Scientists have discovered the secret about phosphoglucomutase


View:282 Time:2013-09-27


Phosphoglucomutase is an accelerator that transfers a phosphate cluster on an ?-D-glucose chemical compound from the 1 to the 6 position within the forward direction or the 6 to the 1 position within the reverse direction.

After polysaccharide phosphorylase catalyzes the phosphorolytic cleavage of a glucosyl residue from the polysaccharide chemical compound, the freed aldohexose encompasses a phosphate cluster on its 1-carbon. This aldohexose 1-phosphate molecule isnt itself a helpful metabolic intermediate, however phosphoglucomutase catalyzes the conversion of this aldohexose 1-phosphate to aldohexose 6-phosphate (see below for the mechanism of this reaction).

Glucose 6-phosphate’s metabolic fate depends on the wants of the cell at the time its generated. If the cell is low on energy, then aldohexose 6-phosphate can travel down the glycolytic pathway, eventually yielding 2 molecules of ATP. If the cell is in want of synthesis intermediates, aldohexose 6-phosphate can enter the monosaccharose phosphate pathway, wherever itll bear a series of reactions to yield riboses and or NADPH, betting on cellular conditions.

If this reaction is happening within the liver, the accelerator aldohexose 6-phosphatase can even turn the conversion of aldohexose 6-phosphate to aldohexose, which might leave the liver to be used in different cells. Muscle cells, however, lack aldohexose 6-phosphatase, in order that they cannot share their polysaccharide stores with the remainder of the body.

Human muscle contains 2 phosphoglucomutases with nearly identical chemical action properties, PGM I and PGM II.  One or the opposite of those forms is missing in some humans congenitally.

PGM deficiency is a particularly rare condition that doesnt have a group of well-characterized physiological symptoms. This condition will be detected by AN in vitro study of anaerobic metabolic process that reveals a block within the pathway toward carboxylic acid production when aldohexose 1-phosphate however before aldohexose 6-phosphate.

 
About news

Newsletters

Get all the latest information on Events, Sales and Offers. Sign up for newsletter today.

Copyright © 2007-2018 www.cusabio.com CUSABIO TECHNOLOGY LLC All Rights Reserved.

Wait!

Join the 25,000 subscribers to get research hotpots, technical tips, latest information on events, sales and offers.

Sign up now!

We don't deal in spam.