Recombinant Mouse Emerin (Emd)

1. these data indicate that Emerin, a conserved nuclear lamina protein, couples extracellular matrix mechanics and SRF-Mkl1-dependent transcription. PMID: 28576971
2. Emerin-null progenitors were delayed in their cell cycle exit, had decreased myosin heavy chain (MyHC) expression and formed fewer myotubes. Emerin binds to and activates histone deacetylase 3 (HDAC3). PMID: 28188262
3. changes in nuclear size and shape, which are mediated by nuclear envelope structural proteins lamin A/C and/or emerin, also impact gene regulation and lineage differentiation in early embryos. PMID: 28088180
4. Results suggest that emerin protein is an essential component of the cellular apparatus constraining and fine-tuning Wnt/b-catenin signaling in the heart providing tight control of cardiomyocyte numbers. PMID: 25274778
5. emerin functions with myosin IIB to polarize actin flow and nuclear movement in fibroblasts, suggesting a novel function for the nuclear envelope in organizing directional actin flow and cytoplasmic polarity. PMID: 24152738
6. Interactions between HDAC3 and Emerin mediate the interaction of myogenic regulatory loci with the nuclear lamina. PMID: 24062260
7. a novel mechanism that could provide insight into the disease aetiology for the cardiac phenotype in many laminopathies, whereby lamin A/C and emerin regulate gene expression through modulation of nuclear and cytoskeletal actin polymerization PMID: 23644458
8. report significant perturbations in the expression and activation of p38/Mapk14 in emerin-null myogenic progenitors, showing that perturbed expression of Wnt, IGF-1, TGF-beta, and Notch signaling components disrupts normal downstream myogenic signaling PMID: 22606356
9. emerin facilitates repressive chromatin formation at the nuclear periphery by increasing the catalytic activity of HDAC PMID: 22570481
10. These findings suggest roles for emerin as a downstream effector and signal integrator for tyrosine kinase signaling pathway(s) at the nuclear envelope. PMID: 19789182
11. emerin and lamin A/C are bound to actin at the late stages of myotube differentiation PMID: 12670476
12. the lamin a-emerin complex might have a role in muscular dystrophy and cardiomyopathy PMID: 12783988
13. Data show that emerin-deficient mouse embryo fibroblasts have apparently normal nuclear mechanics but impaired expression of mechanosensitive genes in response to strain. PMID: 16115958
14. Emerin deficiency causes minimal motor and cardiac dysfunctions in mice with a structural fragility of myonuclei. PMID: 16507906
15. Altered nuclear envelope elasticity caused by loss of emerin could contribute to increased nuclear fragility in Emery-Dreifuss muscular dystrophy patients with mutations in the emerin gene. PMID: 16997877
16. Data show that both downregulation of LUMA and overexpression of dominant-negative acting LUMA fragments causes redistribution of emerin. PMID: 18230648
17. Knockdown of A-type lamins and emerin in HeLa and C2C12 stimulated phosphorylation and nuclear translocation of ERK as well as activation of genes encoding downstream transcription factors. PMID: 19022376
18. Deregulation of cell signaling contributes to nuclear envelope-linked disorders and suggests that mutations in NET25 and MAN1 may cause muscle diseases. PMID: 19720741

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KEGG: mmu:13726

STRING: 10090.ENSMUSP00000002029

UniGene: Mm.18892