
Source E.coli
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-SUMO-tagged and C-terminal Myc-tagged
N-terminal His-B2M-tagged and C-terminal Myc-tagged
N-terminal His-GST-tagged and C-terminal Myc-tagged
N-terminal His-tagged
N-terminal His-SUMO-tagged
N-terminal His-B2M-tagged
N-terminal His-GST-tagged
N-terminal GST-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence ATEA TNATNNQSTQ VSQATSQPIN FQVQKDGSSE KSHMDDYMQH PGKVIKQNNK YYFQAVLNNA SFWKEYKFYN ANNQELATTV VNDDKKADTR TINVAVEPGY KSLTTKVHIV VPQINYNHRY TTHLEFEKAI PTLADAAKPN NVKPVQPKPA QPKTPTEQTK PVQPKVEKVK PAVTAPSKNE NRQTTKVVSS EATKDQSQTQ SARTVKTTQT AQDQNKVQTP VKDVATAKSE SNNQAVSDNK SQQTNKVTKQ NEVHKQGPSK DSKAKELPKT
Expression Region 47-320
Protein Description Full Length of Mature Protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Staphylococcus aureus Iron-regulated surface determinant protein A(isdA),Baculovirus
Code CSB-BP743380SKV
Size Pls inquiry other sizes
Source Baculovirus
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence ATEA TNATNNQSTQ VSQATSQPIN FQVQKDGSSE KSHMDDYMQH PGKVIKQNNK YYFQAVLNNA SFWKEYKFYN ANNQELATTV VNDDKKADTR TINVAVEPGY KSLTTKVHIV VPQINYNHRY TTHLEFEKAI PTLADAAKPN NVKPVQPKPA QPKTPTEQTK PVQPKVEKVK PAVTAPSKNE NRQTTKVVSS EATKDQSQTQ SARTVKTTQT AQDQNKVQTP VKDVATAKSE SNNQAVSDNK SQQTNKVTKQ NEVHKQGPSK DSKAKELPKT
Expression Region 47-320
Protein Description Full Length of Mature Protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Staphylococcus aureus Iron-regulated surface determinant protein A(isdA),Mammalian cell
Code CSB-MP743380SKV
Size Pls inquiry other sizes
Source Mammalian cell
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence ATEA TNATNNQSTQ VSQATSQPIN FQVQKDGSSE KSHMDDYMQH PGKVIKQNNK YYFQAVLNNA SFWKEYKFYN ANNQELATTV VNDDKKADTR TINVAVEPGY KSLTTKVHIV VPQINYNHRY TTHLEFEKAI PTLADAAKPN NVKPVQPKPA QPKTPTEQTK PVQPKVEKVK PAVTAPSKNE NRQTTKVVSS EATKDQSQTQ SARTVKTTQT AQDQNKVQTP VKDVATAKSE SNNQAVSDNK SQQTNKVTKQ NEVHKQGPSK DSKAKELPKT
Expression Region 47-320
Protein Description Full Length of Mature Protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat

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