Recombinant Rat Myelin proteolipid protein (Plp1)

Code CSB-CF018202RA
Size Pls inquire
Source in vitro E.coli expression system
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Product Details

Target Names
Plp1
Uniprot No.
Alternative Names
Plp1; Plp; Myelin proteolipid protein; PLP; Lipophilin
Species
Rattus norvegicus (Rat)
Expression Region
2-277
Target Protein Sequence
GLLECCARCLVGAPFASLVATGLCFFGVALFCGCGHEALTGTEKLIETYFSKNYQDYEYL INVIHAFQYVIYGTASFFFLYGALLLAEGFYTTGAVRQIFGDYKTTICGKGLSATVTGGQ KGRGSRGQHQAHSLERVCHCLGKWLGHPDKFVGITYALTVVWLLVFACSAVPVYIYFNTW TTCQSIAFPSKTSASIGSLCADARMYGVLPWNAFPGKVCGSNLLSICKTAEFQMTFHLFI AAFVGAAATLVSLLTFMIAATYNFAVLKLMGRGTKF
Protein Length
Full Length of Mature Protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin.
Gene References into Functions
  1. PLP and DM-20 mRNA expression is restricted to oligodendrocyte-lineage cells PMID: 26563642
  2. Protein levels of PLP were significantly greater in orbital frontal cortex (OFC) but not dorsal striatum (dSTR) of females as compared to males, suggesting that myelination is increased in OFC but similar in dSTR of females as compared to males PMID: 26002313
  3. Perinatal methylmercury exposure reduces the expression of Plp1 and Cnp splice variants in cerebellum of rat pups. PMID: 25936639
  4. PLP localization in the cell membrane is altered in myelination-inhibiting fibronectin substrates. PMID: 25003183
  5. PLP transport to the myelin membrane proceeds via a transcytotic mechanism mediated by sulfatide with a conformational alteration and transient partitioning of PLP into distinct membrane microdomains involved in biosynthetic and transcytotic transport PMID: 25368380
  6. Differences in myelin and disparate distributions of myelin protein markers in comparison to wild-type controls are observed in PLP1 transgenic rats. PMID: 21784154
  7. Mutation in the myelin proteolipid protein gene alters BK and SK channel function in the caudal medulla. PMID: 19808102
  8. Proteolipid protein gene modulates viability and phenotype of neurons; PLP-specific products contributed to decreased neuron survival. PMID: 11880506
  9. We conclude that an ESE in exon3B regulates PLP 5' donor site selection and that ASF/SF2 protein participates in the regulation of PLP alternative splicing in oligodendrocytes. PMID: 16288477

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Involvement in disease
Defects in Plp1 are the causee of the dysmyelinating disease MD.
Subcellular Location
Cell membrane; Multi-pass membrane protein. Myelin membrane.
Protein Families
Myelin proteolipid protein family
Database Links
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