Warburg effect contributes to cancer development
Warburg effect contributes to cancer developmentAbout a century ago, a German biochemist named Otto Warburg noticed that cancer cells fundamentally change their metabolism. For example, cancer cells exhibit an increased rate of glycolysis even in the presence of oxyge...
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Study solves a mystery about AML
Study solves a mystery about AMLWriting in the Journal of Experimental Medicine, a team of researchers from Leibniz Institute for Experimental Virology, Engelhardt Institute for Molecular Biology, Johann Wolfgang Goethe-University and Linköping Univer...
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Michigan researchers uncover a new mechanism of hidden hearing loss
Michigan researchers uncover a new mechanism of hidden hearing lossDescribed in Nature Communications, a study reveals a second cause of hidden hearing loss, an auditory neuropathy that contribute to speech discrimination and intelligibility deficits in individuals considered to have no...
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New discovery brings hope for Alzheimer's patients
New discovery brings hope for Alzheimer's patientsAlzheimer's disease is a form of dementia that impairs memory, thinking, and behavior. The disease predominantly affects people over the age of 60. Symptoms develop slowly and get worse over time, eventually interfering ...
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Scientists identify a mutation that influences infectivity of flaviviruses
Scientists identify a mutation that influences infectivity of flavivirusesFlavivirus is a genus of viruses in the family Flaviviridae, including about 75 species. It includes the West Nile virus, dengue fever virus, tick-borne encephalitis virus, yellow fever virus, Zika virus and some other v...
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Nodding syndrome may be caused by immune responses to parasite
Nodding syndrome may be caused by immune responses to parasiteDescribed in Science Translational Medicine, a study provides clues to the pathogenesis of Nodding syndrome, a unique seizure disorder affecting children in certain countries in East Africa. The study was conducted by in...
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Study provides a powerful weapon against schistosomiasis
Study provides a powerful weapon against schistosomiasisSchistosomiasis is a detrimental disease caused by parasitic flatworms called schistosomes. It is one of the most common parasitic diseases in the world. According to the World Health Organization estimates, schistosomia...
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Researchers find a genetic signature of type 2 diabetes
Researchers find a genetic signature of type 2 diabetesType 2 diabetes (T2D), the most common form of diabetes, is a long-term disorder in which the body does not use insulin properly. This is called insulin resistance. Insulin is a hormone that lets the cells turn glucose f...
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Research reveals the role of SMN protein in spinal muscular atrophy
Research reveals the role of SMN protein in spinal muscular atrophySpinal muscular atrophy, which is the leading genetic cause of early childhood lethality, is a disease that affects motor neurons in the spinal cord. The disease is caused by alterations in the SMN1 gene, which codes for...
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Duke researchers reveal a pathway that can be modulated to treat Huntington's
Duke researchers reveal a pathway that can be modulated to treat Huntington'sA new research appearing in Nature Communications provides an insight into why a cellular process that is responsible for repairing or removing misfolded proteins is disrupted in Huntington's disease. Huntington's is ...
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Plant-based platform helps develop hemophilia treatment
Plant-based platform helps develop hemophilia treatmentA team consisting of researchers from the University of Pennsylvania and the University of Florida has found an approach to treat hemophilia, a rare disorder in which the blood does not clot normally. Individuals with...
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New discovery could lead to novel treatments for lupus
New discovery could lead to novel treatments for lupusSystemic lupus erythematosus, referred to as SLE or lupus, is an autoimmune disease that can cause severe inflammation, pain, and tissue damage throughout the body. It occurs when the immune system attacks healthy tissue...
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How malaria parasite invades blood cells?
How malaria parasite invades blood cells?Published in Nature Communications, a study of Wellcome Trust Sanger Institute (WTSI) demonstrates how the parasite that causes malaria gets into a cell. The finding could facilitate the development of malaria vaccines. ...
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A type of bacterium is linked with spondyloarthritis in Crohn's disease patients
A type of bacterium is linked with spondyloarthritis in Crohn's disease patientsCrohn's disease is a common form of inflammatory bowel disease affecting the gastrointestinal tract. Worldwide, about five million people are living with Crohn's disease. Typical symptoms include abdominal pain, diarrhea...
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Omega-3 fatty acid inhibits asthma by reducing IgE antibody
Omega-3 fatty acid inhibits asthma by reducing IgE antibodyA new study appearing in the Journal of Clinical Investigation—Insight has demonstrated the therapeutic effect of fish oil on asthma. The study, carried out by Nina Kim, Thomas Thatcher, Patricia Sime and Richard Phipp...
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New research points to an approach to combat TB
New research points to an approach to combat TBA paper in eLife provides a new way to fight against tuberculosis (TB), an epidemic disease that is caused by the bacterium Mycobacterium tuberculosis (Mtb). The researchers, including lead researcher Elizabeth Campbell ...
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How does TREM2 protein influence Alzheimer's progression?
How does TREM2 protein influence Alzheimer's progression?In a paper published in the Journal of Neuroscience, a team of researchers led by Gary Landreth at Western Reserve University has clarified the effects of TREM2 deficiency in a mouse model of Alzheimer's disease. Their f...
