Loss of p300 may cause myelodysplastic syndrome to develop into leukemia
Loss of p300 may cause myelodysplastic syndrome to develop into leukemiaMyelodysplastic syndrome (MDS) is a group of diseases in which the bone marrow does not produce enough healthy blood cells. The disease primarily affects the elderly but can also affect young people. In MDS, stem blood c...
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Research shows how breast cancer cells can become resistant to treatment
Research shows how breast cancer cells can become resistant to treatmentBreast cancer cells may become resistant to treatment. Sometimes, even the latest drugs fail to work. The PI3K pathway is implicated in many cancers among women, including breast cancer. So inhibiting it represents a tre...
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Study links a new gene to tauopathy
Study links a new gene to tauopathyNeurofibrillary tangles (NFTs) -- aggregates of abnormally formed tau protein -- occur as part of the normal aging process. But in certain diseases such as Alzheimer's disease (AD), Lytico-Bodig disease, and Postencephal...
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Inhibiting TRAF3IP2 alleviates post-heart attack injury
Inhibiting TRAF3IP2 alleviates post-heart attack injuryPublished in the Journal of Biological Chemistry, a study indicates that targeting a protein called TRAF3IP2 (TRAF3 Interacting Protein 2) by genetic and interventional methods could be a way to alleviate post-heart atta...
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New research extends the understanding of Campylobacter infection
New research extends the understanding of Campylobacter infectionFindings of a new study published in the journal Scientific Reports could aid in developing a poultry vaccine against Campylobacter, bacteria that are a leading cause of food poisoning and gastroenteritis. The study i...
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Promising way to reverse aging
Promising way to reverse agingFindings of a new study published in Science could lead to effective anti-ageing drugs. The study, led by researchers from Harvard Medical School, University of Rochester, Mayo Clinic, University of Bayreuth, and The ...
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Research links OTUD6B gene to an intellectual disability syndrome
Research links OTUD6B gene to an intellectual disability syndromeFor the first time, scientists have found that a gene called OTUD6B is involved in human disease. The study, led by researchers at Baylor College of Medicine, has shown that mutations in OTUD6B can cause physical and int...
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Why exercise improves bone health?
Why exercise improves bone health?Specific exercises such as resistance training and jump training can improve bone health, according to a study published in the journal Bone. The study is carried out by researchers including Pamela Hinton, Peggy Nigh, a...
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Heroin addiction is associated with epigenetic impairments
Heroin addiction is associated with epigenetic impairmentsOpiate abuse and overdose have become a major public health concern. To understand the molecular basis of opiate addiction, scientists have carried out many experiments in animal and in vitro models. But little is known ...
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Inhibition of en enzyme reduces depression symptoms in mice
Inhibition of en enzyme reduces depression symptoms in miceAs a common mood disorder, depression is estimated to affect 19 million people in the USA. People with depression experience overwhelming feelings of sadness, unpleasure, guilt and hopelessness, which interfere with dail...
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Coagulation factor XII appears to play a role in Alzheimer's disease
Coagulation factor XII appears to play a role in Alzheimer's diseaseA study, led by The Rockefeller University researchers in collaboration with researchers from IONIS Pharmaceuticals Inc, has revealed that the coagulation factor XII may play a role in the development of Alzheimer's dise...
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Podoplanin protein is involved in the formation of thrombosis in cancer
Podoplanin protein is involved in the formation of thrombosis in cancerIn a paper published in the journal Blood, a research team consisting of scientists from the Medical University of Vienna and the Medical University of Graz reports that a protein called podoplanin is involved in the for...
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Hi1a protein might be a potential treatment for stroke
Hi1a protein might be a potential treatment for strokeA team of researchers headed by Professor Glenn King from The University of Queensland has identified a small protein that shows promise in reducing brain damage after a stroke. The protein, called Hi1a, is found in ...
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New therapeutic targets for mucosal melanoma identified
New therapeutic targets for mucosal melanoma identifiedMelanoma is a rare but aggressive form of skin cancer: it accounts for only 2% of all skin cancers but causes most deaths from skin cancer. Most cases of melanoma result from too much exposure to ultraviolet radiation wh...
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New clues to the mechanism of inflammatory bowel disease
New clues to the mechanism of inflammatory bowel diseaseInflammatory bowel disease (IBD) describes a group of conditions that involve chronic immune response and inflammation of the gastrointestinal tract. Ulcerative colitis and Crohn disease are the two major types of IBD. I...
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Research sheds light on how a human antibody neutralizes the Zika virus
Research sheds light on how a human antibody neutralizes the Zika virusThe Zika virus (ZIKV) has been linked to birth defects such as microcephaly and the severe autoimmune disease Guillian-Barré syndrome. One potential strategy to combat the dangerous virus is the use of neutralizing anti...
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New explanation for why sulforaphane has anti-tumor effect
New explanation for why sulforaphane has anti-tumor effectIn a paper published in the Journal of Nutritional Biochemistry, a team of researchers from Oregon State University and the Texas A&M Health Science Center has demonstrated that a natural compound found in certain ve...
