Recombinant Mouse Potassium channel subfamily K member 2 (Kcnk2)

1. Data demonstrate that inhibition of TWIK-related K(+) channel-1 (TREK-1) protects mice from cognitive impairment induced by anesthesia and TREK-1 is a potential therapeutic target against memory impairment induced by volatile anesthetics. PMID: 29042297
2. data reveal a druggable K2P site that stabilizes the C-type gate 'leak mode' and provide direct evidence for K2P selectivity filter gating PMID: 28693035
3. Hyperoxia treatment of TREK-1/TREK-2/TRAAK-deficient mice is associated with a reduction in surfactant proteins PMID: 28839101
4. TREK-1 deficiency promoted neurons and oligodendrocytes apoptosis, aggravated demyelination and retarded motor recovery following spinal cord injury. PMID: 28192611
5. essential for normal sinoatrial node cell excitability PMID: 27098968
6. Formation of TREK-1/TREK-2 channels was also demonstrated in native dorsal root ganglion neurons indicating that heterodimerization may provide greater diversity of leak K(+) conductances also in native tissues. PMID: 27129242
7. Trek1 expression facilitates the restoration of intestinal epithelial barrier functions in an allergic environment. PMID: 25683610
8. Data suggest that porosome-associated proteins SNAP25, TREK-1, syntaxin-1A, and Gai3 exhibit stability and functionality such that isolated proteins can be reconstituted as insulin-secreting porosomes in cell membrane of live cells. PMID: 26523491
9. Data indicate that arginine vasopressin (AVP) and corticotropin-releasing hormone (CRH) show additive effects on the suppression of the potassium channel subfamily K member 2 TREK-1 current via protein kinase C. PMID: 26248219
10. In TREK1-deficient mice, brain endothelial cells displayed an inflammatory phenotype. PMID: 24557892
11. provide new insight into membrane targeting of TREK-1 in the heart and establish a broader role for beta(IV)-spectrin in organizing functional membrane domains critical for normal heart function PMID: 24445605
12. TREK-1 channels significantly contribute to the responsiveness of Grueneberg ganglion neurons to cool temperatures. PMID: 24101433
13. direct activation of the TREK-1 K(+) channel, acting downstream from the mu opioid receptor, might have strong analgesic effects without opioid-like adverse effects PMID: 24346231
14. TREK-M inhibits neuronal firing by hyperpolarizing the resting membrane potential and decreasing input resistance. Delivery of TREK-M could reduce the duration of status epilepticus and reduce neuronal death. PMID: 24299204
15. TREK1 knockout mice exhibit altered retinal waves. PMID: 23390312
16. TREK-1 is directly sensitive to membrane tension. PMID: 23897808
17. study analyzed the role of TWIK-related potassium channel-1 (TREK1)in endothelial cells and the blood-brain barrier(BBB); blocking TREK1 increased leukocyte transmigration; TREK1 activation had the opposite effect; results suggest an ion channel expressed by endothelial cells at the BBB regulates immune cell trafficking into the inflamed CNS PMID: 23933981
18. Polycystins protect renal epithelial cells against apoptosis in response to mechanical stress, and this function is mediated through the opening of stretch-activated K(2P) channels. PMID: 22832196
19. Trek-1 deficiency decreased IL-6 secretion from mouse and human alveolar epithelial cells at both transcriptional and translational levels PMID: 23275623
20. Ultrastructural analyses demonstrate that TREK-1 is preferentially localized at cell body and processes, whereas Best1 is mostly found in microdomains of astrocytes near synapses. PMID: 23021213
21. This review presented that the TERK-1 knockout mice show a correlation between 5-HT firing rate and PMID: 23089640
22. A mechanism for signal transduction within K(2P)2.1 (TREK-1) in which there is a clear crosstalk between the C-type gate and intracellular Ct domain. PMID: 22728824
23. Mice that did not express TREK-1 had lower decompression sickness resistance and were more likely to develop neurological symptoms PMID: 22323654
24. TREK-1 was expressed and could be detected on smooth muscle cells surrounding intrapulmonary airways and blood vessels. PMID: 21822716
25. Popdc1 and Popdc2 proteins interact with the potassium channel TREK-1, which leads to increased cell surface expression and enhanced current density PMID: 22354168
