Recombinant Mouse ATP-sensitive inward rectifier potassium channel 1 (Kcnj1)

1. ENaC and ROMK channel activity in kidney tubules are inhibited in TgWnk4(pseudoaldosteronism type II) mice. Wnk4(PHAII)-induced inhibition of ENaC and ROMK may contribute to the suppression of K(+) secretion in the tubules. PMID: 28365586
2. animal knockouts of ROMK1 do not produce Bartter phenotype. ROMK1 is critical in response to high K intake-stimulated K+ secretion in the collecting tubule. PMID: 26728465
3. Lovastatin stimulates ROMK1 channels by inducing PI(4,5)P2 synthesis, suggesting that the drug could reduce cyclosporine-induced nephropathy. PMID: 25349201
4. It was concluded that miR-194 regulates ROMK channel activity by modulating ITSN1 expression thereby enhancing ITSN1/WNK-dependent endocytosis. PMID: 24197061
5. hypertension resistance sequence variants inhibit ROMK channel function by different mechanisms PMID: 20926634
6. knockout mice have impaired renal NaCl absorption; a model for type II Bartter's syndrome PMID: 12122007
7. Absence of small conductance K+ channel (SK) activity in apical membranes of thick ascending limb and cortical collecting duct in knockout mice a model for bartter's disease__ PMID: 12130653
8. ROMK is required for functional expression of the 70-pS K channel in the thick ascending limb. PMID: 14600033
9. mutant WNK4 does not have a dominant effect on the cellular localization of kidney ROMK PMID: 15907795
10. The expression of ROMK channels in the plasma membrane is regulated by PTK, SGK, and with-no-lysine-kinase 4. A recent study indicated that ROMK channels can be monoubiquitinated and monoubiquitination regulates the surface expression of ROMK channels. PMID: 16339961
11. Potassium absorption in the loop of Henle is reduced in Romk-deficient mice and can account for a significant fraction of renal potassium loss. PMID: 16710355
12. mRNA expression of ROMK is augmented in the renal medullary tubule by NaCl-induced hypertonicity through stimulation of ROMK gene transcription, and that TonEBP and the p38 MAPK and ERK pathways are involved in this effect. PMID: 17003571
13. Potassium restriction suppresses the expression of PP2B catalytic subunits and that inhibition of PP2B decreases ROMK channel activity. PMID: 18184875
14. adaptive changes in Romk(-/-) mice may help to limit renal Na(+) loss PMID: 18322017
15. absolute excretion of Na(+) and K(+) were significantly blunted in Romk(-/-) mice, consistent with a major salt transport defect in the thick ascending limb PMID: 18385266
16. more severe Bartter phenotype in female ROMK null mice, and higher PGE(2) and TXB(2) production may be one of the mechanisms of this manifestation PMID: 18579648
17. KS-WNK1 is an important physiological regulator of renal K(+) excretion, likely through its effects on the ROMK1 channel. PMID: 19244242
18. cortical collecting duct cells demonstrate a significant K(+) secretion, probably mediated by ROMK, which is not stimulated by aldosterone but increased by overnight exposure to a high K(+) concentration PMID: 19297448
19. We propose that in taste buds, ROMK in type I/glial-like cells may serve a homeostatic function, excreting excess K(+) through the apical pore, and allowing excitable taste cells to maintain a hyperpolarized resting membrane potential. PMID: 19708028
20. ARH marks ROMK for clathrin-dependent endocytosis, in concert with the demands of potassium homeostasis PMID: 19841541

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KEGG: mmu:56379

STRING: 10090.ENSMUSP00000131625

UniGene: Mm.390168