The lysophospholipid receptor group are members of the G protein-coupled receptor family of integral membrane proteins that area unit vital for macromolecule communication. In humans, there are eight LPL receptors, each encoded by a separate sequence. These lysophospholipid receptor sequences also are generally stated as an acronym for epithelial tissue differentiation gene.
Lysophospholipid receptors are sometimes the results of phospholipase A-type protein activity on regular phospholipids like phosphatidylcholine or phosphatidic acid, although they will even be generated by the chemical change of glycerophospholipids or the phosphorylation of monoacylglycerols. Some lysophospholipid receptors serve vital communication functions like lysophosphatidic acid.
Lysophospholipid receptor ligands bind to and activate their cognate receptors set within the cytomembrane. Betting on that matter, receptor, and cell kind is concerned, the activated receptor will have a spread of effects on the cell. These embody primary effects of inhibition of adenylyl cyclase and unleash of atomic number 20 from the endoplasmic reticulum, also as secondary effects of preventing programmed cell death and increasing cell proliferation.
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