Recombinant Mouse Zinc transporter 3 (Slc30a3)

1. ZnT3-/- mice showed reduced colchicine-induced dentate granule cell death. PMID: 29048371
2. the ZnT3 null state removed synaptic zinc, it rather increased free zinc in the cytosol of brain cells, which appeared to increase MMP-9 activity and BDNF levels. The present results suggest that zinc dyshomeostasis during the critical period of brain development may be a possible contributing mechanism for ASD. PMID: 27352957
3. Study showed a behavioral phenotype specifically for female ZnT3 knockout (KO) mice. Comparing results to previous studies, it appears that there may be sex-specific effects of eliminating ZnT3. Female ZnT3 KO mice exhibit abnormalities in locomotion and at skilled motor learning, but study was unable to detect spatial or fear learning deficits previously described in male ZnT3 KO mice. PMID: 28012850
4. Regarding rs11126936, the serum zinc concentration was lower in CC homozygotes (0.75 +/- 0.31 mg/L) than in A carriers (0.89 +/- 0.28 mg/L, P = .016). PMID: 25249019
5. ZnT3 null mice lack the transporter responsible for stocking synaptic vesicles, although they do have a zinc veneer, albeit diminished compared to wild-type animals. PMID: 23077720
6. Dietary or ZnT3-dependent Zn(2+) stores, and intracellular Zn(2+) release from rhodopsin recycling are suggested to be involved in light-induced retinal degeneration. PMID: 23274584
7. Fundamental changes occur in the expression of proteins and genes important in neurotransmission and are different in the absence of vesicular zinc in ZnT3-deficient knockout mice. PMID: 21871936
8. This study demonistrated that zinc transporter-3 regulate the Zinc in brain. PMID: 21911210
9. Zinc transporters of the Slc30a/ZnT and Slc39a/Zip families play crucial roles in cell functions, mediating zinc influx to and efflux from the lumen of the secretory pathway, constitutively or in a cell-specific manner. (Review) PMID: 21670538
10. Deprivation of oxygen and glucose-SD produced large FluoZin-3 increases that propagated with the event, and signals were abolished in tissues from ZnT3 knockout animals lacking synaptic Zn(2+) PMID: 20978516
11. ZnT3 is important for zinc homeostasis modulating presynaptic MAPK signaling and is required for hippocampus-dependent memory PMID: 21245308
12. The results of this study suggested that ZnT3 protein is involved in the Abeta aggregation in the cerebellum of the AbetaPP/PS1 mouse. PMID: 20164588
13. Age-dependent loss of transsynaptic Zn(2+) movement leads to cognitive loss, and since extracellular beta-amyloid is aggregated by this pool of Zn(2+), the genetic ablation of ZnT3 may represent a phenocopy for the synaptic and memory deficits of AD. PMID: 20130173
14. In hippocampal slices from zinc transporter 3 knockout mice, there was greater attenuation of GABA(A)-mediated inhibitory postsynaptic potentials during tetanic stimulation compared with slices from wild-type animals. PMID: 12535956
15. ZnT3 and zinc ions are present in a subpopulation of TH-positive, NPY-negative neurons in the rodent superior cervical ganglia. PMID: 12895501
16. ZnT3 synaptic vesicles content was reduced in AP-3-deficient neurons. PMID: 14657250
17. In transgenic mouse models of Alzheimer's disease synaptic ZnT3 activity may promote cerebral amyloid angiopathy by indirectly raising exchangeable Zn2+ concentrations in the perivascular spaces of the brain PMID: 15056725
18. Expression of zinc transporter ZnT3 in mouse choroid epithelial cells suggests that the choroid plexus plays an important role in regulation of zinc homeostasis in the brain. PMID: 15257151
19. Adrenalectomy causes reduction in vesicular zinc concentration and a downregulation of ZnT3 proteins in the hippocampal region, suggesting that ZnT3 is responsible for transport of zinc ions into a pool of synaptic vesicles in zinc-enriched terminals. PMID: 15755519
20. The barrel-like pattern detected by ZnT3 immunohistochemistry was visble for the first time at postnatal 14 day in the mice. PMID: 15982526
21. The ZNT3 protein evidently controls not only the "stainability" but also the actual mass of zinc in mossy-fiber synaptic vesicles. This work thus confirms the metal-transporting role of the ZNT3 protein in the brain. PMID: 17712179
22. the progressive increase of ZNT3 immunostaining in the temporal lobe epileptic hippocampus may relate to the increased levels of vesicular zinc ions during seizure PMID: 18406010
23. Knock-down of the ZnT-3 gene lowers insulin secretion in vitro and affects in vivo glucose metabolism after streptozotocin treatment. PMID: 19492079
24. SLC30A3 (ZnT3) oligomerization by dityrosine bonds regulates its subcellular localization and metal transport capacity PMID: 19521526

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KEGG: mmu:22784

STRING: 10090.ENSMUSP00000031037

UniGene: Mm.1396