PIK3IP1 Antibody

Code CSB-PA018002GA01HU
Size 100μl
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Trial Size 24T ELISA Kit Trial Size (Only USD$150/ kit)
* The sample kit cost can be deducted from your subsequent orders of 96T full size kits of the same analyte at 1/5 per kit, until depleted in 6 months. Apply now

Product Details

Alternative Names
HGFL antibody; hHGFL(S) antibody; Kringle domain containing protein HGFL antibody; Kringle domain-containing protein HGFL antibody; MGC17330 antibody; P3IP1_HUMAN antibody; Phosphoinositide 3 kinase interacting protein 1 antibody; Phosphoinositide-3-kinase-interacting protein 1 antibody; PIK3IP1 antibody
Abbreviation
PIK3IP1
Uniprot No.
Species
Homo sapiens (Human)
Troubleshooting
and FAQs
Storage
Store at 2-8°C. Please refer to protocol.

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Target Background

Function
(From Uniprot)
Negative regulator of hepatic phosphatidylinositol 3-kinase (PI3K) activity.
Gene References into Functions
  1. Findings indicate that colon cancer associated transcript 1 (non-protein coding) (CCAT1) was upregulated in osteosarcoma tissues and cells, and was involved in the proliferation and migration of osteosarcoma via regulating miR-148a/phosphatidyl inositol 3-kinase interacting protein 1 (PIK3IP1) signal pathway. PMID: 28549102
  2. These results suggest that the novel PI3K regulator PIK3IP1 plays an inhibitory role in T-cell activation. PMID: 22706993
  3. PIK3IP1-v1 is a novel splicing isoform of PIK3IP1. Both of them are located on cell membrane and can induce cell apoptosis. PMID: 19088825
  4. PIK3IP1 directly binds to the p110 catalytic subunit and down modulates PI3K activity. Suggested that PIK3IP1 is a new type of PI3K regulator. PMID: 17475214
  5. PIK3IP1 is an important regulator of PI3K in vivo, and its dysregulation can contribute to liver carcinogenesis PMID: 18632611

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Subcellular Location
Cell membrane; Single-pass type I membrane protein.
Database Links

HGNC: 24942

KEGG: hsa:113791

STRING: 9606.ENSP00000215912

UniGene: Hs.26670

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