Recombinant Mouse Prostaglandin E2 receptor EP2 subtype (Ptger2)

Code CSB-CF730772MO
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Source in vitro E.coli expression system
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Product Details

Target Names
Ptger2
Uniprot No.
Alternative Names
Ptger2; Ptgerep2; Prostaglandin E2 receptor EP2 subtype; PGE receptor EP2 subtype; PGE2 receptor EP2 subtype; Prostanoid EP2 receptor
Species
Mus musculus (Mouse)
Expression Region
1-362
Target Protein Sequence
MDNFLNDSKLMEDCKSRQWLLSGESPAISSVMFSAGVLGNLIALALLARRWRGDTGCSAG SRTSISLFHVLVTELVLTDLLGTCLISPVVLASYSRNQTLVALAPESHACTYFAFTMTFF SLATMLMLFAMALERYLSIGYPYFYRRHLSRRGGLAVLPVIYGASLLFCSLPLLNYGEYV QYCPGTWCFIRHGRTAYLQLYATMLLLLIVAVLACNISVILNLIRMHRRSRRSRCGLSGS SLRGPGSRRRGERTSMAEETDHLILLAIMTITFAICSLPFTIFAYMDETSSLKEKWDLRA LRFLSVNSIIDPWVFAILRPPVLRLMRSVLCCRTSLRTQEAQQTSCSTQSSASKQTDLCG QL
Protein Length
full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle.
Gene References into Functions
  1. Results show in organotypic hippocampal slice cultures that inflammatory response to either Poly(I:C) or lipopolysaccharide (LPS) are mostly driven by TLR3 & TLR4, respectively, in a microglia-dependent fashion; indicate that activation of EP2 mediated diverse anti-inflammatory effects following Poly(I:C) and LPS challenge possibly by inhibiting molecular pathways with critical contributions in neurodegenerative diseases. PMID: 29226424
  2. The protective effect of the EP2 receptor on TGF-beta1 induced podocyte injury via the PI3K / Akt signaling pathway. PMID: 29746568
  3. EP2 contributes to generating mechanical hyperalgesia through positive feedback upregulation of COX-2 expression in muscle after lengthening contractions PMID: 28759126
  4. neuronal EP2 receptor activation by PGE2 protects brain against intracerebral hemorrhage injury in middle-aged mice through its anti-inflammatory and anti-oxidant effects and anti-MMP-2/9 activity PMID: 26746866
  5. data demonstrate that endogenous PGE2, EP2 receptors, and EPAC are prerequisites for maximal LPS-induced IL-33 expression and that exogenous PGE2 can amplify IL-33 production via EP2 and EP4 receptors. PMID: 28341741
  6. The data presented highlight a key role for EP2 and EP4 receptors in microvascular leak induced by PGE2. PMID: 26639895
  7. EP2 deficiency in MCs augmented TGF-beta1-induced fibronectin (FN), cyclooxygenase-2 (COX2), and CyclinD1 expression. Silencing of EP2 also strengthened TGF-beta1-induced extracellular-signal-regulated kinase 1/2 (ERK1/2) phosphorylation PMID: 26463992
  8. autocrine prostaglandin E2 signaling through EP receptors is essential for optimal CD4(+) T-cell activation. PMID: 26051593
  9. the blockade of EP2 and EP4 promotes mouse survival after cryptococcus infection by promoting the production of cytokines via TLR4, as well as the enhanced M1 polarization of alveolar macrophages PMID: 26122137
  10. The beneficial effect of both exogenous and endogenous PGE2 in aeroallergen-sensitized mice may be attributable to the activation of the EP2 receptor, which in turn acts as a restrainer of airway MC activity. PMID: 25823713
  11. Cardiac inflammation is reduced in EP-2-/- mice. PMID: 26305786
  12. Study suggests a deleterious role for the PGE2-EP2 signaling axis in modulating brain injury, inflammation, and functional recovery following intracerebral hemorrhage PMID: 25873308
  13. PGE2 was found to be the main prostaglandin in neurovascular coupling, with pyramidal neurons as their main cellular source. PMID: 26311764
  14. The main finding of this study is that PGE2 EP2-/- neurons are more susceptible to hemin neurotoxicity than WT neurons and that activation of the EP2 receptor protected neurons from hemin neurotoxicity. PMID: 25451967
  15. it should be clarified as to which EP and/or FP receptor signals are physiologically essential for myometrial contraction and successful parturition. PMID: 25480981
  16. regulation of CD36-mediated Abeta phagocytosis by suppression of EP2 signaling may provide a new approach to suppressing some aspects of Alzheimer disease pathogenesis PMID: 25452117
  17. Data indicate that the prostaglandin E2 receptor EP2-silencing RNA strongly enhanced MCs (mesangial cells) proliferation. PMID: 25327961
  18. These results indicate that EP2 activation, which initially promotes microglial activation, later causes delayed death of activated microglia, potentially contributing to the resolution phase of neuroinflammation. PMID: 25715797
  19. Multiple roles of the PGE2 -EP receptor signal in vascular permeability PMID: 24923772
  20. the prostaglandin E2/E-prostanoid receptor 4 pathway plays a key role in the activation of renal CD44+ mesenchymal stromal cell-like cells during conditions of juxtaglomerular recruitment PMID: 25776075
  21. Activation of the COX-2-PGE2-EP2 axis appears to be a specific response to FFSS in podocytes and provides a mechanistic basis for alteration in podocyte structure and the glomerular filtration barrier. PMID: 25234310
  22. RORgammat binds directly to Ptger2 (the gene encoding EP2 receptor) in Th17 cells PMID: 24812667
