Never Stay Up All Night

On 2 Oct. 2017, the Nobel Prize in Physiology or Medicine 2017 was awarded to three scientists for their discoveries of molecular mechanisms controlling the circadian rhythm.

Maybe some of us know all living organisms have an internal, biological clock. Jeffrey C. Hall, Michael Rosbash and Michael W. Young have explained how plants, animals and humans adapt their biological rhythm so that it is synchronized with the Earth's revolutions.

I think most of us are familiar with some following phenomena.

The sunflower has began to turn east before sunrise.

Human still can not resist the thick sleepiness on a bright night.

Mimosa leaves are still open and closed on the day and night regularly although the mimosa has been covered with a hood.

Next, let us get to know how the molecular mechanisms control the circadian rhythm.

Those three scientists-Jeffrey C. Hall, Michael Rosbash and Michael W. Young used fruit flies as biological models and isolated a period gene, then went on to discover that PER, the protein encoded by period gene, accumulated during the night and was degraded during the day. Thus, PER protein levels oscillate over a 24-hour cycle, in synchrony with the circadian rhythm, which control the circadian rhythm.

That is to say, our internal biological clock tells us when to be sleepy and when to be alert. Because our bodies are like a well-ordered factory, and the activities of different organs in our bodies are like highly coordinated production lines. But if our biological clock has been disrupted, the factory will be in a mess. That’s also why we should have a jet lag after a long journey.

For a short-term disorder of body clock, if we want to recover, then the brain needs 1 week, but intestines and stomach need at least 2 weeks. For a long-term disorder of body clock, it will be even worse, because it could cause a range of diseases, such as obesity, diabetes, metabolic syndrome, sleep disorders, depression, and even cancer.

Especially the risk of developing various diseases will increase a lot if staying up late in the night.

In short, the laureates who often stay up late tell us that never stay up all night, or you will become ugly and old easily.

Since the seminal discoveries by the three laureates, circadian biology has developed into a vast and highly dynamic research field, with implications for our health and wellbeing. Meanwhile, Cusabio aims to offer its own contribution to the development of human health, thus all researchers could get samples of a wide range of quality antibodies related to circadian rhythms from Cusabio now!

For example, the PER3 antibody CSB-PA017788LA01HU, which is a transcription activator to form the core components of circadian rhythms, please refer to the following validation information of Cusabio PER3 antibody.

Western Blot
Positive WB detected in:Hela whole cell lysate,Mouse skeletal muscle tissue
All lanes:PER3 antibody at 4ug/ml
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 132,133 KDa
Observed band size: 132 KDa

Immunofluorescent analysis of Hela cells using CSB-PA017788LA01HU at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA017788LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA017788LA01HU at dilution of 1:100

Besides, Cusabio has many more quality antibodies related to circadian rhythms, such as CLOCK Antibody, TP53 Antibody, HDAC1 Antibody, STAT5B Antibody, MCM3 Antibody, so please enter target names or Cusabio product codes to search your interested antibodies.

Product Name Code Reactivity Application
ABCB8 Antibody CSB-PA868325ESR1HU Human, Mouse ELISA, WB, IHC
ABCB8 Antibody CSB-PA868325ESR2HU Human ELISA, IHC
ABHD5 Antibody CSB-PA819884ESR1HU Human ELISA, IHC
ABHD5 Antibody CSB-PA819884HA01HU Human ELISA, IF
ACAA1 Antibody CSB-PA001117LA01HU Human ELISA, IHC
ACAA1 Antibody CSB-PA001117ESR1HU Human, Mouse ELISA, WB
ACAA1 Antibody CSB-PA001117ESR2HU Human ELISA, IHC
ACAD9 Antibody CSB-PA887999ESR1HU Human ELISA, WB, IHC
ACAD9 Antibody CSB-PA887999EA01HU Human, Mouse ELISA, WB, IHC
ACADM Antibody CSB-PA001126LA01HU Human ELISA, IHC
ACADM Antibody CSB-PA001126ESR2HU Human ELISA, IHC


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