Recombinant Mouse Epsilon-sarcoglycan (Sgce)

1. Sgcem+/pGt mice show germline absence of major and brain-specific isoforms harboring exons 3' to intron 9. Sgce was maternally-imprinted in our mouse model. Sgcem+/pGt mice exhibited tiptoe walking and occasional stimulus-induced appendicular flexion posturing preweanling. Adult Sgcem+/pGt mice showed increased slips on a raised-beam task, anxiety-like behavioral abnormalities, and narrowed hindlimb stance widths. PMID: 27890709
2. The results suggest that varepsilon-sarcoglycan in the cerebellar Purkinje cells contributes to the motor learning, while loss of varepsilon-sarcoglycan in other brain regions may contribute to nuclear envelope abnormality, myoclonus and motor coordination deficits. PMID: 22040906
3. results suggest that the loss of epsilon-sarcoglycan in the striatum contributes to motor deficits, while it alone does not produce abnormal nuclear envelopes or myoclonus PMID: 22080833
4. impaired ectodomain shedding of M68T, a process that occurs physiologically for epsilon-sarcoglycan resulting in the lysosomal trafficking of the intracellular C-terminal domain of the protein. ( epsilon-sarcoglycan ) PMID: 21796726
5. Data describe mice carrying mutations in both Dyt1 and Sgce and show that these double mutant mice show earlier onset of motor deficits in beam-walking test. PMID: 20627944
6. Sgce gene is imprinted, with exclusive expression from the paternal allele. PMID: 16099459
7. These results suggest that the two epsilon-SG isoforms might play different roles in synaptic functions of the central nervous system. PMID: 15193417
8. High expression levels of epsilon-sarcoglycan mRNA and protein were found in the mitral cell layer of the olfactory bulb, the Purkinje cell layer in cerebellum, and the monoaminergic neurons in the mouse midbrain. PMID: 15612018
9. diverse symptoms associated with myoclonus-dystonia are indeed resulted from a single SGCE gene mutation that leads to alterations of dopaminergic and serotonergic systems. PMID: 16815860
10. Data demonstrate a novel function of the sarcoglycan complex in whole body glucose homeostasis and skeletal muscle metabolism, suggesting that the impairment of the skeletal muscle metabolism influences the pathogenesis of muscular dystrophy. PMID: 19494113

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KEGG: mmu:20392

UniGene: Mm.8739