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Recombinant Xenopus laevis Stromal cell-derived factor 1 (cxcl12)

Recombinant Xenopus laevis Stromal cell-derived factor 1 (cxcl12)

Code	CSB-YP844964XBE
MSDS	MSDS
Size	Pls inquire
Source	Yeast
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Code	CSB-EP844964XBE
MSDS	MSDS
Size	Pls inquire
Source	E.coli
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Code	CSB-EP844964XBE-B
MSDS	MSDS
Size	Pls inquire
Source	E.coli
Conjugate	Avi-tag Biotinylated E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code	CSB-BP844964XBE
MSDS	MSDS
Size	Pls inquire
Source	Baculovirus
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Code	CSB-MP844964XBE
MSDS	MSDS
Size	Pls inquire
Source	Mammalian cell
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Product Details
Customer Reviews and Q&A
Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

cxcl12

Uniprot No.

Q8UUJ9

Alternative Names

cxcl12; sdf1; Stromal cell-derived factor 1; xSDF-1; C-X-C motif chemokine 12

Species

Xenopus laevis (African clawed frog)

Expression Region

22-94

Target Protein Sequence

KPVSLVYRC PCRYFESNVP KSNIKHLKIL STSNCSLQIV ARLKHNGKQI CLDPKTKWIQ EYLEKALNKK AKKT

Protein Length

Full Length of Mature Protein

Tag Info

Tag type will be determined during the manufacturing process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Form

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer before Lyophilization

Tris/PBS-based buffer, 6% Trehalose, pH 8.0

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet

Please contact us to get it.

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Function

Chemoattractant. Activates the C-X-C chemokine receptor cxcr4 to induce a rapid and transient rise in the level of intracellular calcium ions, and chemotaxis. Signaling with cxcr4 mediates the directional movement of mesodermal cells during gastrulation (Ref.2). Binds to the allosteric site (site 2) of integrins and activates them in a cxcr4-independent manner.

Gene References into Functions

These findings support the conservation of sdf-1alpha signaling in vertebrate somite morphogenesis; however, the precise mechanism by which this signaling pathway influences somite morphogenesis is different between the fish and the frog. PMID: 24357195
SDF-1/CXCR4 chemokine signaling is involved in the migration and survival or in the differentiation of PGCs in Xenopus PMID: 19770040
A significant increase of stromal cell-derived factor-1alpha and CXCR4 was observed in protein extracts of idiopathic inflammatory myopathies in comparison with normal controls. PMID: 15019705
SDF-1 signaling is necessary for migrations of massive numbers of cells during gastrulation. PMID: 17239342

Subcellular Location

Secreted.

Protein Families

Intercrine alpha (chemokine CxC) family

Tissue Specificity

Isoform alpha is expressed throughout the inner deep cells of the blastocoel roof during gastrula stage embryos. Isoform beta is expressed in the developing central nervous system (CNS) of embryos; at stages 21-23, up-regulated in the anterior of the embr

Database Links

KEGG: xla:399030

UniGene: Xl.4813

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