Recombinant Mouse Potassium voltage-gated channel subfamily C member 1 (Kcnc1)

1. Kv3.1 channels stimulate adult neural precursor cell proliferation and neuronal differentiation. PMID: 23478135
2. The resting (closed) Kv3.1 channel conformation forms the high-affinity state for gambierol. PMID: 23401573
3. high-affinity multimeric binding between the Kv3.1 T1 domain and KIF5B requires three basic residues in the KIF5B tail. Kv3.1 T1 competes with the motor domain and microtubules, but not with kinesin light chain 1 (KLC1), for binding to the KIF5B tail. PMID: 23487040
4. Although all Kv3 transcripts were significantly expressed at embryonic age in whole brain extracts, only Kv3.1, Kv3.2 and Kv3.4 subunit proteins were present, suggesting a novel role for Kv3 channels at this developmental stage. PMID: 21912965
5. Block of Kv3.1 channels hinders spike repolarization and severely depresses evoked fast firing in deep cerebellar nuclear neurons. PMID: 21750937
6. Mice lacking both Kcnc1 and Kcnc2 genes fail to express the Kv3.1 and Kv3.2 channels in in the suprachiasmatic nucleus. PMID: 21414897
7. These results provide evidence that acoustically driven auditory activity can selectively regulate high-threshold potassium currents in the MNTB of normal hearing mice, likely due to an increased membrane expression of Kv3.1b channels. PMID: 20946234
8. As Kcnc1, but not Kcnc3, alleles are lost, mutant mice exhibit increasing gait ataxia accompanied by spike broadening and deceleration in deep cerebellar nuclei. neurons. PMID: 20016089
9. interaction with CALP/KCHIP4 PMID: 11847232
10. NCS-1 is an accessory subunit of Kv4-encoded I(to,f) channels that functions to regulate I(to,f) density in the mammalian myocardium. PMID: 11994284
11. Kv4.3, in association with K(+) channel-interacting proteins, is the major molecular determinant of A-type potassium current in murine colonic myocytes. PMID: 12381814
12. Modulation of the kv3.1b potassium channel isoform adjusts the fidelity of the firing pattern of auditory neurons. PMID: 12598601
13. Motor deficits and altered synaptic transmission at the parallel fiber-Purkinje cell synapse in Kv3.1 knockout mice. PMID: 12930807
14. Ongoing activity in auditory brainstem neurons is necessary for the maintenance of Kv3.1 tonotopicity through the CREB pathway PMID: 14985434
15. Double mutant Kv3.1/Kv3.3-deficient mice are constitutively hyperactive. Increased ambulatory and stereotypic activity in conjunction with sleep loss was seen in Kv3.1-single mutants but not in Kv3.3-single mutants. PMID: 15005717
16. Starburst amacrine cells have large outward currents which are mediated in part by the Kv3.1 channel. PMID: 15317859
17. all Renshaw cells expressed Kv3.1b weakly from postnatal day 14, and strongly at postnatal day 21. PMID: 16460880
18. two voltage-gated potassium channels, Kv3.1 and Kv3.3, control sleep in wild-type and Kv3-mutant mice PMID: 16553620
19. Calcineurin and NFATc3 constitute a Ca(2+)-driven signaling module that contributes to the nonuniform distribution of Kv4 expression, and hence Ito function, in the mouse left ventricle. PMID: 16614306
20. K(V)3.1 K(+) current accounts for significant component of total K(+) current in oligodendrocyte lineage and, in association with OSP/claudin-11, plays significant role in OPC proliferation and migration and myelination of axons. PMID: 16624990
21. results support the hypothesis that altered electrophysiological properties of TRN neurons contribute to the reduced EEG power at slow frequencies in the thalamocortical network of Kv3-deficient mice. PMID: 18495891
22. Kv3.1 expressed in both GAD- and GAD+ cells, albeit at different densities and distribution. They likely contribute to the distinct biophysical properties of both GAD- and GAD+ neurons in the dentate nucleus. PMID: 18682278

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KEGG: mmu:16502

STRING: 10090.ENSMUSP00000124938

UniGene: Mm.249386