Recombinant Mouse Interleukin-6 receptor subunit alpha (Il6ra)

1. Data (including data from studies using transgenic/knockout mice) suggest that signaling via IL6/IL6R couples autophagy to antioxidant response in insulin-secreting cells. (IL6 = interleukin-6; IL6R = interleukin-6 receptor) PMID: 29784660
2. In the CNS, LPS administration had the greatest effect on IL-6R mRNA. PMID: 28456715
3. IL-6 Receptor is overexpressed in glioma, and it can be used for targeted delivery of the therapeutic ING4 to the tumor. PMID: 28502470
4. role for IL-6R expression in regulating RBC alloimmunization PMID: 27662015
5. There are functional interleukin-6 receptor-alpha on tanycytes at the bottom of the third ventricle, in agreement with the possibility that ventricular administration of IL-6 decreases obesity in mice via an effect on this cell type. PMID: 29024103
6. we present evidence for the role of M2 phenotype TAM in IL-6 receptor-mediated signals, particularly tyrosine phosphorylation of STAT3, responsible for the prosurvival adaptation of tumor cells to hypoxia. PMID: 26705936
7. Blockade of the IL-6R receptor by the monoclonal MR16-1 antibody for four weeks started directly after I/R injury did not prevent the process of cardiac remodeling in mice, but rather associated with a deterioration in the process of adverse cardiac remodeling. PMID: 27936014
8. TNF/IL-6 generated osteoclasts in vitro that resorbed mineralized tissue through a pathway dependent on IL-6R, NFATc1, DNAX-activation protein 12, and cell proliferation PMID: 27563728
9. C2C12 myotubes possesses a mechanism for regulating IL-6R and gp130 expression following lipoic acid treatment or heat shock. PMID: 27086282
10. Interleukin-6 receptor alpha may have a role in skin lesions in a murine model of systemic lupus erythematosus PMID: 26739431
11. findings identify TRAF3 and PTPN22 as inhibitors of IL-6R signaling in B cells and reveal a previously uncharacterized role for TRAF3 in the regulation of plasma cell differentiation PMID: 26329582
12. Data show that blockade of interleukin-6 receptor by an anti-IL-6R antibody can augment the anti-arthritic effect of glucocorticoids (GCs) and inhibit the bone loss they cause. PMID: 26201536
13. established that endogenous IL-6R of both human and murine origin is shed by ADAM17 in an induced manner, whereas constitutive release of endogenous IL-6R is largely mediated by ADAM10 PMID: 26359498
14. Increased expression of the Th17-IL-6R/pSTAT3/BATF/RorgammaT-axis in the tumoural region of adenocarcinoma as compared to squamous cell carcinoma of the lung PMID: 25491772
15. When endogenously released IL-6 binds to Il-6Ralpha in brain the effect is pyrogenic. PMID: 25429137
16. Cellular senescence or EGFR signaling induces Interleukin 6 receptor expression controlled by mTOR. PMID: 24047696
17. IL-6Ralpha deficiency activates PP-1alpha and Mule expression, resulting in increased Mcl-1 turnover and protection against HCC development. PMID: 23954788
18. identify the transcription factor Twist1 as a component of a STAT3-induced feedback loop that controls IL-6 signals by directly repressing Il6ra. PMID: 23935104
19. Disruption of interleukin-6 receptor signaling is an effective strategy for modulating proinflammatory immune responses and preventing chronic rejection. PMID: 22758208
20. Il6r alpha is co-localized with melanin-concentrating hormone in mouse hypothalamus. PMID: 22295972
21. describe an unexpected species specificity of ADAM10 and ADAM17 and identified ADAM10 as novel inducible sheddase of IL-6R in mice and humans, which might have consequences for the interpretation of phenotypes from ADAM17- and ADAM10-deficient mice PMID: 21454673
22. The synergistic effect of IL-17 and the IL-6 receptor on IL-6 gene expression involves numerous signaling pathways. PMID: 20351184
23. Data demonstrate that after ADAM17 mediated cleavage, the IL6R C-terminal fragment is cleaved by gamma-secretase at the plasma membrane. PMID: 20026129
24. Classical IL-6R signaling in central memory CD4-positive T cells is required to steer their effector characteristics, whereas local regulation of soluble IL-6R activity might serve to maintain the cytokine profile of the T helper cell infiltrate. PMID: 20083667
25. Lamina propria macrophage-derived interleukin (IL)-6/IL-6R alpha chain play a specific role in the development of colitis-associated premalignant cancer. PMID: 20042582
26. The requirement for the IL-6 receptor chain may render p28/cytokine-like factor (CLF) 1/ more specific for T cells than IL-27. PMID: 19933857
27. A point mutation of Tyr-759 in subunit gp130 causes autoimmune arthritis. PMID: 12370259
28. downregulation by prostaglandin E2 resulting in growth arrest of NFS-60 cells PMID: 12429018
29. IL6 ligand plus IL6 receptor activate the p0 promoter and myelin basic protein PMID: 12643284
30. Airway epithelial cell IL-6 and soluble IL-6 receptor alpha participate in inflammatory trans-signaling in response to bacterial pathogens. PMID: 16034137
31. elevated IL-6Ralpha expression by a subset of CD8(+) T cells represents an early imprint of CD4(+) T cell helper function that actively contributes to the survival of activated CD8(+) T cells PMID: 17202339
32. IL-6 receptor expression increases during in vitro osteoblast differentiation and that IL-6 functions as a differentiation regulator of preosteoblast cells and an apoptosis initiator in more mature cells PMID: 18555695
33. Report downregulation of cilia-localized Il-6R alpha by 17beta-estradiol in mouse and human fallopian tubes. PMID: 19420002
34. Blockade of IL-6R directly affects osteoclast formation in vitro and in vivo, suggesting a direct and specific effect of anti-IL-6R therapy on osteoclasts independently of its antiinflammatory effects. PMID: 19714627

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KEGG: mmu:16194

STRING: 10090.ENSMUSP00000029559

UniGene: Mm.2856