Recombinant Mouse Phosphatidylethanolamine N-methyltransferase (Pemt)

1. fenofibrate partially reversed hepatic steatosis and fibrosis in Pemt(-/-) mice when treatment was initiated after nonalcoholic fatty liver disease (NAFLD) had already been established. Increasing hepatic fatty acid oxidation can compensate for the lower VLDL-triacylglycerol secretion rate and prevent/reverse fatty liver disease in mice lacking PEMT. PMID: 28159867
2. Results show that hepatic PEMT protein levels and activity are post-translationally repressed in homocystinuria and correlates with decreased phosphatidylcholine. PMID: 28291718
3. Activation of PPARgamma using pioglitazone in high fat diet-fed Pemt(-/-) mice improved liver function, while these mice were still protected against diet-induced obesity and insulin resistance. PMID: 26797396
4. Results showed that Pemt deficiency and high-fat diet in mouse model demonstrated the phenotypes resemble to the clinical features of the patients with lean non-alcoholic steatohepatitis. PMID: 26883167
5. propose that cold-induced hypothermia in HF-fed Pemt(-/-) mice is linked to plasma hypoglycemia due to compromised hepatic glucose production. PMID: 26113536
6. Lack of PEMT in mice does not promote fatty acid oxidation in skeletal muscle. PMID: 26603903
7. Decreased lipogenesis in white adipose tissue may contribute to the resistance to diet-induced obesity in Pemt(-/-) mice. PMID: 25463480
8. these findings indicate that the inhibition of Pemt activity ameliorates the ER stress associated with diabetic nephropathy in a model of type 1 diabetes PMID: 24667182
9. This study evaluated the role of the role of phosphatidylethanolamine N-methyltransferase in hepatic carbohydrate metabolism in chow-fed mice. PMID: 24677714
10. Pemt deficiency results in attenuated secretion of very low-density lipoproteins and homocysteine as well as in increased susceptibility to nonalcoholic liver disease. PMID: 22877991
11. Lack of phosphatidylethanolamine N-methyltransferase decreased liver damage in Abcb4(-/-) mice caused by exposure of the liver to excess bile acids. PMID: 21292027
12. Treatment strategies aimed at inhibition of PEMT might prevent the accumulation of cardiac triacylglycerol that predisposes individuals to compromised cardiac function. PMID: 21273556
13. de novo synthesis of choline via PEMT has a previously unappreciated role in regulating whole body energy metabolism. PMID: 20452975
14. During differentiation of 3T3-L1 cells to adipocytes, the amount of Sp1 protein decreased by approximately 50% just prior to activation of PEMT. PMID: 20150657
15. Dietary docosahexaenoic acid supplementation modulates hippocampal development in the Pemt-/- mouse. PMID: 19889625
16. PEMT is required in the secretion of apoB100-containing VLDLs. PMID: 12193594
17. Results show that phosphatidylethanolamine N -methyltransferase (PEMT) knockout mice do not display normal concentrations of choline metabolites even with a supplemental source of dietary choline. PMID: 12466019
18. Plasma homocysteine is regulated by phospholipid methylation, and is therefore lowered in enzyme-deficient mice. PMID: 12482759
19. PEMT activity is involved in many physiologic processes including the flux of lipid between liver and plasma and the delivery of essential fatty acids to blood and peripheral tissues via the liver-derived lipoproteins PMID: 14608048
20. This study observed increased numbers of phosphorylated histone H3 positive cells in the Pemt-/- mice (up 54% compared to wild-type mice; p<0.01). We also found decreased calretinin labeling in Pemt-/- (down to 43% compared to wild-type mice; p<0.01). PMID: 15063092
21. deficiency causes severe liver damage in conjunction with choline-deficient diet PMID: 15164765
22. Mouse PEMT genes have three unique transcription start sites, which are indicative of either multiple promoters and/or alternative splicing. PMID: 17456783
23. We conclude that the biosynthesis of PC via the PEMT pathway is not quantitatively essential for biliary PC secretion under acute or chronic bile salt administration. PMID: 17595447
24. Hepatic phosphatidylethanolamine N-methyltransferase has roles in animal biochemistry and physiology [review] PMID: 17881348
25. PEMT is involved in the regulation of plasma HDL levels in mice, mainly via HDL lipid uptake by SR-BI. PMID: 18842588
26. Lack of phosphatidylethanolamine N-methyltransferase alters plasma VLDL phospholipids and attenuates atherosclerosis in mice. PMID: 19520976

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KEGG: mmu:18618

STRING: 10090.ENSMUSP00000000310

UniGene: Mm.2731