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Myb regulates the function of regulatory T cells
Myb regulates the function of regulatory T cellsDescribed in the journal Immunity, a study of the University of Melbourne reveals that the transcription factor Myb modulates the function of a subtype of immune cells, called regulatory T (Treg) cells. Treg cells mai...
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Anti-CD47 antibody shows promise against childhood brain tumors
Anti-CD47 antibody shows promise against childhood brain tumorsA study led by researchers from the USA, Canada, Germany, and Switzerland now has shown that a humanized antibody that blocks the CD47 protein on tumor cells shows promise against a variety of pediatric brain tumors. The...
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Research adds to evidence that GABA is implicated in schizophrenia
Research adds to evidence that GABA is implicated in schizophreniaAccording to a paper published online in "Molecular Psychiatry," a key neurotransmitter known as gamma-Aminobutyric acid (GABA) is reduced in individuals with schizophrenia and is associated with symptom severity. The st...
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GRIN2A mutations contribute to epilepsy
GRIN2A mutations contribute to epilepsyResearchers from the King's College London and the Eli Lilly Research Centre in the UK have demonstrated how genetic mutations can lead to epilepsy-aphasia spectrum, a group of genetic epilepsy syndromes characterized by...
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Early antibody treatment provides long-lasting protection against HIV-like virus
Early antibody treatment provides long-lasting protection against HIV-like virusThere have been a series of HIV medications, such as nucleoside/nucleotide reverse transcriptase inhibitors, non-nucleoside reverse transcriptase inhibitors, protease inhibitors, fusion inhibitors, and integrase inhibito...
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A specific enzyme promotes metastasis of prostate cancer to bones
A specific enzyme promotes metastasis of prostate cancer to bonesDescribed in "Cancer Cell," a study shows that an enzyme called monoamine oxidase A (MAOA) promotes the metastasis of prostate cancer to bones. The study, led by researchers from Cedars-Sinai Medical Center, the Secondar...
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New clues to the formation of stress granules
New clues to the formation of stress granulesStress granules are aggregates of proteins and RNA molecules that are produced by the cells in response to environmental stress. The formation of stress granules is crucial for cell survival under different conditions. U...
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Analysis of angiogenin mutations provides insight into neurodegenerative disease
Analysis of angiogenin mutations provides insight into neurodegenerative diseaseAngiogenin is a protein that plays a role in stimulating angiogenesis, the process of blood vessel formation. Various mutations in angiogenin have been found to correlate to Parkinson's Disease (PD) and Amyotrophic Later...
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Researchers identify a new gene that influences survival of glioma patients
Researchers identify a new gene that influences survival of glioma patientsGlioma refers to any type of tumor that originates from the glial cells, a group of cells that surround neurons and provide support for and insulation between them. The disease usually affects the brain but is also found...
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Study links an autism gene to cancer
Study links an autism gene to cancerPublished 6 March 2017 in the journal Nature Cell Biology, a study led by researchers from Finland, the UK, and Germany shows that a protein called SH3 and multiple ankyrin repeat domains 3 (SHANK3) is able to prevent th...
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Study demonstrates the possibility to harness macrophages to fight cancer
Study demonstrates the possibility to harness macrophages to fight cancerThe majority of existing cancer immunotherapies manipulate the behavior of T cells, a subtype of white blood cells that belong to the adaptive immune system. Another arm of the body's immune system, the innate immune sys...
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New biomarker for sepsis identified
New biomarker for sepsis identifiedA molecule called methylthioadenosine (MTA) could be a biomarker to predict which patients are most likely to die of sepsis, according to a new study carried out by researchers at Duke University in the USA and the Unive...
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ITGB3 protein regulates cellular senescence, study finds
ITGB3 protein regulates cellular senescence, study findsCellular senescence is the point at which cells in the body cease to divide. It is a fundamental mechanism that helps control cellular lifespan and prevents the propagation of damaged cells. Prior studies have suggested ...
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IU scientists identify compounds that may help prevent neurodegenerative diseases
IU scientists identify compounds that may help prevent neurodegenerative diseasesScientists from Indiana University (IU) report in the journal Scientific Reports that they have identified 24 molecules that could increase the production of an enzyme called NMNAT2 in the brain of mouse models. This enz...
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Study provides insight into the genetic mechanism of Berger's disease
Study provides insight into the genetic mechanism of Berger's diseaseBerger's disease, or referred to as IgA nephropathy, is an inflammation of the glomeruli of the kidney. The disease occurs when a type of antibody called immunoglobulin A (IgA) lodges in the kidneys, causing inflammation...
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New drug relieves pain without causing adverse effects
New drug relieves pain without causing adverse effectsIn a paper published in the respected journal Science, scientists from Freie Universität Berlin, Germany, say that they have developed a novel type of opioid to relieve pain. Experiments in rats demonstrate the efficacy...
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Gene variants in ABCB1/ABCB4 region confer gallbladder cancer risk
Gene variants in ABCB1/ABCB4 region confer gallbladder cancer riskAn in-depth genetic analysis of people with or without gallbladder cancer by researchers at the National Institutes of Health (NIH) points to several gene variants that may explain why some people are susceptible to the ...
