WAY-316606 will treat hair loss?


A few months ago, a new drug for hair loss made lots of headlines. The name is WAY-316606. It is said this drug can cure hair loss. Is that true?

Let's go and check the research.

Since the two FDA-approved drugs for hair loss, minoxidil and finasteride, have side effects, Dr. Nathan Hawkshaw from the Centre for Dermatology Research at the University of Manchester and his co-workers devoted to developing new ways to solve the issue of MAA (male androgenetic alopecia).

According to the research of Dr. Nathan, WAY-316606 was found to significantly increase hair shaft production, even as early as two days following treatment:


In addition, a team of researchers from Nanyang Technological University, Singapore, aimed to find novel approaches to enhance hair growth and therefore treat MAA. To achieve this, the team used the hair growth-stimulatory compound Cyclosporine A (CsA) to identify druggable targets.

CsA, a fungal metabolite commonly used as an immunosuppressant, is one of the few known drugs that can cause excessive hair growth. Its hair growth-stimulatory effects depend on its T cell-inhibitory activity.

As an immunosuppressant, CsA was first used to suppress transplant rejection. Now, it is also used in many other diseases, such as rheumatoid arthritis, psoriasis, Crohn's disease, and nephrotic syndrome. However, this drug has side effects, including increased hair growth.

Nanyang Technological University researchers isolated human hair follicles, treated them with CsA, and analyzed their gene expression. They found that among many other differentially regulated genes, SFRP1 showed the largest decrease. In other words, CsA reduced SFRP1 expression in human hair follicles.

SFRP1 is a member of the SFRP family that act as soluble modulators of Wnt signaling. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity).

Studies have suggested that SFRP1 functions as an inhibitor of canonical Wnt signaling and inhibits the development and growth of many tissues such as hair follicles.

In contrast, when the researchers treated human hair follicles with WAY-316606, a specific and reportedly well-tolerated antagonist of SFRP1, it inhibited SFRP1 activity, stimulated Wnt signaling, and promoted events in favor of human hair growth.


To conclude, the results revealed a novel mechanism by which CsA promotes human hair growth. In this mechanism, Wnt signaling is a target of CsA. Furthermore, inhibiting SFRP1 through the compound WAY-316606 could be an approach to facilitate Wnt signaling and promote hair growth. This approach would have applications for treating human hair loss diseases such as MAA.

So will WAY-316606 treat hair loss?
The answer is “Not quite yet”.
“The study findings are interesting but at present the investigation is at a very early experimental stage. At present, we do not know whether the proposed treatment will work in patients with hair loss or whether a suitable treatment formulation can be developed.” Said Dr Susan Holmes from British Association of Dermatologists.

It seems there is still a long way to go before the drug is approved.
A very frustrating result!

We still need to bounce back from the depression and do something before more effective drugs come.


Here is a list of common causes of hair loss. Maybe you can find something ignored.
1, Hormonal imbalance
Hormones are special chemicals created in the endocrine glands. They are the messengers traveling in your bloodstream to tissues or organs, telling the organs what to do and when to do it.
Even hormonal imbalances can cause side effects throughout the body. Hair loss is one of them.

2, Autoimmune diseases
Autoimmune diseases are diseases in which the body's immune system attacks healthy cells.
Generally, the immune system can tell the difference between foreign cells and your own cells.
However, if you have an autoimmune disease, the immune system mistakes part of your body, for example, your joints or skin, as foreign. It releases proteins called autoantibodies to attack healthy cells.
Some common autoimmune diseases include Type 1 diabetes, Multiple sclerosis, Systemic lupus erythematosus, etc.
Some of these diseases also lead to hair loss.

3, Hypothyroidism (Low Thyroid Level)
Hypothyroidism is a condition in which your thyroid gland doesn't produce enough of certain important hormones.
It is prevalent in older women.
The major symptoms include fatigue, cold sensitivity, constipation, dry skin, etc. Hair loss is also one of the symptoms.

4, Iron deficiency
Iron is a mineral that plays a vital role in health and well-being. Without it, many bodily functions would malfunction. Iron carries oxygen from the lungs and transports it throughout the body.
Fatigue, pale skin, shortness of breath, hair loss and so on are the most common symptoms.

5, Vitamin B deficiency
Similar to iron deficiency, vitamin B deficiency may lead to a reduction in healthy red blood cells. The symptoms include fatigue, breathlessness, numbness, hair loss, etc.

6, Protein deficiency
Protein deficiency is when your intake is unable to meet your body’s requirements. Protein deficiency often leaves its mark on the skin, hair and nails, which are largely made of protein.

7, Excess vitamin A
Vitamin A is important for eye health in children and adults. However, you may have hypervitaminosis A when the intake of vitamin A is too much in your body.
The symptoms of drowsiness, irritability, abdominal pain and so on will come. And hair loss is also included.

8, Stress
As we all know, stress usually brings hair loss, but why? Basically, it was because stress can raise androgen levels, which in turn can cause hair loss.

9, Dramatic weight loss
Sudden weight loss usually comes with an endocrine disorder and nutritional deficiency which usually start with hair.

10, Tight hair styles
Some hair styles put your hair under constant strain or tension can cause your hair to fall out. So you should choose your daily hairstyles very carefully.

11, Hereditary
The hereditary factor is slightly more dominant on the woman's side, but research suggests that men who have a bald father are more likely to develop male pattern baldness than those who don't.

12, Aging
Aging, the last thing we would like to mention, is also a big factor causing hair loss, especially when you are going through or about to enter the menopause.

Check the list above, find the factor cause your hair loss and then find a solution. Well, this progress tends to base on a self-judgement. If you need precise information about your body and the cause, consulting professionals and conducting related physical examinations are both required.
 

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