SEC24C Antibody

Code CSB-PA020952GA01HU
Size 100μl
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Trial Size 24T ELISA Kit Trial Size (Only USD$150/ kit)
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Product Details

Alternative Names
Protein transport protein Sec24C antibody; SC 24C antibody; SC24 C antibody; SC24C antibody; SC24C_HUMAN antibody; Sec 24C antibody; Sec24 C antibody; SEC24 related gene family, member C (S. cerevisiae) antibody; SEC24 related protein C antibody; SEC24-related protein C antibody; SEC24C antibody
Abbreviation
SEC24C
Uniprot No.
Species
Homo sapiens (Human)
Troubleshooting
and FAQs
Storage
Store at 2-8°C. Please refer to protocol.

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Target Background

Function
(From Uniprot)
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. Plays a central role in cargo selection within the COPII complex and together with SEC24D may have a different specificity compared to SEC24A and SEC24B. May more specifically package GPI-anchored proteins through the cargo receptor TMED10. May also be specific for IxM motif-containing cargos like the SNAREs GOSR2 and STX5.
Gene References into Functions
  1. AKT signaling played a role in ATX secretion regulation to facilitate ATX ER export by enhancing the nuclear factor of activated T cell-mediated p23 (Sec24C) expression PMID: 28298439
  2. Data indicate that a synthetic polypeptide containing the N terminus of bovine AE1 bound the Sec23A-Sec24C complex through a selective interaction with Sec24C. PMID: 23658022
  3. a lysine residing in the C terminus of the serotonin transporter specifies its preference for the coat protein complex II component SEC24C PMID: 23288844
  4. A triple arg motif mediates alpha(2B)-adrenergic receptor interaction with Sec24C/D and export PMID: 22404651
  5. The serotonin transporter is an exclusive client of the coat protein complex II (COPII) component SEC24C PMID: 21454670
  6. The interphase form of Sec24Cp was O-N-acetylglucosamine modified, a feature lost upon entering into mitosis. This mitotic deglycosylation was coupled to Sec24p phosphorylation, a process which may contribute to observed mitotic ER-to-Golgi traffic block. PMID: 15013749
  7. We found that Sec24C, a component of the host COPII vesicular transport system, interacts specifically with VP40 via VP40 amino acids 303 to 307. PMID: 18329616

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Subcellular Location
Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytosol.
Protein Families
SEC23/SEC24 family, SEC24 subfamily
Tissue Specificity
Ubiquitous.
Database Links

HGNC: 10705

OMIM: 607185

KEGG: hsa:9632

STRING: 9606.ENSP00000321845

UniGene: Hs.81964

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