Recombinant Mouse Translocating chain-associated membrane protein 2(Tram2)

Code CSB-CF838777MO
Product Type Transmembrane Protein
Size Pls inquiry other sizes
Uniprot No. Q924Z5
Storage Buffer Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Species Mus musculus (Mouse)
Sequence MAFRRRTKSYPLFSQEFIIHNHADIGFCLVLCVLIGLMFEVTAKTAFLFILPQYNISVPT ADSETVHYHYGPKDLVTILFYVVITIIFHAVVQEYILDKISKRLHLSKVKHSKFNESGQL LVFHLSAVAWCFYVIVTEGYLTNPRSLWEDYPHVYLSFQVKFFYLGQLAYWLHSLPELYF QKVRKEEVPRQLQYICLYLLHITGAYLLNLSRLGLILLLLQYSTEALFHMARLFHFADEN NERLFNAWAAVFGVTRLFILTLAVLTIGFGLARVENQVFDPEKGNFNTLPCRLGMLLLVC VAQAWLMWRFIHSQLRHWREYWKEQSAKRRVSAVPRPPAKLLKREPGYHENGVVKAENGT SSRTKKLKSP
Source in vitro E.coli expression system
Gene Names Tram2
Protein Names Recommended name: Translocating chain-associated membrane protein 2
Expression Region 1-370
Tag Info N-terminal 10xHis-tagged
Protein Description full length protein
Storage Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Necessary for collagen type I synthesis. May couple the activity of the ER Ca(2+) pump SERCA2B with the activity of the translocon. This coupling may increase the local Ca(2+) concentration at the site of collagen synthesis, and a high Ca(2+) concentration may be necessary for the function of molecular chaperones involved in collagen folding. Required for proper insertion of the first transmembrane helix N-terminus of TM4SF20 into the ER lumen, may act as a ceramide sensor for regulated alternative translocation (RAT).
Subcellular Location Membrane, Multi-pass membrane protein
Protein Families TRAM family
Database Links

KEGG: mmu:170829

STRING: 10090.ENSMUSP00000047992

UniGene: Mm.185680

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