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Scientists find a way to inhibit metastasis of ovarian cancer
Scientists find a way to inhibit metastasis of ovarian cancerA team, led by researchers at the University of Illinois, has revealed that inhibiting a protein found on cell surface could prevent the metastasis of ovarian cancer. The findings were published 12 December 2016 in the j...
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Nrf2-Keap1 inhibitors may slow Alzheimer's disease progression
Nrf2-Keap1 inhibitors may slow Alzheimer's disease progressionNrf2 (nuclear factor E2-related factor 2) is a transcription factor that regulates the expression of a range of cell protection genes. Activation of these protective genes enables the cell to maintain healthy and to get ...
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New discovery may boost asthma therapies
New discovery may boost asthma therapiesIn a paper published in the Journal of Allergy and Clinical Immunology, researchers at the University of Leicester report that an important protein, which is involved in the narrowing of the airway, is up-regulated in pa...
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Increasing a cytokine slows colon cancer growth in mice
Increasing a cytokine slows colon cancer growth in miceIncreasing a molecule found in tumors could slow the growth of colon cancer in mice, according to the results of a study published in January 2017 in the journal Cancer Research. The molecule is an immunostimulatory c...
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Study points to a way to treat African swine fever in pigs
Study points to a way to treat African swine fever in pigsAfrican swine fever is a highly contagious hemorrhagic disease of pigs. Currently, there is no published treatment or vaccine for the disease. Mortality rates may be as high as 100%. The causative agent of the disease is...
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New biomarkers may improve early diagnosis of pancreatic cancer
New biomarkers may improve early diagnosis of pancreatic cancerA team headed by Dr Ann Killary from The University of Texas MD Anderson Cancer Center now find that two proteins known as TFPI and TNC may improve the early diagnosis of pancreatic cancer. The findings, which will be pu...
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Combining two cancer drugs improves survival of mice infected with dengue or Ebola viruses
Combining two cancer drugs improves survival of mice infected with dengue or Ebola virusesDengue virus is a member of the virus genus Flavivirus. Ebola virus is one of five known viruses within the genus Ebolavirus. The two viruses have very little in common. But now scientists find that a combination of two ...
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Molecule inhibits the progression of diffuse intrinsic pontine glioma
Molecule inhibits the progression of diffuse intrinsic pontine gliomaNew research provides a way to combat a deadly brain tumor in children. Diffuse intrinsic pontine glioma, commonly referred to as DIPG, is a type of tumor that starts in an area of the brain stem called pons, which he...
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Indels in non-coding DNA also contribute to cancer
Indels in non-coding DNA also contribute to cancerCancer is a large group of diseases characterized by uncontrolled growth of abnormal cells in the body. These abnormal cells harbor the potential to invade other parts of the body. The World Health Organization says that...
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Study uncovers a connection between hyperglycaemia and Alzheimer's disease
Study uncovers a connection between hyperglycaemia and Alzheimer's diseaseAccording to a study published in the journal Scientific Reports, researchers at the University of Bath have made a breakthrough in understanding the pathogenesis of Alzheimer's disease, the most common type of dementia....
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Some patients with uterine leiomyosarcoma may respond to PI3K/mTOR inhibitors
Some patients with uterine leiomyosarcoma may respond to PI3K/mTOR inhibitorsUterine sarcoma is a rare cancer that occurs when malignant cells form in the muscle and supporting tissues of the uterus. Uterine sarcomas are heterogeneous tumors and usually have an aggressive clinical behavior. Based...
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Inhibiting PAK1 increases survival of mice with pancreatic cancer
Inhibiting PAK1 increases survival of mice with pancreatic cancerAustralian researchers identify PAK1 as a regulator of the activation, proliferation, and apoptosis of pancreatic stellate cells. The study, led by researchers from the University of Melbourne and the University of New S...
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BTK regulates inflammation activation
BTK regulates inflammation activationInflammation is the body's attempt to remove harmful stimuli, including damaged cells, pathogens and irritants, and to initiate healing of tissue. It is a protective response involving host cells, blood vessels, and prot...
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Newly identified mutations in bacteria confer resistance to multiple antibiotics
Newly identified mutations in bacteria confer resistance to multiple antibioticsIn an article published in eLife, a team led by Deborah Hung at The Broad Institute of MIT and Harvard report that they have identified new bacterial mutations that help resist antibiotic treatment. Antibiotics are am...
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New clues to mechanism of thyroid cancer
New clues to mechanism of thyroid cancerThyroid cancer occurs when abnormal cells grow in the thyroid gland, an organ that makes hormones to regulate heart rate, blood pressure, body temperature and weight. The cancer is relatively uncommon compared to other c...
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Approach to monitor the effect of annual flu vaccination
Approach to monitor the effect of annual flu vaccinationIn an article published in Science Immunology, E. John Wherry and co-workers report that they have found an approach to detect a type of circulating helper T cells in the blood after an annual flu vaccine. The approach w...
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