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SUMO seems to be associated with congenital heart defects
SUMO seems to be associated with congenital heart defectsA team led by Prof Norman Dovichi at University of Notre Dame has found that the disruption of a group of proteins may contribute to congenital heart defects. The findings, published by Scientific Reports, extend our und...
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Targeting NCoR1 is a way to treat newborn jaundice
Targeting NCoR1 is a way to treat newborn jaundiceA team of researchers from University of California, Ecole Polytechnique Fédérale de Lausanne and The Salk Institute for Biological Studies has identified a protein that inhibits the enzyme UGT1A1. This enzyme is known...
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DZNE researchers find a drug target for tauopathies
DZNE researchers find a drug target for tauopathiesA collaborative team led by Günter U Höglinger at the German Center for Neurodegenerative Diseases (DZNE) has identified a new drug target for progressive supranuclear palsy, an uncommon brain disorder affecting moveme...
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Proteins that regulate bone regeneration identified
Proteins that regulate bone regeneration identifiedTsung-Lin Tsai and Wan-Ju Li from the University of Wisconsin-Madison have revealed that two proteins known as lipocalin-2 and prolactin regulate bone regeneration. Described in Stem Cell Reports, their findings may help...
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Amplification of EMSY disrupts DNA damage repair
Amplification of EMSY disrupts DNA damage repairBRCA1 and BRCA2, which are tumor suppressor genes, are essential for the repair of double-strand DNA breaks. Mutations in BRCA have been identified as a hallmark of breast and ovarian cancer. So a blood test is being use...
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Increasing a protein restores associative memory in mice
Increasing a protein restores associative memory in miceA study published in Biological Psychiatry gives hope of possible therapeutic approaches to treating memory loss. Associative memory refers to the ability to learn and remember the relationship between unrelated ...
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Study provides a way to prevent osteogenesis imperfecta
Study provides a way to prevent osteogenesis imperfectaA team led by researchers from the University of Missouri and University of Missouri–Kansas City has found that a maternal protein has an effect on offspring bone health. The researchers decreased the levels of the pro...
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Study reveals the role of Parkin and PINK1 in Parkinson's disease
Study reveals the role of Parkin and PINK1 in Parkinson's diseaseAs one of the most common age-related neurodegenerative disorders, Parkinson's disease (PD) affects approximately 1% of people aged 60 and above. The incidence has been increasing in recent several decades. In a paper...
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ACTN3 is associated with Duchenne muscular dystrophy
ACTN3 is associated with Duchenne muscular dystrophyNew research reveals that a gene associated with athletic performance has an impact on the severity and progression of Duchenne muscular dystrophy (DMD), a disease characterized by progressive muscle degeneration and wea...
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Protein Akt plays a role in the development of memory T cells
Protein Akt plays a role in the development of memory T cellsThere are several defenses in our body that protect us from diseases and infections. Cytotoxic T cells are a subset of lymphocytes that kill cancer cells, cells that are infected with pathogens, or other damaged cells. C...
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mRNA-based vaccine provides strong protection against Zika virus
mRNA-based vaccine provides strong protection against Zika virusDescribed in the journal Nature on 2 February 2017, a study demonstrates the effectiveness and safety of a new Zika vaccine candidate. A single dose of the vaccine is enough to protect mice and monkeys. The study was led...
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Research reveals genetic features of HPV-negative cervical cancer
Research reveals genetic features of HPV-negative cervical cancerCervical cancer is a cancer that arises from the cervix. It results from the uncontrolled growth of cells in the cervix. Cervical cancer typically has no early signs or symptoms, which contributes to the mortality of the...
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Verapamil greatly improves the symptoms of chronic rhinosinusitis
Verapamil greatly improves the symptoms of chronic rhinosinusitisRhinosinusitis, also called sinusitis, is an inflammation of the sinuses, the tissues that surround the nasal passage. According to patient history and physical examination, rhinosinusitis can be divided into four subtyp...
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Elephant p53 kills human cancer cells
Elephant p53 kills human cancer cellsElephants are large mammals, and they can live up to 70 years. They are born at about 300 pounds and can reach the weight of 10,000 pounds in adulthood. A large amount of cellular replication may increase the risk of can...
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A trivalent HSV2 vaccine effectively protects experimental animals
A trivalent HSV2 vaccine effectively protects experimental animalsThe virus HSV2 affects about a half-billion people worldwide. It is imperative to develop an effective vaccine to stop this global pandemic. A recent clinical trial conducted by University of Pennsylvania researchers sho...
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New research reveals the structure of ACKR3
New research reveals the structure of ACKR3The atypical chemokine receptor 3 (ACKR3) is a membrane protein capable of binding chemokines CXCL11 and CXCL12. ACKR3 is upregulated in many cancer types, making it a potential drug target. Scientists have long sought t...
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Lipids play a role in cellular senescence
Lipids play a role in cellular senescenceIn a paper published in Molecular BioSystems, researchers report that lipids content in cells changes with age. The study, carried out by Darleny Lizardo, Yen-Lung Lin, Omer Gokcumen and Gunes Ekin Atilla-Gokcumen at Uni...
