Recombinant Mouse Syndecan-2 (Sdc2)

Code CSB-CF020889MO
MSDS
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Source in vitro E.coli expression system
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Product Details

Target Names
Sdc2
Uniprot No.
Alternative Names
Sdc2; Hspg1; Synd2; Syndecan-2; SYND2; Fibroglycan; Heparan sulfate proteoglycan core protein; HSPG; CD antigen CD362
Species
Mus musculus (Mouse)
Expression Region
19-202
Target Protein Sequence
ETRTELTSDKDMYLDNSSIEEASGVYPIDDDDYSSASGSGADEDIESPVLTTSQLIPRIPLTSAASPKVETMTLKTQSITPAQTESPEETDKEEVDISEAEEKLGPAIKSTDVYTEKHSDNLFKRTEVLAAVIAGGVIGFLFAIFLILLLVYRMRKKDEGSYDLGERKPSSAAYQKAPTKEFYA
Protein Length
Full Length of Mature Protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
Cell surface proteoglycan that bears heparan sulfate. Regulates dendritic arbor morphogenesis.
Gene References into Functions
  1. We used a transgenic mouse model with high syndecan-2 expression in osteoblasts to enrich the bone surface with cellular glycosaminoglycans ..syndecan-2 overexpression increased apoptosis of mesenchymal precursors within the bone marrow PMID: 28661485
  2. Syndecan-2 expression is upregulated in colonic epithelia of mice with DSS-induced colitis via FOXO3 activation. PMID: 28031321
  3. In mouse melanoma cells, siRNA-mediated knockdown of syndecan-2 was associated with reduced melanin synthesis, whereas overexpression of syndecan-2 increased melanin synthesis. PMID: 24472179
  4. The repression of syndecan-2 by Wnt/beta-catenin/TCF signaling contributes to the resistance of osteosarcoma cells to doxorubicin. PMID: 22550000
  5. MC1R regulates melanoma cell migration via inhibition of syndecan-2 expression. PMID: 22493442
  6. Sarm1, a negative regulator of innate immunity, interacts with syndecan-2 and regulates neuronal morphogenesis. PMID: 21555464
  7. RGD-independent cell adhesion via a tissue transglutaminase 2-fibronectin matrix promotes fibronectin fibril deposition and requires syndecan-4/2 and {alpha}5{beta}1 integrin co-signaling. PMID: 20929862
  8. The role of syndecan-2 in regulation of actin-cytoskeletal organization of Lewis lung carcinoma-derived metastatic clones. PMID: 11931647
  9. role in dendritic spine morphogenesis PMID: 12073610
  10. Syndecan-2 mRNA transcripts are expressed by reactive astrocytes in the region surrounding the necrotic brain tissue, exhibiting peak levels at day 7 after cryo-injury. PMID: 12112370
  11. HSPG and LRP together participate in VLDL clearance by means of a synergistic relationship. PMID: 12598530
  12. syndecan-2 has a role in the integration of signals from soluble and insoluble factors PMID: 14642532
  13. In the present study, two Lewis lung carcinoma-derived clones express syndecan 2 and syndecan 4 cooperating in situ in actin cytoskeletal organization. PMID: 14999018
  14. Syndecan-2 is necessary for angiogenesis of microvascular endothelial cells, proangiogenic factors expressed during glioma progression regulate S2 shedding, and shed S2 ectodomain may increase endothelial cell angiogenic processes PMID: 16574663
  15. Study examined the effects of stable syndecan-2 overexpression on programmed cell death, finding that syndecan-2 transfected cells were more sensitive to apoptosis induced by serum-withdrawal than control cells. PMID: 17041758
  16. syndecan-2 acts as a suppressor for MMP-2 activation, causing suppression of metastasis PMID: 17623663
  17. Data show that unilateral nephrectomy leads to up-regulation of syndecan-2- and TGF-beta-mediated glomerulosclerosis in syndecan-4 deficient male mice. PMID: 17681770
  18. An alternate pathway mediated by the extracellular domains of syndecans-2 and -4 is characterized that is independent of both heparan sulphate and syndecan signaling. PMID: 17870067
  19. Syndecan-2 plays a crucial role in the migratory potential of melanoma cells. PMID: 19641225

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Subcellular Location
Membrane; Single-pass type I membrane protein.
Protein Families
Syndecan proteoglycan family
Tissue Specificity
Preferential expression in cells of mesenchymal origin.
Database Links
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