The important biological function of heat shock protein

View:310 Time:2013-09-29

Heat shock protein from bacteria to mammals in the presence of a wide class of thermal response proteins. When organisms when exposed to high temperatures, it will stimulate synthesis of this protein by the heat to protect the organism itself . Many heat shock proteins chaperone activity. In accordance with the size of the protein , heat shock protein is divided into five categories, namely, HSP100, HSP90, HSP70, HSP60 and the small heat shock protein small Heat Shock Proteins (sHSPs) (Kyeong et al., 1998).

Many small heat shock protein gene expression generally does not significantly small heat shock protein expression is generally when the cells are external stimuli, such as heat stimulation. It has been found, in addition to thermal stimulation in addition there are many physical, chemical stimuli can activate the small heat shock protein expression, such as ultraviolet rays, mechanical damage, acids, oxidizing agents and so on. Visible, small heat shock proteins is important to resist the adverse external stimuli substances. When the whole organism, tissue, cells from the life dramatically within a temperature range from low towards high temperatures , can significantly reduce the number of protein synthesis. For example Drosophila larvae or cultured cells moved from 28 ? 35 ?, the majority of protein synthesis almost stopped; the contrary , the shock protein synthesis but instead is promoted. The promoting effect mainly in the synthesis of messenger RNA ( transcription ) phase produced. The same phenomenon is also found in mammalian cultured cells, protozoa, plant tissue and bacteria. Also observed, other than the treatment of shock similar phenomenon also occurs . The physiological significance of this phenomenon is not clear, but presumably the biological relationship between temperature adaptation phenomenon.

HSP in the biosphere is an important feature in the evolution of their highly conserved. For example. From E. coli, yeast, Drosophila and human 70kD molecular weight separation of the hsp elisa kit, if they are full amino acid sequence analysis can be found that they have more than 80% similarity. HSP in evolutionary highly conserved , indicating that they have important physiological functions prevalent. However, research in this area, so far very insufficient.

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