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Role of Ect2 in lung adenocarcinoma identified
Role of Ect2 in lung adenocarcinoma identifiedLung adenocarcinoma is a form of non-small cell lung cancer (NSCLC). NSCLC takes up about 85% of lung cancers, and about half of these are adenocarcinomas. Now Mayo Clinic researchers find a genetic promoter that driv...
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Protein klotho prevents kidney function decline
Protein klotho prevents kidney function declineKlotho is a transmembrane protein that is predominantly expressed in the kidney but also in multiple other tissues. This protein helps control insulin sensitivity and appears to have anti-aging properties. Previous studi...
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Fibrinogen drives repair response after acetaminophen-induced liver injury
Fibrinogen drives repair response after acetaminophen-induced liver injuryAcetaminophen is a common drug used for relieving pain and fever, and it is also used in combination with other active ingredients. A regular dosage is very safe, even for people with liver disease. However, an overdose ...
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Enzyme found in yeast may be a treatment option for ALL patients
Enzyme found in yeast may be a treatment option for ALL patientsAn enzyme found in baker's yeast has the ability to kill acute lymphoblastic leukemia (ALL) cells, according to a study published online in Scientific Reports. The study, directed by Gisele Monteiro from the University o...
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Study provides clues to the mechanism of AIDS-related dementia
Study provides clues to the mechanism of AIDS-related dementiaHIV infection can cause mental decline and worsening motor skills. These symptoms are somewhat common in HIV-infected people. Now a study led by Kevin Fox from Cardiff University and Alcino Silva from the University ...
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CPEB4 protein prevents fatty liver
CPEB4 protein prevents fatty liverA protein called CPEB4 can prevent fatty liver disease, according to a study published in Nature Cell Biology on 16 January 2017. Currently, non-alcoholic fatty liver disease (NFLD) affects 20-30% of people in Western...
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Small molecules that inhibit influenza virus may also inhibit Zika virus
Small molecules that inhibit influenza virus may also inhibit Zika virusIn 2012, Denis E. Kainova at the Institute for Molecular Medicine Finland found that three small molecules -- obatoclax, saliphenylhalamide, and gemcitabine -- are able to inhibit influenza virus infection. These molecul...
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A natural compound may be used for Parkinson's disease
A natural compound may be used for Parkinson's diseaseSqualamine is an aminosterol that is originally found in the tissues of the spiny dogfish shark. The compound can also be synthesized in the laboratory. Squalamine is known to have anti-microbial activity. Numerous studi...
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Smurf1 protein helps clear Mycobacterium tuberculosis
Smurf1 protein helps clear Mycobacterium tuberculosisTuberculosis (TB), a disease caused by the bacterium Mycobacterium tuberculosis (Mtb), is one of the top 10 causes of death worldwide. The World Health Organization says that 480,000 people developed multidrug-resistant ...
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Researchers identify a protein that reduces the effect of a common drug for AML
Researchers identify a protein that reduces the effect of a common drug for AMLAcute myeloid leukemia (AML) represents a group of cancers that affect the myeloid line of blood cells. As many as 350,000 people worldwide are diagnosed with AML each day. Left untreated, the disease usually gets worse ...
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Researchers find a novel protein that regulates telomere length
Researchers find a novel protein that regulates telomere lengthResearchers identified a protein that regulates telomere, the clock of a cell, a discovery that would have profound medical implications. Telomere is a distinctive structure of repetitive nucleotide sequences found at...
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A malaria drug triggers tumor cell apoptosis
A malaria drug triggers tumor cell apoptosisChloroquine is a drug that has long been used to treat and prevent malaria. This antimalarial agent sometimes is given off-label to treat other diseases such as arthritis, lupus, and rheumatoid arthritis. In addition, ac...
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Novel target for the intervention of HCMV infection
Novel target for the intervention of HCMV infectionA team headed by Nicholas Buchkovicha at Pennsylvania State University College of Medicine has developed a compound to combat human cytomegalovirus (HCMV), a species of the Cytomegalovirus genus of viruses. In the nor...
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Switching off RAD51 may enhance the effect of radiotherapy
Switching off RAD51 may enhance the effect of radiotherapyA team led by Dr Susan Short from University of Leeds has found that switching off a protein that helps repair DNA damage can sensitize glioblastoma cells to radiotherapy. The study results have been published in Stem Ce...
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Scientists identify genetic mutations associated with prognosis in Crohn's disease
Scientists identify genetic mutations associated with prognosis in Crohn's diseaseCrohn's disease is a disease with a complex cause and pathogenesis. It is not caused by one single gene but by multiple genes. So far, scientists have identified as many as 170 genetic mutations that increase the risk of...
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Dab2 protein is also involved in fat storage
Dab2 protein is also involved in fat storageIn a paper published online in Scientific Reports, researchers of University of Miami Miller School of Medicine report that a protein termed Disabled-2 (Dab2) is involved in fat storage. Previous studies have linked D...
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