RAB14 Antibody

1. Colorectal carcinoma (CRC) patients with elevated miR4903p amounts had prolonged overall survival. Ectopic expression of miR4903p in CRC cells resulted in decreased expression of RAB14, which was directly targeted by miR4903p, interacting with its 3'UTR. PMID: 29916545
2. Phosphorylation of RCP at Ser(435) by Lemur tyrosine kinase-3 (LMTK3) and of EphA2 at Ser(897) by Akt are both necessary to promote Rab14-dependent (and Rab11-independent) trafficking of EphA2 which generates cell:cell repulsion events that drive tumour cells apart. PMID: 28294115
3. RAB14 was identified as a direct target gene of miR-320a, according to the results of bioinformatics analysis and a luciferase reporter assay. Downregulation of RAB14 by RAB14-small interfering RNA inhibited the viability of Gastric Cancer cells, which was similar to the phenotype of miR-320a mimics. PMID: 28713899
4. The results from this analysis indicated that Rab11a, Rab11c(Rab25) and Rab14 were expressed in a wide range of cell lines, including the human placental trophoblastic BeWo cell line. PMID: 28922401
5. acst as oncogene and Induces proliferation of gastric cancer cells via AKT signaling pathway PMID: 28107526
6. Rab14-specific siRNA-induced downregulation of Rab14 increases the sensitivity to cisplatin, while forced expression of Rab14 lacking 3'-UTR abrogated the pro-apoptotic function of miR-148a in renal cancer cells. miR-148a acts as a tumor suppressor and holds great potential for renal cancer therapy by directly targeting Rab14. PMID: 28098870
7. PKCiota binds to Rab14 and that PKCiota requires Rab14 for its correct distribution in cells. As with Rab14, PKCiota protects claudin-2 from lysosomal degradation and, in consequence, modulates epithelial barrier. PMID: 25694446
8. We find that Rab14 indeed binds to RCP, albeit with reduced affinity relative to conventional Rab11-FIP and Rab25-FIP complexes. However, in vivo, Rab11 recruits RCP onto biological membranes. PMID: 26032412
9. RAB14 is a direct target of both MIR144 and MIR451. As MIR144 and MIR451 expression increased during human erythropoiesis, RAB14 protein expression decreased. RAB14 as a novel physiological inhibitor of human erythropoiesis. PMID: 25312678
10. the miR-451/RAB14 interaction plays an important role in the enhancement of radiosensitivity in NPC cells. PMID: 25201065
11. Data indicate that myosin Va interacted with multiple new Rab subfamilies including Rab6, Rab14 and Rab39B. PMID: 24006491
12. Rab5a, Rab8a and Rab14 are major regulators of MT1-MMP trafficking and invasive migration of primary human macrophages. PMID: 23606746
13. findings support a model for HIV-1 Env incorporation in which specific targeting to the particle assembly microdomain on the plasma membrane is mediated by FIP1C and Rab14 PMID: 23592992
14. FAM116 and Rab14 therefore define an endocytic recycling pathway needed for ADAM protease trafficking and regulation of cell-cell junctions. PMID: 22595670
15. Data suggest that targeting with the miR-451/RAB14 interaction might serve as a novel therapeutic application to treat NSCLC patients. PMID: 21358675
16. Data show that Rab14 facilitates the delivery of sphingolipids required for bacterial development and replication from the Golgi to chlamydial inclusions. PMID: 21124879
17. These findings suggest that Rab14 and Rab4 act sequentially, together with RUFY1. PMID: 20534812
18. identifies the class I Rab11-FIPs as the first putative effector proteins for the Rab14 GTPase PMID: 19702578

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HGNC: 16524

OMIM: 612673

KEGG: hsa:51552

STRING: 9606.ENSP00000362946

UniGene: Hs.371563