The biological mechanisms regulating for membrane protein


View:298 Time:2013-09-29


Biofilm contains proteins called membrane protein, is the main bearer of biofilm function. According to the difficulty of separating proteins in the membrane distribution and location of membrane proteins can be divided into three basic categories: extrinsic membrane protein also known as peripheral membrane protein, known as intrinsic membrane protein or integral membrane protein and lipid -anchored protein.

Extrinsic membrane protein located in the inner and outer surface of the membrane, membrane protein accounts for 20 % to 30%, the main inner surface, a water-soluble protein , which by ionic bonds , hydrogen bonds with the polar head membrane lipid molecules combined, or by the interaction of proteins with intrinsic indirectly bound to the membrane.

Intrinsic membrane protein about 70% to 80 %, which is amphipathic molecules that can be embedded in different levels in the lipid bilayer . Some throughout the lipid bilayer, both ends of the inner and outer exposed surface of the film, this type of membrane protein known transmembrane proteins. Inner membrane protein exposed portion of the outer membrane with more polar amino acid, is hydrophilic, and a hydrophilic head adjacent phospholipid molecules; embedded within the lipid bilayer membrane protein by a number of non- polar amino acids, and lipid end of the hydrophobic substance with each other, so very tightly bound to the membrane.

Membrane protein function is multifaceted. Some membrane proteins can be used as "carrier " and the material transport out of the cell. Some membrane proteins are hormones or other chemicals specific receptors, such as thyroid cells to receive from the pituitary thyrotropin receptor. Membrane surface and various enzymes, the specific chemical reaction can be carried out on the film, such as the endoplasmic reticulum can catalyze the synthesis of phospholipids. Cell identification function also depends on the membrane surface proteins. These proteins are often surface antigen. Surface antigen and antibody specific binding energy, such as human cells have a protein antigen HLA, is very much a variation of a dimer.

 
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