Study shows how an antibody neutralizes Zika virus
Study shows how an antibody neutralizes Zika virusA study led by scientists from Duke-NUS Medical School and the University of North Carolina has shown how an antibody binds to the Zika virus (ZIKV) and prevents it from infecting a cell. The results, which have been pub...
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Stabilization of TIP60 is a new way to treat certain cancer types
Stabilization of TIP60 is a new way to treat certain cancer typesScientists from the National University of Singapore have identified a novel mechanism that drives the spread of breast cancer, a discovery that will lead to novel treatment strategies for certain types of breast cancer....
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Exosomes released by the pancreas can trigger autoimmne responses in diabetes
Exosomes released by the pancreas can trigger autoimmne responses in diabetesType-1 diabetes (T1D) is a type of organ-specific autoimmune disease. It occurs when the body's immune system attacks the insulin-producing cells in the pancreas. Although it is known that the immune cells target intrace...
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Detection of p15 expression helps to distinguish between nevus and melanoma
Detection of p15 expression helps to distinguish between nevus and melanomaMelanoma is a type of skin cancer due to uncontrolled growth of pigment cells. This out-of-control cell replication is caused by gene mutations. But some nevi with the same mutations have growth arrest. In some cases, ne...
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New research will guide the design of MERS vaccines
New research will guide the design of MERS vaccinesThe Middle East respiratory syndrome (MERS) is a viral respiratory disease caused by a virus called MERS‐CoV. The disease was first identified in Saudi Arabia in 2012, and the mortality rates reached up to 36%. Current...
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Researchers unravel the effects of titin mutations in healthy people
Researchers unravel the effects of titin mutations in healthy peopleScientists have known for some time that genetic mutations in a protein called titin can cause dilated cardiomyopathy (DCM), a common disease of the heart muscle. But many people that carry titin mutations exhibit no sig...
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ALK1 protein mediates the transport of LDL into tissue
ALK1 protein mediates the transport of LDL into tissueScientists from Yale University School of Medicine have found that a protein called activin-like kinase 1 (ALK1) mediates LDL uptake into endothelial cells. The findings, published in the journal Nature Communications, c...
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NIH scientists create innovative approach to treat allergic diseases
NIH scientists create innovative approach to treat allergic diseasesA new study published in Proceedings of the National Academy of Sciences shows that using the exon skipping technique to eliminate the IgE receptor on mast cells is a potential way to treat allergic diseases. The study, ...
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Chinese scientists identify a genetic link to a rare, aggressive cancer
Chinese scientists identify a genetic link to a rare, aggressive cancerA research team, headed by Prof Jin-Xin Bei at Sun Yat-Sen University Cancer Center, China, has identified a genetic mutation that increases the risk of extranodal natural killer T-cell lymphoma (NKTCL), a rare, aggressi...
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Melanoma is very dependent on the CPEB4 protein
Melanoma is very dependent on the CPEB4 proteinMelanoma is a less common but most dangerous form of skin cancer -- it is the leading cause of death from skin cancer. The cancer develops in pigment cells called melanocytes. The mechanism of melanoma is complex because...
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Smoking lowers the efficacy of kidney disease drugs
Smoking lowers the efficacy of kidney disease drugsAccording to a new study, smoking may affect the efficacy of drugs for chronic kidney disease (CKD). The study was carried out by scientists from Tufts Medical Center. CKD is a medical condition characterized by a gra...
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Scientists identify a similar pattern of epigenetic modification in autism patients
Scientists identify a similar pattern of epigenetic modification in autism patientsScientists from the University of California have identified a same pattern of histone acetylation in the brain of people with different forms of autism spectrum disorder (ASD). The findings, reported in the journal Cell...
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High RSK2 expression correlates with glioblastoma invasiveness
High RSK2 expression correlates with glioblastoma invasivenessGlioblastoma (GBM), the most common and most malignant brain tumor, can affect people of all ages. The disease is quite difficult to treat because the tumors contain many different types of cells. Chemotherapy and r...
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Scientists pave the way toward new treatments for Alzheimer's disease
Scientists pave the way toward new treatments for Alzheimer's diseaseA team of researchers from Tel Aviv University, headed by Dr. David Gurwitz, has demonstrated that the expression of a gene called RGS2 is decreased in Alzheimer's disease (AD), the most common form of dementia among the...
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BRD4 protein is critical to breast cancer metastasis
BRD4 protein is critical to breast cancer metastasisBRD4, a member of the BET family of proteins, is needed for the metastasis of breast cancer. Moreover, inhibiting the protein blocks the dissemination capabilities of triple-negative breast cancer cells. Scientists from ...
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Mutation in Tmem135 protein may lead to age-dependent diseases
Mutation in Tmem135 protein may lead to age-dependent diseasesUnderstanding the aging process would probably help you understand the pathogenesis of age-dependent diseases. But more research is needed to elucidate the aging process at the molecular level. Scientists at the Universi...
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Scientists identify a signaling pathway that controls blood sugar
Scientists identify a signaling pathway that controls blood sugarA new study appearing in the journal Developmental Cell shows that neurotrophins help control insulin secretion, a finding that would lead to a better understanding of type-2 diabetes. Type-2 diabetes is the most comm...