26. Expression of Trek-1 was significantly downregulated in cultured cells and lungs of mice exposed to hyperoxia.In MLE-12 cells Trek-1 defficiency resulted in increased cell proliferation and upregulation of PCNA and decrease of IL-6 and RANTES secretion. PMID: 21949155
27. TREK-1-expressing cells are more prevalent in lumbosacral than thoracolumbar ganglia in both bladder- and colon-dorsal root ganglia neurons. PMID: 21549810
28. Our results define a unique gating mechanism shared by K2P family members such as TREK-1 and suggest that their diverse sensory properties are achieved by coupling different molecular sensors to a conserved core gating apparatus. PMID: 21765396
29. Our data suggest that uterine excitability and contractility during pregnancy is regulated by the expression of SDK/TREK-1 channels. PMID: 21224218
30. Data suggest that the current is mediated via TWIK-related K(+) channel (TREK)-1 channels. PMID: 21343252
31. Report thermodynamic analysis of mouse TREK-1 gating and functional testing of several deletion mutants and compare to structural models. PMID: 21057213
32. TREK-1 expression does not provide brain protection after traumatic brain injury. PMID: 21157470
33. inhibition of TREK1 current by fluoxetine is found to be accompanied by dissociation of the C-terminal domain from the membrane. PMID: 21262820
34. Data identify a splice variant of TREK1 expressed in the brain, which encodes a heavily truncated TREK1 protein retaining a single transmembrane domain, having no channel activity itself but reduced TREK1 whole cell current amplitude. PMID: 20605797
35. Conclude that regulation of arterial diameter is not altered in mice lacking TREK-1. PMID: 20357027
36. Results describe the antidepressant effects of spadin, a secreted peptide derived from the propeptide generated by the maturation of the neurotensin receptor 3 (NTSR3/Sortilin) and acting through TREK-1 inhibition. PMID: 20405001
37. TREK channels may represent the AMPK-inhibited background K(+) channels that mediate activation of glomus cells by hypoxia. PMID: 19840997
38. protonation of the E306 residue tunes the TREK-1 mechanical setpoint and thus sets lipid sensitivity PMID: 12065410
39. TREK-1 is involved in neuroprotection and general anesthesia. PMID: 15175651
40. The TREK-1 channel protein was immunodetected in both nerve fibers and nerve cell bodies in the vestibular ganglion, both afferent fibers and nerve calyces innervating type I hair cells in the utricle and cristae. PMID: 15261098
41. TREK-1, TREK-2, and TRAAK are lysophosphatidic acid-operated K+ channels PMID: 15572365
42. Results demonstrate that membrane phospholipids, including PIP(2), control channel gating and transform TREK-1 into a leak potassium conductance. PMID: 15577940
43. TREK-1 markedly alters the cytoskeletal network and induces the formation of actin- and ezrin-rich membrane protrusions. PMID: 15976821
44. receptor- and kinase-induced inhibition of TREK-1 background potassium channels is mediated by sequential phosphorylation PMID: 16006563
45. primary observation is that the mechanosensitive K2P channels TREK-1 and TRAAK desensitize; desensitization and its regulation by chemical messengers is predicted to condition the physiological role of K2P channels PMID: 16636285
46. Results demonstrate that TREK-1 qualifies as one of the molecular sensors involved in pain perception. PMID: 16675954
47. The association of AKAP150 with TREK channels integrates them into a postsynaptic scaffold where both G-protein-coupled membrane receptors and TREK-1 dock simultaneously. PMID: 17110924
48. Deletion of TREK1 in mice leads to an important alteration in vasodilation of mesenteric arteries induced by acetylcholine and bradykinin. PMID: 17347672
49. selective expression and activation of TREK-1 in brain collaterals could play a significant role in the protective mechanisms of polyunsaturated fatty acids against stroke by providing residual circulation during ischemia. PMID: 17556656
50. the reduced sensitivity of glutamate and GABA release to inhibition by halothane in TREK-1 KO nerve terminals correlates with the reduced anaesthetic potency of halothane in TREK-1 KO mice PMID: 17828284

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KEGG: mmu:16526

STRING: 10090.ENSMUSP00000078416

UniGene: Mm.33304