Recombinant Mouse Prostaglandin E2 receptor EP1 subtype (Ptger1)

1. Loss of EP1 results in inactivation of Hif1alpha, increased oxygen consumption rate and thus increased osteoblast differentiation. PMID: 28444901
2. PGE2 serves as a central regulator of the Ren-1c gene in the principal cells of the kidney collecting ducts via the PKC/cAMP/CREB pathway. PMID: 28701311
3. Our study identifies the EP1 signaling pathway as an important link between neuroinflammation and MMP-mediated BBB breakdown in ischemic stroke. PMID: 26648273
4. EP1-/- mice maintain increased bone mineral density and stronger cortical and trabecular bone biomechanical properties with aging. The EP1 receptor acts to inhibit bone marrow osteoprogenitor cell differentiation and mineralization. PMID: 25446888
5. Results indicate that EP1 receptor activation during seizures, through a protein kinase C pathway, increases probability of kainic acid induced status epilepticus, and independently promotes hippocampal neurodegeneration and a broad inflammatory response PMID: 24952362
6. The EP1 receptor facilitates the actions of angiotensin II, thereby suggesting that targeting of both the renin-angiotensin system and the EP1 receptor could be beneficial in diabetic nephropathy. PMID: 24113456
7. Propose a mechanism whereby ANG II increases COX-1-derived PGE2 through the AT1R/PLA2 pathway, which promotes ROS production by EP1R/Nox2 signaling in the subfornical organ. PMID: 24014678
8. dietary administration and direct injection of the EP1 receptor-specific antagonist, ONO-8713, effectively reduced the growth of established CT26 tumors in BALB/c mice PMID: 23390011
9. EP1 deletion protects mice from asymmetrical Parkinsonism. The PGE2 EP1 receptor is implicated in 6-OHDA-induced Parkinsonism. PMID: 23385625
10. Data suggest that EP1 receptor blockade may be a viable target for antihypertensive therapy. PMID: 23006735
11. data suggest that the tumor promoting/progressing effects of EP1 require the PGE2 synthesized by COX-2 PMID: 21739481
12. Peripheral EP1 receptors contribute significantly to inflammation induced heat pain sensitization while evidence for a contribution to central sensitization was not obtained. PMID: 21440042
13. Upregulation of the EP1 receptor for prostaglandin E2 promotes skin tumor progression. PMID: 21268127
14. study provides firm evidence for the direct action of the PGE2-EP1 signaling on dopaminergic regulation in the midbrain. This EP1 action may explain the impulsive behaviors of Ptger1-/- mice due to a hyperdopaminergic state. PMID: 20092576
15. impaired adrenocorticotropic hormone response to bacterial endotoxin in mice deficient in this receptor PMID: 12642666
16. both the EP1 and the EP3 receptors play a role in fever induced by systemic inflammation but neither EP receptor is involved in the circadian rise in Tc or psychological stress-induced hyperthermia in mice. PMID: 12837930
17. EP(1) receptor is of major importance for colon cancer development and it could be a new target for a mechanism-based chemoprevention strategy against colon cancer development. PMID: 15564292
18. host EP1 and prostaglandin E receptor 3 receptors are involved in the control of local tumor growth, which translates into anorexia PMID: 15943039
19. the EP4 receptor mediates PGE2-induced renin secretion and that EP1, EP3, and EP4 receptors all contribute to enhanced PGE2-mediated salt and water excretion in the hyperprostaglandin E syndrome/antenatal Bartter syndrome model PMID: 15976003
20. prostaglandin E(2) acts through EP1 to control impulsive behavior under stress PMID: 16247016
21. EP1 receptors contribute to neurotoxicity by augmenting the Ca(2+) dysregulation underlying excitotoxic neuronal death PMID: 16432513
22. EP(1) does not appear to have a significant direct effect on airway tone but acts as a modulator of the beta(2)AR, altering G(alphas) coupling via steric interactions imposed by the EP(1):beta(2)AR heterodimeric signaling complex PMID: 16670773
23. These data suggest that PGE(2) modulates urine concentration by acting at EP(1) receptors, not in the collecting duct, but within the hypothalamus to promote AVP synthesis in response to acute water deprivation. PMID: 16885154
24. Changes in EP1 receptor expression and prostaglandin E2 secretion in hypoxic MC3T3-E1 cells are reported. PMID: 17370287
25. the prostanoid EP1 receptor plays a significant role in regulating CBF and neuronal cell death. PMID: 17600836
26. support the possibility of targeting the EP1 receptor for antihypertensive therapy PMID: 17710229
27. PGE2 produced by dendritic cells in the lymph nodes acts on EP1 in naive T cells to promote Th1 differentiation. PMID: 17967902
28. In urothelium, EP1 receptor may be important for reflex voiding in pathological conditions since it is present in the urothelium and is involved in the afferent limb. PMID: 18480552
29. These data strongly implicate a role for HIF-1alpha in hypoxia-induced EP1 expression PMID: 19277991
30. Activation of EP1 receptors increases arteriolar tone, which could contribute to the development of hypertension in the db/db mice. PMID: 19299433
31. prostaglandin E2 signaling via either EP1 or EP2 is largely to completely necessary for Toll-like receptor 4-dependent depletion of inttermediate progenitor cells from the hippocampal subgranular zone PMID: 19389932

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KEGG: mmu:19216

STRING: 10090.ENSMUSP00000019608

UniGene: Mm.213000