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Mayo scientists find novel biomarker for brain inflammation
Mayo scientists find novel biomarker for brain inflammationA team of scientists led by Dr. Vanda Lennon from Mayo Clinic has identified a biomarker in the blood and spinal fluid of people who have autoimmune meningoencephalomyelitis. The biomarker, which is an antibody, would ai...
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Blocking exosome release might be an approach to treat pancreatic cancer
Blocking exosome release might be an approach to treat pancreatic cancerA team of researchers from the University of Notre Dame and the Harper Cancer Research Institute has found a new approach to treat pancreatic cancer, one of the most common causes of cancer-related death. According to...
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Scientists design compounds that target a recently discovered enzyme in bacteria
Scientists design compounds that target a recently discovered enzyme in bacteriaAccording to a study appearing in the journal Nature Chemical Biology, inhibiting a critical enzyme in bacteria could be a way to combat certain antibiotic-resistant bacteria, such as the bacterium responsible for tuberc...
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Existing drugs suppress a pathway associated with inflammatory diseases
Existing drugs suppress a pathway associated with inflammatory diseasesA team of researchers led by Timothy M. Palmer from the University of Bradford has identified a novel pathway that seems to be associated with inflammatory disorders, and the pathway can be manipulated by two existing dr...
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Protein TRAP1 may contribute to prostate cancer
Protein TRAP1 may contribute to prostate cancerA new study appearing in the Journal of Biological Chemistry shows how the TRAP1 protein drives prostate cancer. The study, conducted by The Wistar Institute researchers, would provide a novel treatment strategy for pros...
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Mutations in autism gene disrupt synaptic development
Mutations in autism gene disrupt synaptic developmentAutism spectrum disorder (ASD) is a group of neurological and developmental disorders that can cause significant social communication and behavioral challenges. ASD is estimated to affect one in 68 people and it is aroun...
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Antibody specific to sclerostin reduces bone loss caused by radiotherapy
Antibody specific to sclerostin reduces bone loss caused by radiotherapyRadiotherapy is a treatment that involves the use of high-energy radiation. Radiotherapy is one of the most common treatments for cancer. At least one in two people with cancer would benefit from radiotherapy. High-energ...
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Newly identified biomarkers for progression of Huntington's disease
Newly identified biomarkers for progression of Huntington's diseaseA research team led by Daria Mochly-Rosen from Stanford University School of Medicine has found biomarkers that can help track the progression of Huntington's disease (HD), an incurable, hereditary brain disorder. HD ...
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New study sheds light on the genetic mechanism of X-linked Retinoschisis
New study sheds light on the genetic mechanism of X-linked RetinoschisisX-linked Retinoschisis (XLRS) is an inherited eye disorder characterized by reduced visual acuity due to juvenile macular degeneration. It is caused by over 230 mutations in the RS1 gene, which encodes the protein retino...
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Oxford scientists find a way to optimize the treatment of autoimmune disorders
Oxford scientists find a way to optimize the treatment of autoimmune disordersPublished in the journal Science Translational Medicine, a study shows that there might be a way to decrease the adverse effects of treatment for autoimmune disorders. An autoimmune disorder is a condition that occurs...
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Malaria research reveals two genetic markers for drug resistance
Malaria research reveals two genetic markers for drug resistanceAccording to an article published in Lancet Infectious Diseases, a research team led by researchers from the Wellcome Trust Sanger Institute has identified two genetic markers associated with resistance to an important a...
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Scientists find a way to develop better treatments for Visceral leishmaniasis
Scientists find a way to develop better treatments for Visceral leishmaniasisVisceral leishmaniasis (VL), also known as kala-azar and black fever, is a chronic and fatal parasitic disease that affects the liver, spleen, lymph nodes and many other important organs and tissues. It is caused by a sp...
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Parkinson's disease: single mutation confers great risk
Parkinson's disease: single mutation confers great riskAccording to a study appearing in the Brain journal, an international research team led by Dr. Wolfdieter Springer at Mayo Clinic has found that a single mutation in the PINK1 gene is able to increase the risk of Parkins...
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Blocking fat synthesis in certain immune cells may prevent chronic inflammation in diabetes
Blocking fat synthesis in certain immune cells may prevent chronic inflammation in diabetesDiabetes, also known as diabetes mellitus, is a group of diseases in which a person has high blood sugar. Over time, it can cause a range of complications, such as heart disease, nerve damage, eye problems, and kidney di...
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New research shows cellular senescence also has harmful effects
New research shows cellular senescence also has harmful effectsAccording to a study recently published in the Journal of Cell Biology, the HMGB2 protein is involved in the expression of cytokines and chemokines during cellular senescence. The study, led by Professor Rugang Zhang at ...
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BET inhibitor significantly reduces ovarian cancer drug resistance
BET inhibitor significantly reduces ovarian cancer drug resistanceOvarian cancer is one of the most common cancers among women. It causes more deaths than any other cancer of the female reproductive system. In 2012, about 239,000 women worldwide were diagnosed with ovarian cancer, and ...
