Scientists design an ACK1 inhibitor that suppresses prostate cancer growth
Scientists design an ACK1 inhibitor that suppresses prostate cancer growthIn a paper published in Cancer Cell, researchers at Moffitt Cancer Center reports a new epigenetic mechanism that contributes to castration-resistant prostate cancer, a finding that further extends our knowledge of this ...
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Nanoparticles may improve effectiveness of immunotherapy
Nanoparticles may improve effectiveness of immunotherapyResearchers from Johns Hopkins University School of Medicine have found an approach to improve the effectiveness of immunotherapy. Published in ACS Nano, the study shows that the new approach is able to inhibit tumor gro...
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Inhibiting DNA repair provides therapeutic benefits for ALL
Inhibiting DNA repair provides therapeutic benefits for ALLA new study shows that transient selective inhibition of HDAC1,2 may provide a therapeutic option for acute lymphoblastic leukemia (ALL). The study is led by Dr. Srividya Bhaskara at the University of Utah School of M...
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New tool for cancer detection
New tool for cancer detectionA team consisting of researchers from Griffith University, University of Adelaide, and The University of Queensland in Australia has developed a tool to improve the detection of cancer. The study, "Structure aided des...
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Researchers studying HED have gained a better understanding of baldness
Researchers studying HED have gained a better understanding of baldnessStudying rare disorders may provide insights into more common diseases. Now a team of researchers studying hypohidrotic ectodermal dysplasia have found that certain mutations associated with this disorder may underlie ma...
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Natural sugar found to ameliorate atherosclerosis
Natural sugar found to ameliorate atherosclerosisTrehalose, a natural sugar found in plants and insects, can strengthen the ability of immune cells to clear atherosclerotic plaques, according to a study published yesterday in the journal Nature Communications. The find...
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A mutation in OBSCN contributes to heart disease
A mutation in OBSCN contributes to heart diseaseAccording to the WHO, ischaemic heart disease accounted for 8.76 millions of death in 2015, ranking the first among all the causes of death. Heart disease is a result of the combination of environmental factors and genet...
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Drinking tea changes females' epigenetics
Drinking tea changes females' epigeneticsCancer is a disease of genetic susceptibility and epigenetic abnormalities. Epigenetic alterations refer to potentially heritable changes in gene expression that do not change DNA sequence. The scientific interest in epi...
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Diabetes drug protects against heart disease
Diabetes drug protects against heart diseaseLinagliptin is a drug used to lower blood sugar in patients with type 2 diabetes, a disease characterized by high blood sugar and insulin resistance. Now researchers at the University of Missouri and Boehringer Ingelheim...
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New drug delivery method could improve pain treatment
New drug delivery method could improve pain treatmentScientists have found an effective way to block pain transmission, a finding that may greatly improve the treatment of pain. Chronic pain is a common condition that everyone would encounter. In the USA alone, 40-50 mi...
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A microRNA molecule prevents epilepsy in mice
A microRNA molecule prevents epilepsy in miceAs the fourth most common neurological disorder, epilepsy affects approximately 50 million people worldwide. The disease is characterized by unpredictable seizures. Epileptic seizures can be triggered by many different f...
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Gene critical for muscle formation identified
Gene critical for muscle formation identifiedCell fusion is important for the development and physiology of mammals. But which factors are involved in this process is not entirely clear. Now a team of researchers at Cincinnati Children's Hospital Medical Center hav...
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How can chemicals in everyday products contribute to cancer?
How can chemicals in everyday products contribute to cancer?Researchers at the University of Cambridge in the UK and Eidgen ssische Technische Hochschule in Switzerland have demonstrated how a common class of environmental toxins contribute to cancer. Aldehydes, a class of org...
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Olive oil ingredient may provide protection against brain tumor
Olive oil ingredient may provide protection against brain tumorA study at the University of Edinburgh finds that a chemical found in olive oil may provide protection against brain tumor. Described 5 May 2017 in the Journal of Molecular Biology, the study shows that a chemical com...
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Combination therapy shows therapeutic effects in RAS-mutant cancers
Combination therapy shows therapeutic effects in RAS-mutant cancersA new research suggests that combining PARP inhibitors with MEK inhibitors might be a therapeutic approach to RAS-mutant cancers. The research was conducted by the University of Texas MD Anderson Cancer Center, the Un...
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HDAC inhibitors are a promising therapy for psoriasis
HDAC inhibitors are a promising therapy for psoriasisAccording to a study appearing in the journal Investigative Dermatology, a powerful class of cancer drugs -- HDAC inhibitors -- might also be used to treat psoriasis. Psoriasis is a common, long-lasting skin disease a...
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Oxytocin attenuates drug addiction in rats
Oxytocin attenuates drug addiction in ratsMeth, an abbreviation for methamphetamine, is a powerfully addictive stimulant that affects the central nervous system. Meth is meant to treat ADHD and obesity. However, it is commonly abused as a recreational drug. Curr...
