Recombinant Xenopus laevis Pancreas transcription factor 1 subunit alpha (ptf1a)

Code CSB-YP684248XBE
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Source Yeast
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Code CSB-EP684248XBE
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Source E.coli
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Code CSB-EP684248XBE-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP684248XBE
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Source Baculovirus
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Code CSB-MP684248XBE
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
ptf1a
Uniprot No.
Alternative Names
ptf1a; Pancreas transcription factor 1 subunit alpha; Pancreas-specific transcription factor 1a; Transcription factor Ptf1a/p48
Species
Xenopus laevis (African clawed frog)
Expression Region
1-270
Target Protein Sequence
METVLEQLAG LESFPSPYFD EDDFFTDHSS RDALDADDFL EDDVDFLAGQ IQDYYRDSRV LHTDDDYCDA GNFSFSSSSS GGFPYECGDG GCDLSPGMKG GSLVMKRRRR LRSDAEMQQL RQAANVRERR RMQSINDAFE GLRSHIPTLP YEKRLSKVDT LRLAIGYINF LSEMVQSDLP LRNPNSDSGN QPKKVIICHR GTRSPSPSDP DYGLPPLAGH SLSWTDEKQL RDQNVVRTAK VWTPEDPRKL NKSPFSNIEN EPPLTLCLDM
Protein Length
full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Acts together with pdx1 to induce the pancreatic lineage within the endoderm. Plays a central role in directing the differentiation of retinal progenitors towards horizontal and amacrine fates.
Gene References into Functions
  1. Our results demonstrate that Prdm13, downstream of Ptf1a, acts as an important regulator of glycinergic amacrine subtype specification in the Xenopus retina. We also reveal that Prdm13 regulates ptf1a expression through a negative feedback loop. PMID: 28863786
  2. Xenopus Ptf1a is essential for the initial specification of both endocrine and exocrine cells during normal pancreas development. PMID: 17320068
  3. Ptf1a overexpression leads to an increased ratio of GABAergic subtypes among the whole amacrine and horizontal cell population, highlighting its instructive capacity to promote this specific subtype of inhibitory neurons PMID: 17910758
  4. analysis of the gene regulatory network activated by Ptf1a in early pancreas development;results revealed that Ptf1a regulates genes with a wide variety of functions, providing insight into the complexity of the regulatory network required for pancreas specification PMID: 22815262
Subcellular Location
Nucleus.
Database Links

KEGG: xla:100381084

UniGene: Xl.29862

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