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SIRT2 may be a promising target for a deadly form of breast cancer
SIRT2 may be a promising target for a deadly form of breast cancerIn the past decade, much progress has been made in the treatment of breast cancer. For most forms of breast cancer, tailored targeted therapies can improve patients' survival. However, a more aggressive form of breast ca...
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TPP1 mutation leads to dyskeratosis congenita
TPP1 mutation leads to dyskeratosis congenitaA study from the University of Michigan shows how a mutation in the telomere protein TPP1 causes dyskeratosis congenita (DKC), a rare, inherited bone marrow disorder. The finding provides a new target for the future trea...
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Researchers identify two genes that appear to be linked to atherosclerosis
Researchers identify two genes that appear to be linked to atherosclerosisAccording to a study recently published in Nature Communications, activation of two genes -- PARP9 and PARP14 -- may be associated with atherosclerosis, a chronic inflammatory disease that affects the large arteries. The...
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New study confirms link between mtDNA variation and ASD
New study confirms link between mtDNA variation and ASDAutism spectrum disorder (ASD) refers to a group of neurodevelopmental disorders that usually begin early in childhood and last a lifetime. Patients with ASD often have problems with social interaction, communication and...
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CUMC researchers identify therapeutic target for nonalcoholic steatohepatitis
CUMC researchers identify therapeutic target for nonalcoholic steatohepatitisPublished online in the journal Cell Metabolism, a new study reveals that blocking the TAZ protein can stop and even reverse fibrosis in the liver of mice. Nonalcoholic fatty liver disease (NAFLD) is a group of diseas...
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Hsp60 protein contributes to tissue regeneration
Hsp60 protein contributes to tissue regeneration An article published in npj Regenerative Medicine shows that the heat shock protein 60 (Hsp60) plays a critical role in tissue regeneration and wound healing. The study, led by scientists at the National Institutes of He...
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CYFIP2 gene is related to binge eating
CYFIP2 gene is related to binge eatingAccording to a study published in Biological Psychiatry, a gene called CYFIP2 (cytoplasmic FMR1-interacting protein 2) is linked to binge eating, which is a central feature of eating disorders such as bulimia nervosa and...
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Niemann-Pick disease type C1 may be treated with gene therapy
Niemann-Pick disease type C1 may be treated with gene therapyNiemann-Pick disease is a group of inherited, fatal metabolic disorders that affect the central nervous system. It is caused by a mutation in genes that regulate lipid metabolism. Patients with the disorder have an abnor...
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Scientists find a new way to deliver dengue vaccines
Scientists find a new way to deliver dengue vaccinesDengue virus (DENV), which belongs to the family Flaviviridae, is the cause of dengue fever and dengue hemorrhagic fever. In fact, this mosquito-borne virus infects over 350 million people in more than 120 countries annu...
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Zika virus may also damage adult brain, research finds
Zika virus may also damage adult brain, research findsA study, led by researchers from The Rockefeller University and the La Jolla Institute for Allergy and Immunology, shows that Zika virus may cause damage to the brain of adults. The findings have been published online in...
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Inhibiting CPEB1 may prevent CMV infection
Inhibiting CPEB1 may prevent CMV infectionA study from University of California San Diego School of Medicine shows that cytomegalovirus (CMV) infection is dependent on a human protein termed CPEB1. Described in the journal Nature Structural and Molecular Biology...
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Blood biomarkers of early pancreatic cancer identified
Blood biomarkers of early pancreatic cancer identifiedScientists in Japan have found plasma biomarkers of pancreatic cancer, a discovery that could contribute to the early diagnosis of this fatal cancer. Pancreatic cancer, also known as the "king of cancer", is a high...
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Novel way to decrease tau accumulation in Alzheimer's disease
Novel way to decrease tau accumulation in Alzheimer's diseaseA collaborative research team has found a way to decrease tau accumulation and halt the development of Alzheimer's disease (AD). Their findings, published Oct. 19 in the journal Neuron, shows that reduction of an enzyme ...
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Scientists link ATAD3A mutations to neurological syndromes
Scientists link ATAD3A mutations to neurological syndromesAn international research team has identified that a gene called ATAD3A could be associated with certain neurological syndromes. The study could not only extend the understanding of the pathogenesis of these disorders bu...
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New research could facilitate development of therapies against ALS
New research could facilitate development of therapies against ALSAmyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that selectively affects motor neurons, a type of nerve cells that enable us to move our bodies. Over 90% of all cases of ALS have no known c...
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STEP protein contributes to schizophrenia pathophysiology
STEP protein contributes to schizophrenia pathophysiologyA study, led by scientists at Yale University, has demonstrated that a protein associated with cognitive decline in Alzheimer's disease (AD) is also involved in schizophrenia. In the paper, which has been published Oct. ...
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NF1 gene is responsible for some cases of autism
NF1 gene is responsible for some cases of autismA gene that causes neurofibromatosis type 1 (NF1) may also contribute to autism, according to a new study carried out by researchers at Washington University School of Medicine. NF1 is a genetic disorder that usually ...
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