Recombinant Oncorhynchus masou Dynamin-like 120 kDa protein, mitochondrial (opa1)

Code CSB-CF529606OEH
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Source in vitro E.coli expression system
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Product Details

Target Names
opa1
Uniprot No.
Alternative Names
opa1; Dynamin-like 120 kDa protein, mitochondrial; 120 kDa G protein expressed in motor neurons; Optic atrophy protein 1 homolog; mG120
Species
Oncorhynchus masou (Cherry salmon) (Masu salmon)
Expression Region
201-971
Target Protein Sequence
AATEAPVTATPEASDKQFKKSSDKEKVDQLQEELLRTQMKYQRMLERLEKENKDLRKVVL QKDEKGIHQRKIKKSLIDMYSEVLDILSDFDSNYNTQDHLPRVVVVGDQSAGKTSVLEMI AQARIFPRGSGEMMTRSPVKVTLSEGPHHVAMFKDSSREFDLGKEEDLAALRHEIELRMR KSVKEGQTVSPETISLSVKGPGIQRMVLVDLPGVISTVTAGMAADTKETIFSISKNYMQN PNAIILCIQDGSVDAEADRHRPGQSNGPAGERTIFVLTKVDLAEKNLASPNRIQQIVEGK LFPMKALGYFAVVTGKGSAGESIDSIKDYEEDFFQNSRLLRDGMLKAHQVTTKNLSLAVS DCFWKMVRESVEQQADAFKASRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEVISLS QVTPKHWEAILQKKLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQLPHKA LEVAWETLQEEFARFMAEYKGKDQDDIFDKLKEAVKDESIKRHKWNERAMDSLRVIQHNA LEDRSITDKPQWDAAIQFMEETLQARLKDTDSVINDMVGPDWKQRWMSWKNRSPEQHTRN ETRNELERLLKLHEDHTAYLANDEVTTVRKNLEGRGVEVDPALIKDTWHQLYRRHFLQKA LQHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLLITANTLRQQLTNTEVRRLEKN VKEVLEDFGEDNERKVHLITGRRVQLAEDLKKVREIQEKLEAFIEALHKEK
Protein Length
full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
Dynamin-related GTPase that is essential for normal mitochondrial morphology by regulating the equilibrium between mitochondrial fusion and mitochondrial fission. Binds lipid membranes enriched in negatively charged phospholipids, such as cardiolipin, and promotes membrane tubulation. The intrinsic GTPase activity is low, and is strongly increased by interaction with lipid membranes. Plays a role in remodeling cristae and the release of cytochrome c during apoptosis.; Inactive form produced by cleavage at S1 position by oma1 following stress conditions that induce loss of mitochondrial membrane potential, leading to negative regulation of mitochondrial fusion.
Subcellular Location
Mitochondrion inner membrane; Single-pass membrane protein. Mitochondrion intermembrane space. Mitochondrion membrane.
Protein Families
TRAFAC class dynamin-like GTPase superfamily, Dynamin/Fzo/YdjA family
Tissue Specificity
Strongly expressed in the brain, ovary and skeletal muscle. In the brain, expression of the mRNA was observed specifically in motor neurons, in nucleus oculomotorius, in nucleus valvulae lateralis, in the medulla oblongata and in the spinal cord.
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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