Recombinant Xenopus laevis Vang-like protein 2-A(vangl2-a)

Code CSB-CF849550XBE
Product Type Transmembrane Protein
Size Pls inquiry other sizes
Uniprot No. Q90X64
Storage Buffer Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Species Xenopus laevis (African clawed frog)
Sequence MDNDSQYSGYSYKSGHSRSSRKHRDRRERHRSKSREGSRGDKSVTIQAPGEPLLDNESTR GEDRDDNWGETTTVVTGTSEHSISHDDITRITKDMEDSAKLDCSRHLGVVIGGALALLSF LTPIAFMLLPQILWREDLEQCGTACEGLFISVAFKLLILLLGSWALFFRRPKAFFPRVFV FRALLMVLVFLLVVSYWLFYGVRILESRDKNYQGIVQYAVSLVDALLFVHYLAVVLLELR QLQPQFTIKVVRSTDGASRFYNIGHLSIQRVAVWILENYYHDFPVYNPALLNLPKSILSK KMSGFKVYSLGEENTTNNSTGQSRAVIAAAARRRDNSHNEYYYEEAEHERRVRKRKARLV VAVEEAFTHIKRLQDEDQKNPREIMDPREAAQAIFASMARAMQKYLRTTKQQPYHTMESI LHHLEFCITHDMTPKAFLERYLGPGPTIQYHKDRWLAKQWTLVSEEPVTNGLKDGVVFVL KRQDFSLVVSTKKIPFFKLSEEFVDPKSHKFVMRLQSETSV
Source in vitro E.coli expression system
Gene Names vangl2-a
Protein Names Recommended name: Vang-like protein 2-A Alternative name(s): Protein strabismus-A Van Gogh-like protein 2-A Xstrabismus-A Short name= Xstbm-A
Expression Region 1-521
Tag Info N-terminal 10xHis-tagged
Protein Description full length protein
Storage Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Has a role in non-canonical Wnt/planar cell polarity (PCP) signaling; can recruit dvl/dsh and prickle from the cytoplasm to the plasma membrane. Acts in a PCP complex to regulate the polarized assembly of fibronectrin on the surface of the mesoderm during gastrulation. Regulates convergent extension cell movements in both dorsal mesoderm and neural tissue during gastrulation, without affecting cell fate. Regulates neural fold closure during neurulation
Subcellular Location Cell membrane, Multi-pass membrane protein
Protein Families Vang family
Tissue Specificity During gastrulation, broadly expressed throughout the marginal zone and animal cap region. From the neurula stages, expression becomes concentrated in neural tissues, in the neural plate and neural tube.
Database Links

KEGG: xla:398271

UniGene: Xl.10610

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