N1-methylnicotinamide small molecule can prevent high-fat diet-induced metabolic complications


In the latest issue of Nature Medicine, Israeli researchers have discovered a new pathway of vitamin B3, involved in the regulation of liver metabolism. This is called N1-methylnicotinamide small molecule can prevent high-fat diet-induced metabolic complications.

Nicotinamide adenine dinucleotide (NAD +), is a metabolite of vitamin B3. It is the food is converted to cell components in the central metabolism products. Similar to resveratrol found in red wine, NAD + can increase the protein sirtuin 1 (Sirt1) role, and we all know there are many benefits to health Sirt1. Effect of NAD + metabolism has spawned a variety of new to improve metabolic health and anti-aging dietary supplements. Although these results are not yet proven in humans, recent studies have shown that increased levels of tissue NAD + can improve the health of mice fed high-fat diet and reduce metabolic complications.

Liver plays a central role in all metabolic processes, including break down fat to produce energy. Because many different proteins are involved in NAD + metabolism, the researchers speculated that it might have an unknown pathway of vitamin B3, direct regulation of liver metabolism. To test this hypothesis, the researchers conducted a variety of experiments to detect these proteins. The results of the test indicate, nicotinamide N-methyltransfersase (NNMT), a "clear" an enzyme that helps the body excrete excess vitamin B3, to play a more prominent role in metabolism. Evidence NNMT also involved in the regulation of liver metabolism. N1-methylnicotinamide NNMT catalysed by nicotinamide methylated product, can increase protein levels Sirt1 and promote metabolism. In subsequent experiments, the researchers also found that, NNMT and Sirt1 levels, the mice healthy metabolism index was positively correlated association. While low cholesterol and triglyceride levels were also found in the human liver has a high level of NNMT and Sirt1.

Since N1-methylnicotinamide is a small molecule that can be directly fed mice. So the researchers fed mice to find out whether it can prevent high-fat diet-induced metabolic complications. As predicted, N1-methylnicotinamide increase liver Sirt1 protein, inhibiting the synthesis of triglycerides and cholesterol, protects the liver health - as compared with the control group, fewer inflammatory markers, less liver fat and low cholesterol levels.

This study identified a new regulation of liver metabolism of vitamin B3 path, this discovery will solve the obesity, type 2 diabetes and related metabolic drug therapy development of disease provides a new idea.
 
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