SPAG11A Antibody

1. we report the three dimensional structure of the human SPAG11B proteins and their C-terminal peptides. web-based hydropathy, amphipathicity, and topology (WHAT) analyses and grand average of hydropathy PMID: 25573789
2. Isoform C of SPAG11B encodes a peptide with antimicrobial activity against E. coli. PMID: 16411022
3. Combination of two proteins, SPAG11B and TEX101, can be used for differential diagnosis of azoospermia PMID: 21933954
4. SPAG11B/D is both a substrate and a potent inhibitor of TPSAB1 activity. PMID: 19535787
5. HE2 peptides were detected in human epididymal epithelium, epididymal fluid, and ejaculate PMID: 12193388
6. HE2 transcriptional and translational products normally expressed in the caput epididymidis were not affected by vasectomy. PMID: 14662784
7. EP2 expression is more widespread in male reproductive tract than realized previously. Activity of every EP2 variant tested is antibacterial. Further investigation may reveal additional roles for EP2 peptides in primate male reproductive tract. PMID: 15229135
8. In the chimpanzee epididymis, several mRNA HE2/EP2 variants are produced. Of these, three cDNAs code for two different protein sequences that have a cysteine distribution characteristic for beta-defensins. PMID: 10819450
9. The human HE2/EP2 gene is the fusion product of two ancestral beta-defensin genes. During its evolution, the gene has acquired additional exons whose inclusion produces new message variants that encode peptides unrelated to defensins. PMID: 11259252

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HGNC: 33342

OMIM: 606560

KEGG: hsa:653423

STRING: 9606.ENSP00000381480

UniGene: Hs.2717