Recombinant Dog Triadin(TRDN)

Code CSB-CF024398DO
Product Type Transmembrane Protein
Size Pls inquiry other sizes
Uniprot No. P82179
Storage Buffer Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Species Canis lupus familiaris (Dog) (Canis familiaris)
Sequence MTEITAEGNASTTTTVIDSKNGSVPKSPGKVLKRTVTEDIVTTFSSPAAWLLVIALIITWSAVAVVMFDLVDYKNFSASSLSKIGSDPLKLVHDAVEETTDWVYGFFSLLSDIISSDGDEDDDDGDEDTDKGEIEEPPLKQKEIHKEKAEKEEKPERKILAKVAHREKEKVKEKEKSEKKATHKEKIEKKEKPETKTMAKEERKAKTEEKIKKEVKGGKQEKVKPTAAKVKEVQKTPPKAKEKEGKETAAVAKHEQKDQYAFCRYMIDMFVHGDLRPGQSPALPPPLPTVQASRPTPASPTLEGKEEEEKKKAEKKVTSETKKKEKEDVKKKSDKDTAIDVEKKEPGKAPETKQGTIKVVAQAAAKKDEKKEDSKKTKTPVEEHPKGKKQEKKEKYVEPAKSSKKEHSAPSEKQVKAKTERAKEETSAASTKKAVPGKKEEKTTKTVEQEIRKEKSGKTSTASKDKEPEIKKDEKMPKADKEVKPKPPQSQVKKEEKSESQVKKEAKPEQDIAKPEKTVSHGKPEEKVVKQVKATEKAAIEKTVKPKPAKKAEHQEKESPTIKTDKPKPTSKETPEVTESGKKKIEKSEKESKEKAEMKHLKEEKVSTRKESLQSHNVTKAEKPARVSREDLEDVSASKKAKEEAEDVSSTKRQKSPISFFQCVYLDGYNGYGFQFPVTPAYRPGESSGQPSSPGQKQQGQ
Source in vitro E.coli expression system
Gene Names TRDN
Protein Names Recommended name: Triadin
Expression Region 1-701
Tag Info N-terminal 10xHis-tagged
Protein Description full length protein
Storage Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Contributes to the regulation of lumenal Ca2+ release via the sarcoplasmic reticulum calcium release channels RYR1 and RYR2, a key step in triggering skeletal and heart muscle contraction. Required for normal organization of the triad junction, where T-tubules and the sarcoplasmic reticulum terminal cisternae are in close contact. Required for normal skeletal muscle strength. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats.
Subcellular Location Sarcoplasmic reticulum membrane, Single-pass type II membrane protein
Tissue Specificity Detected in heart (at protein level). Skeletal and cardiac muscle.
Database Links

KEGG: cfa:403776

UniGene: Cfa.2651

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