Recombinant Fundulus heteroclitus Type II iodothyronine deiodinase (dio2)

Code CSB-CF301283FDK
Size Pls inquire
Source in vitro E.coli expression system
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Product Details

Target Names
dio2
Uniprot No.
Alternative Names
dio2; Type II iodothyronine deiodinase; 5DII; DIOII; Type 2 DI; Type-II 5'-deiodinase
Species
Fundulus heteroclitus (Killifish) (Mummichog)
Expression Region
1-266
Target Protein Sequence
MGSASEDLLVTLQILPGFFSNCLFLALYDSVVLVKRVVALLSRSRSAGCGEWRRMLTSEG LRSIWNSFLLDAHKQVKLGCEAPNSKVVKVPDGPRWSSTVVPCGSRIQTGGECRLLDFES SDRPLVVNFGSATUPPFISHLPAFRQLVEDFSDVADFLLVYIDEAHPSDGWVAPQMGACS FSFRKHQNLEERIGAARKLIEHFSLPPQCQLVADCMDNNANVAYGVANERVCIVHQRKIA YLGGKGPFFYSLKDVRQWLELSYGRR
Protein Length
full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development.
Gene References into Functions
  1. Divergent evolution of dio2 paralogs supports organ-specific timing of the TH-dependent events governing the phenotypic plasticity required for migration to sea. PMID: 25802152
Subcellular Location
Membrane; Single-pass membrane protein.
Protein Families
Iodothyronine deiodinase family
Database Links

UniGene: Fhe.427

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