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Research uncovers the role of DPF2 in AML
Research uncovers the role of DPF2 in AMLA team of researchers from California Institute of Technology, University of Miami Miller School of Medicine, and Memorial Sloan Kettering Cancer Center has uncovered how a protein modulates blood cell production in acut...
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Glycoprotein C facilitates the spread of VZV
Glycoprotein C facilitates the spread of VZVVaricella-zoster virus (VZV) is a prevalent human pathogen that belongs to the α-herpesvirus family. Clinical and epidemiological evidence shows that primary infection causes chickenpox (varicella), which most commonly ...
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Crhr2 may be a novel drug target for heart failure
Crhr2 may be a novel drug target for heart failureA team of researchers from Japan, Germany, and the USA has identified a receptor protein on heart cells that may cause chronic heart dysfunction. Published in The Journal of Experimental Medicine, the finding suggests th...
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HIV vaccine design has made breakthrough progress
HIV vaccine design has made breakthrough progressA team of researchers from The Scripps Research Institute (TSRI) has designed a new immunogen based on the structures of the envelope glycoprotein from a common HIV subtype, HIV-C. This immunogen may aid in developing a ...
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Removing Tudor-SN delays cancer cell growth
Removing Tudor-SN delays cancer cell growthA protein called Tudor-SN is associated with the preparatory phase of the cell division, according to a study published online today in the journal Science. The study, led by the University of Rochester, Rutgers Universi...
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Discovery of novel CARM1 targets is hoped to facilitate the development of new therapeutics for breast cancer
Discovery of novel CARM1 targets is hoped to facilitate the development of new therapeutics for breast cancerUsing a quantitative mass spectrometry approach, researchers at the University of Wisconsin – Madison have globally profiled the protein targets of CARM1 in breast cancer. CARM1, a methyltransferase, has long been impl...
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Inhibition of GRP78 may impede development of pancreatic cancer
Inhibition of GRP78 may impede development of pancreatic cancerScientists at the University of Southern California (USC) have shed light on pancreatic tumorigenesis. Published in the latest issue of the Proceedings of the National Academy of Sciences, the study describes an approach...
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An existing antibiotic may improve TB treatment
An existing antibiotic may improve TB treatmentTuberculosis (TB) and human immunodeficiency virus (HIV) are both global epidemics that claim many people's lives each year. The bacterium Mycobacterium tuberculosis (Mtb) is the cause agent of TB. According to the Cente...
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A drug called BEZ235 may help fight against influenza
A drug called BEZ235 may help fight against influenzaResearchers from the St. Jude Children's Research Hospital and the University of Tennessee Health Science Center have developed an approach to fight against influenza, or called the flu. Influenza is quite prevalent w...
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Study identifies a previously unknown role of PD-L1 in cancer
Study identifies a previously unknown role of PD-L1 in cancerImmunotherapy has emerged as an important treatment for cancer patients. It uses substances that restore or enhance the immune system's natural ability to fight cancer. However, clinicians note a variety of side effects ...
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Fragment of C3 amplifies anti-tumor responses
Fragment of C3 amplifies anti-tumor responsesA team of researchers from the University of Michigan, UCLA, The University of Georgia, and Harvard Medical School has found that free C3d, a fragment of the protein C3 (complement component 3), enhances anti-tumor respo...
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Manipulating DNA repair response is a promising therapeutic strategy for immune diseases
Manipulating DNA repair response is a promising therapeutic strategy for immune diseasesTherapeutic immune suppression is an important treatment strategy for many immune conditions, such as autoimmune disorders, immunoregulatory disorders, and in transplantation. Since immune pathways typically have essenti...
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TIAM1 predicts outcome of patients with neuroblastoma
TIAM1 predicts outcome of patients with neuroblastomaA team of researchers led by Jaime Font de Mora from Instituto de Investigación Sanitaria La Fe has identified a molecular target that may improve the outcome of patients with neuroblastoma (NB), the most common cancer ...
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Study sheds light on the mechanism of epilepsy and intellectual disability
Study sheds light on the mechanism of epilepsy and intellectual disabilityIntellectual disability (ID), once called mental retardation, is a generalized neurodevelopmental disorder characterized by limitations in intellectual functioning and in adaptive behavior. ID is estimated to affect 2-3%...
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Anti-LAP antibody helps kill cancer cells
Anti-LAP antibody helps kill cancer cellsScientists studying multiple sclerosis have stumbled upon a finding that a specific antibody enhances antitumor immune responses in several types of cancer. The study, led by Howard Weiner at Harvard Medical School and p...
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Novel approach to combating MERS-CoV
Novel approach to combating MERS-CoVResearchers from Canada and the Netherlands have developed a novel approach to combating a coronavirus named MERS-CoV, the cause agent of Middle East respiratory syndrome (MERS). MERS is a viral respiratory illness th...
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Antibody drug conjugate may tackle drug-resistant ALL
Antibody drug conjugate may tackle drug-resistant ALLA collaborative team has found a new way to treat acute lymphoblastic leukemia (ALL), the most common form of cancer among children. The study, conducted by investigators from the University of Manchester in the UK, T...
