Recombinant Mouse High affinity immunoglobulin gamma Fc receptor I (Fcgr1)

1. FcgammaRI plays a role on macrophages to involve in renal inflammatory response, potentially via regulating the NLRP3 inflammasome-associated signaling. PMID: 30190171
2. investigated consequences of 3 nonsynonymous SNPs for FcgammaRI; only SNP V39I reduces immune-complex binding of FcgammaRI whereas monomeric IgG binding is unaffected; SNPs I301M and I338T have no influence on monomeric IgG or immune complex binding, but FcRgamma signaling is decreased for both SNPs PMID: 28814603
3. FcgammaRI/FcgammaRIIB expression ratio in splenic macrophages was higher in the Treg-deficient immune thrombocytopenia (ITP) than in the Treg-deficient non-ITP and control mice PMID: 28028748
4. The IgG2 immune complexes activates osteoclastogenesis by binding to FcgammaRI. PMID: 25824719
5. Dbn1 regulates systemic anaphylaxis and IgE/Fcgr1-induced degranulation in mast cells by regulating actin reorganization and actin dynamics. PMID: 26056254
6. This study demonstrated that the activating FcgammaRs-mediated inflammation plays a critical role in anti-ganglioside Abs-induced neuropathy (injury to intact nerve fibers) in GBS. PMID: 25926454
7. N-glycans in FcgammaRIa interact with the OmpA of E. coli K1 for inducing disease pathogenesis PMID: 25231998
8. observations suggest that IgG-mediated inhibition of fibrocyte differentiation is mediated by FcgammaRs, with FcgammaRI mediating most of the signaling. PMID: 24752483
9. Inhibition of GCH1 prevented the Escherichia coli K1 induced expression of CD64 in macrophages in vitro and the development of bacteremia in a newborn mouse model of meningitis. PMID: 24161960
10. The PI3K inhibitor LY294002 inhibited BCR-mediated, but not TLR-mediated, induction of IkappaB-zeta, consistent with the role of PI3K in BCR signaling and its suppression by FcgammaR. PMID: 23728777
11. Tpl2 is activated by FcgammaR signals in macrophages and that its activation by these signals is required for ERK activation, cytoplasmic Ca(2+) influx, the induction of cytokine and coreceptor gene expression, and phagocytosis. PMID: 23898046
12. FcgammaRI partially mediates the protective effect of monoclonal antibody TA99 on metastatic melanoma tumor loads. PMID: 23150715
13. observations suggest that serum amyloid P, at least in part, uses FcgammaRI and FcRgamma to inhibit fibrocyte differentiation PMID: 22493081
14. CRP antagonism of eNOS is mediated by coupling of FcgammaRI to FcgammaRIIB by Src kinase and activation of inositol 5'-phosphatase 1, and consistent with this mechanism, both FcgammaRI and FcgammaRIIB are required for CRP to blunt endothelial repair in vivo. PMID: 21940940
15. IgG FcgammaRI (CD64) is a target of miR-127, as evidenced by reduced CD64 protein expression in macrophages overexpressing miR-127. PMID: 22287715
16. This review notes that the role of murine FcgammaRI differs considerably from human, based on sequence data, existence of the FcgammaRI variable region, and overview of disease models. PMID: 21325219
17. CD64 expression in macrophages is critical for the onset of meningitis by Escherichia coli K1. PMID: 21124939
18. Alveolar macrophages and Fc receptors (Fcgr1 and Fcgr3)-dependent elimination of influenza A virus-infected cells are essential for protection by influenza A virus anti-matrix protein 2 (M2) ectodomain IgG antibody. PMID: 21169548
19. Studies identified the extracellular signal-regulated kinase (ERK 1/2) signaling pathway as a mediator of signals from FcgammaR activation to cyclin D1. PMID: 19996316
20. FcgammaRI is an early participant in Fc-dependent cell activation and in the development of immune responses PMID: 11911823
21. FcgammaRI(-/-) mice showed impaired hypersensitivity responses, strongly reduced cartilage destruction in an arthritis model, and impaired protection from a bacterial infection PMID: 11911824
22. The expression of FcgammaRI controls cytokine and chemokine expression late in the development of proteoglycan-induced arthritis during the onset of disease. PMID: 12421967
23. mesangial cells express Fcgamma receptors in vitro, but they have no role in an FcRgamma-dependent model of glomerulonephritis in vivo. PMID: 12427132
24. This receptor mediates disease in accelerated nephrotoxic nephritis. (disease is prevented in knockout mice) PMID: 12707052
25. These results indicate that interferon-gamma overexpression enhances cartilage destruction in the presence of immune complexes and that FcgammaRI is crucial in the development of chondrocyte death. PMID: 12875993
26. Recent studies now indicate that FcRgamma expression in gammadelta T cells, most likely as a component of the TCR/CD3 signaling complex, is a critical requirement for experimental autoimmune encephalomyelitis development. PMID: 14991835
27. The cytoplasmic domain of CD64 alpha-chain modulates transcriptional activity induced by receptor-specific engagement in macrophages. PMID: 15528358
28. Data suggest that the FcRgamma chain is not essential for induction of experimental allergic encephalomyelitis, but that FcRgamma signaling may contribute to the preclinical phase. PMID: 15835266
29. The role of the collagen receptor glycoprotein VI (GPVI) in arteriolar thrombus formation was studied in FcRgamma-null mice (FcRgamma(-/-)) lacking platelet surface GPVI PMID: 16455953
30. Inhibition of Ras/Erk or PI3K suppressed the enhanced production of IL-6 in SHIP-deficient macrophages. In contrast, inhibition of Ras/Erk, but not PI3K, suppressed IL-1beta production in these cells PMID: 16543474
31. Regulates host IgG levels and transports IgG and associated antigens across polarized epithelial barriers. PMID: 16841095
32. A role for FcR gamma is defined in the facilitation of engrafted allogeneic stem cell reconstitution; FcR gamma is a critical part of the T cell receptor beta-FCp33 complex uniquely expressed on facilitating cells (FCs). PMID: 16849450
33. FcRI and FcRIII activation in leukocytes and vascular smooth muscle cells are involved in the antigen-antibody complex-mediated responses during atherogenesis. PMID: 17053192
34. FcgammaRI plays an important role but is not the sole mediator of CRP-mediated protection from nephrotoxic nephritis. PMID: 17182593
35. The activity of IgG-G0 antibody glycovariants is fully dependent on the presence of activating Fc receptors. PMID: 17485663
36. IgG1 Allo-monoclonal major histocompatibility complex class I antigens can augment graft injury by activating mononuclear cells through their Fc receptors. PMID: 18049118
37. The respective roles of FcgammaRI, FcgammaRIII, and FcgammaRIV in in the development of autoimmune hemolytic anemia were shown. PMID: 18209093
38. FcgammaRI and FcgammaRIII were together dispensable for the development of destructive arthritis but the FcR gamma-chain was not, suggesting a role for another FcR gamma-chain associated receptor, most likely FcgammaRIV PMID: 18354234
39. Cooperative FcgammaRIV, FcgammaRIII, and FcgammaRI interactions mediated optimal lymphoma depletion by CD20 mAb in vivo. PMID: 18495955
40. These results identify PLCgamma2 as a critical player of integrin and Fc receptor-mediated neutrophil functions and the neutrophil-mediated effector phase of autoimmune arthritis. PMID: 19273622

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KEGG: mmu:14129

STRING: 10090.ENSMUSP00000029748

UniGene: Mm.150