Recombinant Mouse Protein ARV1 (Arv1)

Code CSB-CF883966MO
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Source in vitro E.coli expression system
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Product Details

Target Names
Arv1
Uniprot No.
Alternative Names
Arv1; Protein ARV1
Species
Mus musculus (Mouse)
Expression Region
1-266
Target Protein Sequence
MGTGGRRGTRSGKGTEGAAATSSSCLYRCIECNREAQELYRDYSHGVLKITICKSCQKPV DKYIEYDPVIILINAILCKTQAYRHILFNTKINIHGKLCMFCLLCEAYLRWWQLQDSSQS PAPDDVIRYAKEWDFYRMFVIASFEQAAFLTGIFAFLWVQQPMTAKRAPDFVLLLKALLL SSYGKLLLIPAVIWEHDYTPLCLRLIKVFVLTSNFQAVRVTLNTNRRLSLLVVLSGLLLE SIVVFFFQRMEWDVSSDCALYKSQDF
Protein Length
full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Plays a role as a mediator in the endoplasmic reticulum (ER) cholesterol and bile acid homeostasis. Participates in sterol transport out of the ER and distribution into plasma membranes.
Gene References into Functions
  1. In contrast to wild type human ARV1, neither variant expressed detectable levels of protein in mammalian cells. Mice with a neuronal deletion of Arv1 recapitulated the human phenotype, exhibiting seizures and a severe survival defect in adulthood. Our data support ARV1 deficiency as a cause of autosomal recessive epileptic encephalopathy PMID: 27270415
  2. These results implicate ARV1 as a protective factor in lipotoxic diseases due to modulation of fatty acid metabolism. PMID: 24273168
  3. Arv1p has a role in sterol movement from the ER and in the ensuing regulation of hepatic cholesterol and bile acid metabolism PMID: 20663892
Subcellular Location
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein Families
ARV1 family
Tissue Specificity
Ubiquitous. Highly expressed in lung.
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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