  23. Elastogenesis is spatially regulated by PGE-EP4 signaling in the ductus arteriosus. PMID: 24146253
  24. Prostaglandin E2 suppresses allergic sensitization and lung inflammation by targeting the EP2 receptor on T cells. PMID: 24075232
  25. PGE2 signaling by monocytes in the early preclinical phase promotes development of autoimmune encephalomyelitis in a prostanoid EP4 receptor-dependent manner. PMID: 24355567
  26. Data suggest expression of Ptger2/Ptgs2 (prostaglandin-endoperoxide synthase 2) is induced in cumulus cells of females sired by males with Y-chromosome long-arm deletion; paternal genes on Y-chromosome are involved indirectly in female reproduction. PMID: 22953728
  27. Fluid flow shear stress upregulates prostanoid receptor EP2 but not EP4 in murine podocytes. PMID: 23262148
  28. Together, these data identify a cell-specific proinflammatory role for macrophage/microglial EP2 signaling in innate immune responses systemically and in brain. PMID: 24089506
  29. PGE2 induces neuronal cell death by activation of EP2. PMID: 23514786
  30. EP2 deficiency in mice increases susceptibility to Mycobacterium tuberculosis infection, which correlated with reduced antigen-specific T-cell responses and increased levels of CD4(+)CD25(+)Foxp3(+) T-regulatory cells. PMID: 23033144
  31. Prostanoid receptor 2 signaling protects T helper 2 cells from BALB/c mice against activation-induced cell death. PMID: 22654101
  32. The data uncovered a previously unrecognized protective role of PTGS-2-derived PGE(2) in streptozotocin-induced diabetes mediated by PTGER2 and PTGER4. PMID: 22522619
  33. Together this supports a mechanism by which maturation and increased contractility of the vessel is coupled to the potent smooth muscle dilatory actions of PGE(2). PMID: 22342504
  34. Data show that E prostanoid receptor 2 (EP2)-deficient (EP2(-/-)) macrophages exhibited enhanced in vitro maturation compared with wild-type cells. PMID: 22234697
  35. The results of this study suggested that the PGE(2)-EP1 signaling is critical for susceptibility to repeated social defeat stress in mice through attenuation of mesocortical dopaminergic pathway. PMID: 22442093
  36. PGE2 suppresses natural killer functions in breast cancer-bearing hosts by acting on EP2 and EP4 receptors. PMID: 22306906
  37. COX-2-derived PGE(2) induces iNOS expression through cAMP/ERK pathways by activating EP(2) and EP(4) receptors in muscularis macrophages PMID: 22159280
  38. HMW HA can rescue TNBS-induced colitis through inducing Cox-2 and PGE(2) expressions in a TLR4-dependent way PMID: 21887846
  39. Neointimal hyperplasia was markedly accelerated in EP2-/- mice, which was associated with increased proliferation and migration of vascular smooth muscle cells and increased cyclin D1 expression in the neointima layer. PMID: 21636806
  40. Unlike the PGE(2) receptors EP2 and EP4, the EP1 receptor is a negative regulator that acts at multiple stages of the bone fracture healing process. PMID: 20939055
  41. EP2 receptor FuEP2/Ex2 may have a role in suppressing endometrial cancer cell growth PMID: 21419570
  42. Upregulation of COX-2 and EP2 levels by CD40 engagement was accompanied by dose-dependent phosphorylation of p38 and ERK1/2 mitogen-activated protein kinase. PMID: 20697426
  43. Data demonstrate that down-regulation of PTGER2 and consequent PGE2 resistance are both mediated by DNA hypermethylation; increased Akt signal transduction is a novel mechanism that promotes DNA hypermethylation during fibrogenesis. PMID: 20889571
  44. Data show a functional connection between PGE2 and beta-catenin nuclear translocation and connect these signaling pathways as part of the mechanism by which bone cells respond to fluid flow shear stress. PMID: 20713195
  45. The prostaglandin E2 receptor, EP2, stimulates keratinocyte proliferation in mouse skin by G protein-dependent and {beta}-arrestin1-dependent signaling pathways. PMID: 20959465
  46. Data show that donor engraftment is necessary for BMT-mediated reduction in age-related amyloid plaque formation in prostaglandin E2 receptor subtype 2-null mice, and that this is accompanied by reduced neurotoxic forms of amyloid peptides. PMID: 20522650
  47. Expression profiling of cumulus cells reveals functional changes during ovulation and central roles of prostaglandin EP2 receptor in cAMP signaling PMID: 20399827
  48. Data show that EP2 and EP4 function additively in EAE development. PMID: 20566843
  49. local EP2 and EP4 agonist treatment induces VEGF synthesis in the inner ear, especially in the spiral ganglion neurons; indicates the involvement of EP2 and EP4 in the autocrine and paracrine functions of VEGF in the cochlea PMID: 20219142
  50. PGE2 receptor EP2 mediates the antagonistic effect of COX-2 on TGF-beta signaling during mammary tumorigenesis PMID: 19897661

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Subcellular Location
Cell membrane; Multi-pass membrane protein.
Protein Families
G-protein coupled receptor 1 family
Database Links
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