Recombinant Varicella-zoster virus Envelope glycoprotein I(gI)

Code CSB-CF357613VAP
Product Type Transmembrane Protein
Size Pls inquiry other sizes
Uniprot No. P09258
Storage Buffer Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Species Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3)
Sequence TNALIFKGDHVSLQVNSSLTSILIPMQNDNYTEIKGQLVFIGEQLPTGTNYSGTLELLYA DTVAFCFRSVQVIRYDGCPRIRTSAFISCRYKHSWHYGNSTDRISTEPDAGVMLKITKPG INDAGVYVLLVRLDHSRSTDGFILGVNVYTAGSHHNIHGVIYTSPSLQNGYSTRALFQQA RLCDLPATPKGSGTSLFQHMLDLRAGKSLEDNPWLHEDVVTTETKSVVKEGIENHVYPTD MSTLPEKSLNDPPENLLIIIPIVASVMILTAMVIVIVISVKRRRIKKHPIYRPNTKTRRG IQNATPESDVMLEAAIAQLATIREESPPHSVVNPFVK
Source in vitro E.coli expression system
Gene Names gI
Protein Names Recommended name: Envelope glycoprotein I Short name= gI Alternative name(s): Glycoprotein IV Short name= GPIV
Expression Region 18-354
Tag Info N-terminal 10xHis-tagged
Protein Description Full Length of Mature Protein
Storage Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function In epithelial cells, the heterodimer gE/gI is required for the cell-to-cell spread of the virus, by sorting nascent virions to cell junctions. Once the virus reaches the cell junctions, virus particles can spread to adjacent cells extremely rapidly through interactions with cellular receptors that accumulate at these junctions. Implicated in basolateral spread in polarized cells. In neuronal cells, gE/gI is essential for the anterograde spread of the infection throughout the host nervous system. Together with US9, the heterodimer gE/gI is involved in the sorting and transport of viral structural components toward axon tips (By similarity).
Subcellular Location Virion membrane, Single-pass membrane protein, Host cell membrane, Single-pass type I membrane protein, Host cell junction, Host Golgi apparatus membrane, Single-pass type I membrane protein
Protein Families Alphaherpesvirinae glycoprotein I family
Database Links

KEGG: vg:1487689

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