Recombinant Rat Leucine-rich repeat transmembrane protein FLRT3(Flrt3)

Code CSB-CF008731RA
Product Type Transmembrane Protein
Size Pls inquiry other sizes
Uniprot No. B1H234
Storage Buffer Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Species Rattus norvegicus (Rat)
Source in vitro E.coli expression system
Gene Names Flrt3
Protein Names Recommended name: Leucine-rich repeat transmembrane protein FLRT3 Alternative name(s): Fibronectin-like domain-containing leucine-rich transmembrane protein 3
Expression Region 29-649
Tag Info N-terminal 10xHis-tagged
Protein Description Full Length of Mature Protein
Storage Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Functions in cell-cell adhesion, cell migration and axon guidance, exerting an attractive or repulsive role depending on its interaction partners. Plays a role in the spatial organization of brain neurons. Plays a role in vascular development in the retina (By similarity). Plays a role in cell-cell adhesion via its interaction with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells (By similarity). Interaction with the intracellular domain of ROBO1 mediates axon attraction towards cells expressing NTN1. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5B, and possibly also other UNC-5 family members (By similarity). Promotes neurite outgrowth (in vitro) (By similarity). Mediates cell-cell contacts that promote an increase both in neurite number and in neurite length
Subcellular Location Cell membrane, Single-pass membrane protein, Cell junction, synapse, synaptosome, Cell junction, synapse, postsynaptic cell membrane, postsynaptic density, Cell projection, dendrite, Cell junction, synapse, Cell junction, synapse, presynaptic cell membrane, Cell projection, axon, Cytoplasmic vesicle, Endoplasmic reticulum membrane, Cell junction, focal adhesion, Secreted, Cell projection, axon
Tissue Specificity Detected in brain (at protein level) (PubMed:22405201). Detected in brain neurons, especially in basal ganglia, hippocampus dentate gyrus and CA3 region, cerebellum and in olfactory bulb (PubMed:14706654, PubMed:15485775).
Database Links

KEGG: rno:366205

STRING: 10116.ENSRNOP00000006454

UniGene: Rn.220263

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