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Scientists identify a genetic variant that confers resistance to malaria
Scientists identify a genetic variant that confers resistance to malariaA team of researchers from the UK, the USA, the Gambia, Burkina Faso, Italy, Cameroon, Kenya, Tanzania, and Malawi recently has identified a genetic variant that reduces the risk of severe malaria by 40%. The finding may...
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Research reveals protective role of CD14 in IBD
Research reveals protective role of CD14 in IBDResearchers at Hannover Medical School, along with those from the University of Erlangen-Nürnberg, have found that the CD14 protein appears to play a protective role in the development of inflammatory bowel disease (IBD...
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Three specific proteins predict the risk of diabetic nephropathy
Three specific proteins predict the risk of diabetic nephropathyDiabetes can cause a wide range of complications such as retinopathy, neuropathy, and nephropathy, which are responsible for considerable morbidity. Diabetic nephropathy, also known as diabetic kidney disease, is a frequ...
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Cause of cancer-associated kidney injury identified
Cause of cancer-associated kidney injury identifiedA new study, carried out by investigators from Uppsala University and Dalarna University in Sweden, uncovers the mechanism by which a tumor contributes to kidney dysfunction and provides a potential approach to prevent k...
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IFN-λ3 may mediate liver fibrosis
IFN-λ3 may mediate liver fibrosisAn international team consisting of scientists from Australia, Italy, Germany, Egypt, UK, Denmark and Spain has identified a protein that is responsible for liver fibrosis, a discovery that will open an avenue for treati...
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Variant in UBQLN4 gene is linked to ALS, study finds
Variant in UBQLN4 gene is linked to ALS, study findsScientists at Northwestern University Feinberg School of Medicine have linked a novel variant in the UBQLN4 gene to amyotrophic lateral sclerosis (ALS), the most common adult-onset motor neuron disease. ALS, also know...
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Study extends our knowledge of spinal muscular atrophy
Study extends our knowledge of spinal muscular atrophyResearchers at Columbia University have gained some new insights into the cause and mechanism of spinal muscular atrophy (SMA), a rare, genetic disorder that affects the control of muscle movement. Published online 15 Ma...
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Diagnostic biomarker of mevalonate kinase deficiency identified
Diagnostic biomarker of mevalonate kinase deficiency identifiedMevalonate kinase deficiency (MKD) is a rare, inherited auto-inflammatory disease that disrupts the production of cholesterol and isoprenoids. The disease is most often caused by mutation of the mevalonate kinase (MVK) g...
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Drugs that block LTB4 ameliorate lymphedema
Drugs that block LTB4 ameliorate lymphedemaA team led by scientists at VA Palo Alto Health Care System and Stanford University School of Medicine has found a potential therapy strategy for lymphedema, a common painful condition for which there are no targeted tre...
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JHUSOM researchers uncover the oncogenic function of CHD4 in colon cancer
JHUSOM researchers uncover the oncogenic function of CHD4 in colon cancerDescribed in the journal Cancer Cell and led by The Johns Hopkins University School of Medicine (JHUSOM), a study has shown that a protein that normally stops cells from transcribing faulty DNA and helps eliminate potent...
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New study may lead to a cure for baldness
New study may lead to a cure for baldnessInvestigators from the University of Texas Southwestern Medical Center (UT Southwestern) have stumbled upon a finding that may lead to a cure for balding and hair graying. Published in an advance online publication by th...
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SIRT6 deficiency may contribute to neurodegeneration
SIRT6 deficiency may contribute to neurodegenerationAging is considered a result of DNA damage accumulation. Both normal metabolic activities and environmental factors can cause DNA damage in human cells. Human cells employ multiple DNA repair mechanisms to monitor and re...
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Scientists discover a tumor suppressor of liver cancer
Scientists discover a tumor suppressor of liver cancerSCRIB is a scaffold protein that in humans is encoded by the SCRIB gene. This protein is found as a membrane protein and it regulates the establishment of apical-basal cell polarity of the epithelial tissues. Previous st...
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Antibiotic shows promise in treating Parkinson's disease
Antibiotic shows promise in treating Parkinson's diseaseDoxycycline, an antibiotic typically used to treat infections caused by bacteria and protozoa, shows promise as an effective treatment for the neurodegenerative disorder Parkinson's disease (PD), according to a study pub...
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Researchers identify genetic mutation responsible for a rare skin disease
Researchers identify genetic mutation responsible for a rare skin diseaseAn international research team consisting of researchers from South Africa, the Netherlands, Norway, USA, Switzerland and Canada has identified genetic mutation that is responsible for keratolytic winter erythema (KWE), ...
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Novel clues to eczema
Novel clues to eczemaA study, led by researchers from Newcastle University (NU) and GlaxoSmithKline, gains new insights into the pathogenesis of atopic dermatitis (eczema), a chronic inflammatory skin disease characterized by dry, itchy swol...
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