Recombinant Aspergillus niger NADPH--cytochrome P450 reductase(cprA)

Code CSB-CF018378AVE
Product Type Transmembrane Protein
Size Pls inquiry other sizes
Uniprot No. A2QS05
Storage Buffer Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Species Aspergillus niger (strain CBS 513.88 / FGSC A1513)
Sequence MAQLDTLDLVVLAVLLVGSVAYFTKGTYWAVAKDPYASTGPAMNGAAKAGKTRNIIEKMEETGKNCVIFYGSQTGTAEDYASRLAKEGSQRFGLKTMVADLEEYDYENLDQFPEDKVAFFVLATYGEGEPTDNAVEFYQFFTGDDVAFESGASADEKPLSKLKYVAFGLGNNTYEHYNAMVRQVDAAFQKLGAQRIGSAGEGDDGAGTMEEDFLAWKEPMWAALSESMDLQEREAVYEPVFCVTENESLSPEDETVYLGEPTQSHLQGTPKGPYSAHNPFIAPIAESRELFTVKDRNCLHMEISIAGSNLSYQTGDHIAVWPTNAGAEVDRFLQVFGLEGKRDSVINIKGIDVTAKVPIPTPTTYDAAVRYYMEVCAPVSRQFVATLAAFAPDEESKAEIVRLGSDKDYFHEKVTNQCFNIAQALQSITSKPFSAVPFSLLIEGITKLQPRYYSISSSSLVQKDKISITAVVESVRLPGASHMVKGVTTNYLLALKQKQNGDPSPDPHGLTYSITGPRNKYDGIHVPVHVRHSNFKLPSDPSRPIIMVGPGTGVAPFRGFIQERAALAAKGEKVGPTVLFFGCRKSDEDFLYKDEWKTYQDQLGDNLKIITAFSREGPQKVYVQHRLREHSELVSDLLKQKATFYVCGDAANMAREVNLVLGQIIAAQRGLPAEKGEEMVKHMRSSGSYQEDVWS
Source in vitro E.coli expression system
Gene Names cprA
Protein Names Recommended name: NADPH--cytochrome P450 reductase Short name= CPR Short name= P450R EC= 1.6.2.4
Expression Region 1-695
Tag Info N-terminal 10xHis-tagged
Protein Description full length protein
Storage Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis.
Subcellular Location Endoplasmic reticulum membrane, Single-pass membrane protein, Cytoplasmic side, Mitochondrion outer membrane, Single-pass membrane protein, Cytoplasmic side, Cell membrane, Single-pass membrane protein, Cytoplasmic side
Protein Families NADPH--cytochrome P450 reductase family; Flavodoxin family; Flavoprotein pyridine nucleotide cytochrome reductase family
Database Links

KEGG: ang:ANI_1_1104074

STRING: 5061.CADANGAP00006979

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