Recombinant Mouse Syntaxin-4 (Stx4)

1. Spontaneous membrane translocation of syntaxin-4 is critical for maintenance of embryonic stem cell pluripotency. PMID: 28057922
2. Stx4a plays a critical role in bone matrix production by osteoblasts. PMID: 27933643
3. Syntaxin-4 not only bound to laminin but also latched onto the glycosaminoglycan side chains of syndecan-1, a laminin receptor that mediates epithelial morphogenesis. Thus, temporal extracellular extrusion of syntaxin-4 emerged as a novel regulatory element for laminin-induced mammary epithelial cell behaviors. PMID: 27463539
4. Syn4 transgenic mice with high level expression of Syn4 had a significant extension of lifespan (33% increase in median) and showed increased peripheral insulin sensitivity, even at ages where controls exhibited age-related insulin resistance. PMID: 26331606
5. Non-directional stimulation with extracellular syntaxin-4 induces a dramatic morphological change in teratocarcinoma F9 cells and in several endodermal markers, both of which effects are reminiscent of the cells treated with all-trans retinoic acid. PMID: 23884628
6. Delivery of GLUT4 to the plasma membrane is mediated by formation of functional SNARE complexes containing syntaxin4, SNAP23, and VAMP2. PMID: 24469400
7. data support a mechanistic model for gelsolin's role in insulin exocytosis: gelsolin clamps unsolicited soluble N-ethylmaleimide-sensitive factor attachment receptor-regulated exocytosis through association with Syn4 which is relieved upon stimulus-induced calcium influx to activate gelsolin to facilitate insulin exocytosis PMID: 22108804
8. Syntaxin 4 activation and insulin release in the absence of the glucose stimulus, consistent with nitrosative stress and dysfunctional exocytosis PMID: 21393240
9. regulated during macrophage activation to function in membrane traffic and cytokine secretion PMID: 12546791
10. functions as the necessary t-SNARE protein responsible for correct fusion of the GLUT8-containing vesicle with the plasma membrane in the mouse blastocyst PMID: 12829803
11. female Syn4 transgenic mice exhibited an increased rate of glucose clearance during glucose tolerance tests that was repressible by the administration of tetracycline PMID: 15331531
12. Data show that Munc18c binds to monomeric syntaxin4 and the N-terminal 29 amino acids of syntaxin4 are necessary for this interaction. PMID: 16899085
13. analysis of a new underlying mechanism by which F-actin negatively regulates exocytosis via binding and blocking Syntaxin 4 accessibility PMID: 18285343
14. tyrosine phosphorylation of Munc18c induces a switch in binding specificity from syntaxin 4 to Doc2beta PMID: 18541526
15. Data show that syntaxin-4 directly associates with DOC2 in an intracellular Ca(2+)-dependent manner. PMID: 19033398

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KEGG: mmu:20909

STRING: 10090.ENSMUSP00000033075

UniGene: Mm.24867