Recombinant Rat 5-hydroxytryptamine receptor 3A (Htr3a)

1. Data support a functional role for serotonergic signaling in the mesolimbic pathway on motivated behavior, and demonstrate that 5-HT3 serotonin receptors differentially modulate food consumption in a region-dependent manner. PMID: 28115218
2. This study demonstrates that AITC-induced nociception in vivo depends on TRPA1 and is decreased by the blockade of the NK1 receptor for SP, the H1 receptor for histamine and the 5-HT1A and 3 receptors for 5-HT PMID: 27904941
3. Study concludes that the serotonin 3 receptor does not play a unique role in mediating stress-induced hyperalgesia related to temporomandibular joint nociception. PMID: 25913635
4. The inhibition of I(5-HT3) by WIN55,212-2 is probably new one of peripheral analgesic mechanisms of WIN55,212-2, but the mechanism by which WIN55,212-2 inhibits I(5-HT3) warrants further investigation. PMID: 22528232
5. glucose may also be able to modulate the ability of GI vagal afferent neurons to respond to the released 5-HT, via regulation of neuronal 5-HT(3) receptors PMID: 22845622
6. Activation of 5-HT3 receptors in the posterior insular cortex is important for nausea-induced conditioned disgust reactions. Those in the anterior IC are involved in the production of conditioned taste avoidance. PMID: 23035083
7. Acute myocardial ischemia augments the Bezold-Jarisch reflex induced via activation of TRPV1 and 5-HT(3) receptors located on sensory vagal nerves in the heart. PMID: 22358093
8. Spinal 5-HT(3) receptors play an important role during development and maintenance of pain evoked long-term behaviors. PMID: 22289689
9. 5-HT3R may play a role in initiation of the nociceptive response. PMID: 21186576
10. 5-HT3 receptors in the basal forebrain exert a tonic sympathoinhibitory action that is mediated via the local release of angiotensin in the septal nuclear complex. PMID: 20817619
11. Data indicate that the hypotensive response observed after pharmacological stimulation of central 5-HT(3) receptors depends on the functional integrity of brain mu, kappa and delta opioid receptors. PMID: 21514668
12. 5-HT(3) receptor-mediated somatostatin-dependent secretoinhibitory pathway is suppressed in the water-immersion restraint stressed rats PMID: 21291881
13. results of this study suggest that 5-HT(3) receptors in the posterior ventral tegmental area of the alcohol-preferring rat may be involved in regulating ethanol self-administration PMID: 20682192
14. results suggest that 5-HT is released from serotoninergic neurons, their processes and enterochromaffin cells. The effect of 5-HT mediated by 5-HT3 receptors involves distinct neuronal and non-neuronal pathways which modulate gastric acid secretion. PMID: 20359130
15. investigated the role of central 5-HT3 receptors on the control of blood glucose in stressed and non-stressed rats in both fasted and fed states PMID: 11972287
16. To identify the interaction of amino acids in binding loop E with 5-HT3R ligands, alanine mutations of residues throughout the loop have been constructed and evaluated for alteration in binding affinity of 5 different classes of 5-HT3R ligands. PMID: 12079500
17. 5-HT3 receptor-like immunoreactivity is found in fibers sparsely distributed throughout the cerebellum; most of them are seen in the cerebellar cortex as fine varicose 5-HT3-positive axonal processes. PMID: 12084412
18. 5-HT3A-short and alpha4-nAChR expressed in interneurons. No 5-HT3B or 5-HT3A-long. 2-Aminoethyl methanethiosulphonate enhanced 5-HT3R-mediated responses. Alpha4-nAChR co-assembles with 5-HT3A to form native heteromeric 5-HT(3)R channel. PMID: 12411518
19. Twenty-six percent of dorsal root ganglia cell bodies displayed 5-HT3 receptor-like immunoreactivity. Colonic sensory neurones expressing 5-HT3 receptors also functionally express the receptors at their peripheral endings. PMID: 12411529
20. Most dorsal horn axons immunoreactive for 5-HT(3)A receptor subunits do not originate from the subtypes of primary afferent fibres that bind IB4 or contain CGRP. PMID: 12592509
21. The distribution of the energy barriers and binding sites for Ca(2+) and Na(+) showed that the binding sites are located at approximately the 13' and the -4' position in the ion channel. PMID: 12611954
22. 5-hydroxytryptamine-3 receptors occur on intrinsic sensory neurons in the rat colon, and on extrinsic sensory nerve fibers that innervate the colon. PMID: 12617944
23. Results indicate that spinal 5-HT3 receptors are involved in the modulation of pain sensitivity: receptor activation inhibits nociceptive reactions, while receptor blockade potentiates the nociceptive response via modulation of GABAergic interneurons. PMID: 12937671
24. Coexistence of 5-HT3A and CB1 cannabinoid receptor transcripts in interneurons of cortex, hippocampal formation and amygdala suggest possible interactions between cannabinoid and serotonergic systems involved in cognition, memory and emotion. PMID: 14648680
25. 5HT3 receptor mediated descending facilitation remains unaltered after tissue inflammation. PMID: 15135935
26. These data are consistent with the hypothesis that vagal inputs, including non-myelinated cardiopulmonary inputs to the NTS, utilize a 5-HT-containing pathway which activates 5-HT3 receptors. PMID: 15905216
27. The results suggest that 5-HT(3) receptors are present principally on terminals of excitatory axons, and at least some of these originate from dorsal horn interneurons. PMID: 15975728
28. Thus, the great majority of neurons expressing 5-HT(3A)R protein appear to constitute a previously unrecognized subpopulation of GABAergic interneurons in the BLC. PMID: 17150309
29. stress-induced sensitization of visceral nociception is independent of 5-HT3R activation on vagal afferents PMID: 17161536
30. More than half of all ganglion neurons that project to the masseter or temporalis muscle express the 5-HT3 receptor. PMID: 17467903
31. 5-HT(3) receptors possess a role of dual regulation on electrolyte secretion in rat distal colon, the neural stimulatory effect of 5-HT(3) receptor in myenteric plexus and the inhibitory effect of 5-HT(3) receptor in submucosal plexus. PMID: 18313044
32. Increased 5-hydroxytryptamine in colonic mucosa mediates post-inflammatory visceral hypersensitivity through activation of the 5-hydroxytryptamine 3 receptor. PMID: 18357529
33. Loop B has a major role in maintaining the structure of the region by a series of noncovalent interactions that are easily disrupted by amino acid substitutions. PMID: 18931259
34. This study provides direct evidence for the involvement of serotonin 5-HT3 receptors in the effects of 5-HT on pancreatic vagal afferent discharge PMID: 19026634
35. We suggest that regardless of whether or not they cause edema, IgE-mediated mast cell degranulation and consequent 5-HT(3) signaling are involved in the process that triggers avoidance to the source of the allergen in allergic rats. PMID: 19077442
36. These observations indicate that the cardiorespiratory changes induced by intra-arterial injection of venom are carried by afferents in addition to somatic nerves, involving mainly VR1 receptors and partially by 5-HT(3) receptors. PMID: 19154775
37. These results demonstrate that hypoxia recruits a 5-HT pathway to cardiac vagal neurons that activates 5-HT3 receptors on CVNs to maintain parasympathetic cardiac activity during hypoxia. PMID: 19247214
38. Results demonstrate a time-dependent vagal afferent modulation of chronic allergen-sensitized visceral hyperalgesia, which may involve a 5-HT(3)R pathway. PMID: 19558425

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KEGG: rno:79246

STRING: 10116.ENSRNOP00000008965

UniGene: Rn.55109