Recombinant Xenopus laevis Cellular tumor antigen p53 (tp53)

Code CSB-YP024077XBE
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Source Yeast
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Code CSB-EP024077XBE
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Source E.coli
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Code CSB-EP024077XBE-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP024077XBE
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Source Baculovirus
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Code CSB-MP024077XBE
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
tp53
Uniprot No.
Alternative Names
tp53; Cellular tumor antigen p53; Tumor suppressor p53
Species
Xenopus laevis (African clawed frog)
Expression Region
1-363
Target Protein Sequence
MEPSSETGMD PPLSQETFED LWSLLPDPLQ TVTCRLDNLS EFPDYPLAAD MTVLQEGLMG NAVPTVTSCA VPSTDDYAGK YGLQLDFQQN GTAKSVTCTY SPELNKLFCQ LAKTCPLLVR VESPPPRGSI LRATAVYKKS EHVAEVVKRC PHHERSVEPG EDAAPPSHLM RVEGNLQAYY MEDVNSGRHS VCVPYEGPQV GTECTTVLYN YMCNSSCMGG MNRRPILTII TLETPQGLLL GRRCFEVRVC ACPGRDRRTE EDNYTKKRGL KPSGKRELAH PPSSEPPLPK KRLVVVDDDE EIFTLRIKGR SRYEMIKKLN DALELQESLD QQKVTIKCRK CRDEIKPKKG KKLLVKDEQP DSE
Protein Length
full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.
Gene References into Functions
  1. Furthermore, while activities to process procaspase-8 and procaspase-9 appeared in SAMDC-overexpressed apoptotic embryos, the activity to process procaspase-8 did not appear in p53-overexpressed apoptotic embryos. [SAMDC] PMID: 16143307
Subcellular Location
Cytoplasm. Nucleus.
Protein Families
P53 family
Tissue Specificity
Ubiquitous.
Database Links

KEGG: xla:397926

UniGene: Xl.394

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