Membrane metallo-endopeptidase-like 1
Short name= NEPII
Short name= NEP2
Short name= NL2
Cleaved into the following chain:
1. Membrane metallo-en
full length protein
Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Metalloprotease involved in sperm function, possibly by modulating the processes of fertilization and early embryonic development. Degrades a broad variety of small peptides with a preference for peptides shorter than 3 kDa containing neutral bulky aliphatic or aromatic amino acid residues. Shares the same substrate specificity with MME and cleaves peptides at the same amide bond (By similarity).
Membrane, Single-pass type II membrane protein, Secreted
Peptidase M13 family
Specifically expressed in testis and central nervous system (CNS) (at protein level). Restricted to developing and differentiating fields of the CNS. The soluble form is expressed in round spermatides.