Recombinant Mouse CD83 antigen (Cd83)

1. orchestrated regulation of MHC II surface expression in thymic epithelial cells (TECs) by MARCH 8 and CD83 plays a major role in CD4(+) T cell selection. PMID: 27503069
2. CD83-mediated MHCII stabilization through antagonism of March8 as a novel functional adaptation of cortical epithelial cells for T cell selection. PMID: 27503071
3. results show that CD83 is important for B cell activation and modulates germinal center composition and IgE Ab responses in vivo PMID: 26983787
4. Our findings indicate that CD83 homotypic interactions regulate DC activation and promote mucosal homeostasis. PMID: 25204675
5. CD83(+) T cells share important features with regulatory T cells, identifying CD83 as a novel lineage marker to discriminate between different T cell populations. PMID: 25151500
6. CD83 differentially modulates follicular and marginal zone B cell responses PMID: 23728778
7. Dendritic cells co-cultivated with antigen-specific induced Tregs expressed lower levels of CD83. A major suppressive mechanism of DC function by iTregs is secondary to the effects of IL-10 on MARCH1 & CD83 expression. PMID: 24218453
8. activated T cells induce CD83 on B cells via CD40 engagement but independent of TCR/MHC binding and thus independent of antigen-specificity of B cells. PMID: 21277328
9. found that the transmembrane domain of CD83 enhances MHC class II and CD86 expression by blocking MHC class II association with the ubiquitin ligase MARCH1 PMID: 21220452
10. Data strongly suggest that CD83 is expressed by B cells upon activation and contributes to the regulation of B cell function. PMID: 17710154
11. Soluble CD83-Ig fusion protein is immunosuppressive, costimulatory when coimmobilized with anti-CD3, and by interacting with its ligand(s) is involved in regulation of immune response to tumor. PMID: 11884422
12. CD83 expression influences CD4+ T cell development in the thymus. PMID: 11955430
13. the soluble extracellular CD83 domain inhibits DC-mediated T-cell proliferation, representing the first report describing a functional role for CD83. PMID: 12072358
14. murine CD83 is expressed mainly on mature dendritic cells and on activated T cells PMID: 12687354
15. M2 cells expressing CD83 can induce a tumor-destructive immune response also against SW1 cells and that this response can be made more effective by combining them with M2 cells expressing anti-CD137 scFv PMID: 15051893
16. analysis of monomeric and dimeric isoforms of CD83 PMID: 15721284
17. thymic selection in the presence of CD83-immunoglobulin leads to an intrinsic T cell defect of CD4-positive T cells resembling the phenotype described for CD4-positive T cells derived from CD83-deficient mouse strains PMID: 16841299
18. CD83 is expressed on murine B cells upon activation and is involved in the regulation of humoral responses. PMID: 17266176
19. Expression on T cells and dendritic cells modulates the immune response by activating dendritic cells and by delivering costimulatory signals for the stimulation of T cells. PMID: 17301951
20. These studies further emphasize a role for CD83 in lymphocyte development and immune regulation and reveal an unexpected role for CD83 expression in influencing cell-surface MHC class II turnover. PMID: 17804692
21. CD83 is a functionally significant and sensitive marker of early lymphocyte activation in vivo PMID: 17878352
22. CD83 expression can contribute to the immunosuppressive function of CD4(+) T cells in vivo. PMID: 18424708
23. CD83 expression levels did not significantly affect the capacity of the APC to activate CD8(+) or T cellsCD4(+) T cell activation PMID: 18675848
24. provide much needed clarification of the true nature of CD83 promoter activity PMID: 18701714
25. CD83 serves as a substrate of gene related to anergy in lymphocytes (GRAIL) protein and plays a role in CD4 T cell activation. PMID: 19542455

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KEGG: mmu:12522

STRING: 10090.ENSMUSP00000015540

UniGene: Mm.57175