Recombinant Rat Prostaglandin E2 receptor EP1 subtype (Ptger1)

Code CSB-CF018970RA
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Source in vitro E.coli expression system
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Product Details

Target Names
Ptger1
Uniprot No.
Alternative Names
Ptger1; Prostaglandin E2 receptor EP1 subtype; PGE receptor EP1 subtype; PGE2 receptor EP1 subtype; Prostanoid EP1 receptor
Species
Rattus norvegicus (Rat)
Expression Region
1-405
Target Protein Sequence
MSPYGLNLSLVDEATTCVTPRVPNTSVVLPTGGNGTSPALPIFSMTLGAVSNVLALALLA QVAGRLRRRRSTATFLLFVASLLAIDLAGHVIPGALVLRLYTAGRAPAGGACHFLGGCMV FFGLCPLLLGCGMAVERCVGVTQPLIHAARVSVARARLALALLAAMALAVALLPLVHVGH YELQYPGTWCFISLGPPGGWRQALLAGLFAGLGLAALLAALVCNTLSGLALLRARWRRRR SRRFRENAGPDDRRRWGSRGLRLASASSASSITSTTAALRSSRGGGSARRVHAHDVEMVG QLVGIMVVSCICWSPLLVLVVLAIGGWNSNSLQRPLFLAVRLASWNQILDPWVYILLRQA MLRQLLRLLPLRVSAKGGPTELSLTKSAWEASSLRSSRHSGFSHL
Protein Length
Full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function. Implicated the smooth muscle contractile response to PGE2 in various tissues. Isoform 1 and isoform 2 have identical ligand binding properties, but isoform 2 lacks coupling to calcium mobilization and may therefore attenuate the action of PGE2 on tissues.
Gene References into Functions
  1. Our study identifies the EP1 signaling pathway as an important link between neuroinflammation and MMP-mediated BBB breakdown in ischemic stroke. PMID: 26648273
  2. A transient interaction between COX-2 and EP1 constitutes a feedback loop whereby an increase in COX-2 expression elevates EP1. PMID: 24614038
  3. Results indicate that EP1 receptor activation during seizures, through a protein kinase C pathway, increases probability of kainic acid induced status epilepticus, and independently promotes hippocampal neurodegeneration and a broad inflammatory response PMID: 24952362
  4. EP1 deletion exacerbates neuro-behavioral impairments following intracerebral hemorrhage, potentially by slowing down/impairing microglial phagocytosis. PMID: 23824501
  5. PGE2 appears to act both as a primary mediator of antigen-induced airway contraction via the EP4 receptor and as a downstream modulator of serotonin-induced bronchoconstriction via the EP1 receptor PMID: 23220160
  6. Results suggest that prostanoid EP(1) receptors are involved in positive regulation of the beating rate. PMID: 22984630
  7. The blockade of EP1 receptor in the ventrolateral periaqueductal grey leads to antinociception in neuropathic pain conditions, despite its down-regulation. PMID: 22023852
  8. In the trigeminal-vascular system (TVS) we found highest expression of EP(1) and EP(2) protein in the trigeminal nucleus caudalis. PMID: 22061836
  9. EP1 receptors were expressed in forebrain neurons & were induced in endothelial cells after hypoxic-ischemic injury in the neonatal rat. Its inhibition by SC-51089 reduced the injury. PMID: 21939736
  10. An EP1 receptor antagonist improves pain-related behavior in the rat model and might be a potential agent to improve pain-related behavior in patients with lumbar disc herniation. PMID: 21270690
  11. These results suggest that PGE(2)-EP1 signaling has crucial roles in suppression of myoelectrical activity of gastric smooth muscles and inhibition of gastric emptying PMID: 20798358
  12. After partial sciatic nerve ligation PGE2 is one of the possible prostaglandins[PGs] overproduced in injured nerve and PG overproduction is involved in the up-regulation of EP receptors in injured nerve PMID: 14552899
  13. Prostaglandin E receptor EP1 subtype has a role in the development of renal injury in hypertensive rats. PMID: 14670979
  14. Spinal PGE2 activates EP1 receptors on central terminals of primary afferents, subsequently increasing in [Ca2+]i in the spinal dorsal horn, which mediates spinal PGE2-induced nociceptive transmission. PMID: 15126118
  15. PGE(2) increases Fn and promoted bone formation in rat osteoblasts via the EP(1)/phospholipase C/PKCalpha/c-Src signaling pathway PMID: 15833739
  16. Results indicate that the EP1 prostanoid receptor is expressed in specific brain neuronal populations, which possibly determine the region-specific response to prostaglandin E2. PMID: 16280600
  17. EP1 receptor level increase in sensory neurones, and macrophage infiltration, appears to precede increased Cox-2 expression by macrophages in nerve injury PMID: 16393343
  18. In growth plate chondrocytes, cyclooxygenase-2 is responsible for PGE2 release, which stimulates cell proliferation via the EP1 receptor. PMID: 16646980
  19. Results suggest that loxoprofen or EP1 prostanoid receptor antagonists inhibit the inflammation-related neuronal activity in the bladder. PMID: 16707842
  20. These data provide evidence of the role of prostaglandins in neuropathic pain, and suggest that not only infiltrating macrophages but also Schwann cells may be involved in the modulation of these mediators in response to nerve injury. PMID: 17110143
  21. role of E prostanoid receptors EP1, EP2, & EP3 and F prostanoid receptors in enhancing the growth-stimulatory effect of epidermal growth factor in cultured hepatocytes PMID: 17567965
  22. support the possibility of targeting the EP1 receptor for antihypertensive therapy PMID: 17710229
  23. Examine the role of prostaglandin E and thromboxane-prostanoid receptors in the response to prostaglandin E2 in the aorta of Wistar Kyoto rats and spontaneously hypertensive rats. PMID: 18093985

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Subcellular Location
Cell membrane; Multi-pass membrane protein.
Protein Families
G-protein coupled receptor 1 family
Tissue Specificity
Highly abundant in kidney and lung. Found in a lesser extent in spleen, colon, and thymus. Also expressed in uterine myometrium and endometrium.
Database Links
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